Reporter Discrepancies Among Parents, Adolescents, and Peers: Adolescent Attachment and Informant Depressive Symptoms as Explanatory Factors

This is the peer reviewed version of the following article: Ehrlich, K.B., Cassidy, J. and Dykas, M.J. (2011), Reporter Discrepancies Among Parents, Adolescents, and Peers: Adolescent Attachment and Informant Depressive Symptoms as Explanatory Factors. Child Development, 82: 999-1012., which has been published in final form at https://doi.org/10.1111/j.1467-8624.2010.01530.x . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.The issue of informant discrepancies about child and adolescent functioning is an important concern for clinicians, developmental psychologists, and others who must consider ways of handling discrepant reports of information, but reasons for discrepancies in reports have been poorly understood. Adolescent attachment and informant depressive symptoms were examined as 2 explanations for absolute and directional discrepancies about adolescent symptoms, relationships, and social behavior in a sample of 189 eleventh-grade students (mean age = 16.5 years). Adolescent attachment predicted absolute discrepancies, with greater attachment coherence associated with fewer discrepancies in reports of adolescent depressive symptoms, parent–adolescent conflict, and adolescent externalizing behavior. Parents’ but not adolescents’ depressive symptoms sometimes predicted absolute discrepancies. Mothers’ depressive symptoms and adolescent attachment predicted the direction of discrepancies for mother–peer reports only.https://doi.org/10.1111/j.1467-8624.2010.01530.

Tipping Points in Adolescent Adjustment: Predicting Social Functioning from Adolescents’ Conflict with Parents and Friends

©American Psychological Association, 2012. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. The final article is available, upon publication, at: https://doi.org/10.1037/a0029868Despite widespread interest in examining the role of conflict for adolescent development, researchers only rarely have examined adolescents' experiences of conflict across relationships. The present study examined how adolescents' experiences of conflict with parents and friends were linked to their social functioning. Adolescents (n = 189) and their mothers and fathers participated in semistructured discussions about areas of parent-adolescent conflict in the laboratory. In addition, adolescents reported about conflict in their best friendships, and peers reported about adolescents' social acceptance and behavior in social settings. Parent–adolescent conflict was associated with peer-reported aggression and delinquency, and friendship conflict was associated with delinquency and prosocial behavior. In addition, significant Parent–Adolescent Conflict × Friend–Adolescent Conflict interactions revealed that parent–adolescent conflict was associated with poor social functioning only when conflict with best friends was also high. The findings suggest that consideration of conflict across relationships may yield insight into the specific contexts in which conflict is associated with negative outcomes for adolescents. (PsycInfo Database Record (c) 2020 APA, all rights reserved)https://doi.org/10.1037/a002986

Quality of Relationships with Parents and Friends in Adolescence Predicts Metabolic Risk in Young Adulthood

Objective: This study was designed to examine whether family and peer relationships in adolescence predict the emergence of metabolic risk factors in young adulthood. Method: Participants from a large, nationally representative cohort study (N = 11,617 for these analyses) reported on their relationship experiences with parents and close friends during adolescence. Fourteen years later, interviewers collected blood samples, as well as anthropometric and blood pressure measurements. Blood samples were analyzed for HbA1c. Results: Ordered logistic regressions revealed that for females, supportive parent–child relationships and close male friendships in adolescence were associated with reduced odds of having elevated metabolic risk markers in young adulthood. These effects remained significant even after controlling for baseline measures of body mass index (BMI) and health and demographic covariates. The protective effects of close relationships were not significant for males, however. Exploratory analyses with 2-parent families revealed that supportive father–child relationships were especially protective for females. Conclusions: These findings suggest that, for females, close and supportive relationships with parents and male friends in adolescence may reduce the risk of metabolic dysregulation in adulthood

Parental Knowledge of Adolescent Activities: Links With Parental Attachment Style and Adolescent Substance Use

©American Psychological Association, 2015. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. The final article is available, upon publication, at: https://doi.org/10.1037/fam0000070Parents’ knowledge of their adolescents’ whereabouts and activities is a robust predictor of adolescent risk behavior, including the use of drugs and alcohol. Surprisingly few studies have attempted to identify parental characteristics that are associated with the degree of parental knowledge. The present study is the first to examine how parental attachment style relates to mother, father, and adolescent reports of parental knowledge. Further, we used structural equation modeling to test the associations among parents’ attachment styles, reports of parental knowledge, and adolescents’ alcohol and marijuana use. Participants included 203 adolescents (M age = 14.02, SD = .91) living in 2-parent households and their parent(s). As predicted, mothers’ and fathers’ insecure attachment styles were negatively associated with self-reported and adolescent-reported parental knowledge, and all 3 reports of parental knowledge were negatively related to adolescent substance use. Mothers’ and fathers’ attachment styles were unrelated to adolescent substance use. However, evidence emerged for indirect effects of parental attachment style on adolescent substance use through reports of parental knowledge. Implications for prevention efforts and the importance of multiple reporters within the family are discussed. (PsycInfo Database Record (c) 2020 APA, all rights reserved)https://doi.org/10.1037/a002986

Do Adolescents and Parents Reconstruct Memories About Their Conflict as a Function of Adolescent Attachment?

This is the peer reviewed version of the following article: Dykas, M.J., Woodhouse, S.S., Ehrlich, K.B. and Cassidy, J. (2010), Do Adolescents and Parents Reconstruct Memories About Their Conflict as a Function of Adolescent Attachment?. Child Development, 81: 1445-1459., which has been published in final form at https://doi.org/10.1111/j.1467-8624.2010.01484.x . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.This study examined whether 17-year-old adolescents (n = 189) and their parents reconstructed their memory for an adolescent–parent laboratory conflict over a 6-week period as a function of adolescent attachment organization. It also compared participants’ perceptions of conflict over time to observational ratings of the conflict to further characterize the nature of the attachment-related memory biases that emerged. Secure adolescents reconstructed interactions with each parent more favorably over time, whereas insecure adolescents showed less favorable reconstructive memory. Likewise, mothers of secure girls reconstructed conflicts more favorably over time, whereas mothers of insecure boys showed less favorable reconstructive memory. Participant ratings were associated with observational ratings in theoretically consistent ways. Contrary to expectations, fathers showed no attachment-related memory biases.https://doi.org/10.1111/j.1467-8624.2010.01484.

Adolescent Friendships in the Context of Dual Risk: The Roles of Low Adolescent Distress Tolerance and Harsh Parental Response to Adolescent Distress

©American Psychological Association, 2013. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. The final article is available, upon publication, at: https://doi.org/10.1037/a0032587Given extensive evidence about the importance of relationships with friends during development, a large body of research has examined the correlates of these significant social experiences. Most of this research, however, has examined either individual characteristics (e.g., behavior, personality) or contextual factors (e.g., family), and most of the work has studied relationships during childhood. The present study extended previous research by examining how both an individual factor (adolescent distress tolerance) and a contextual factor (parental response to adolescent distress) are linked to adolescents’ friendships. Adolescents (N = 161) completed two behavioral measures of distress tolerance, and parents reported about their responses to adolescent distress. Although distress tolerance and parental responses to distress were not directly associated with adolescents’ positive or negative friendship experiences, for adolescents with low distress tolerance, harsh parental responses were negatively associated with adolescents’ positive friendship quality. Further, for adolescents whose parents used harsh responses to distress, distress tolerance was negatively associated with adolescents’ positive friendship quality. Results highlight the importance of studying both individual and familial factors related to adolescents’ social functioning. (APA PsycInfo Database Record (c) 2016 APA, all rights reserved)https://doi.org/10.1037/a003258

Maternal Attachment Style and Responses to Adolescents’ Negative Emotions: The Mediating Role of Maternal Emotion Regulation

This is an Accepted Manuscript of an article published by Taylor & Francis in Parenting: Science and Practice on November 11, 2014, available online: https://doi.org/10.1080/15295192.2014.972760 .Objective. Previous research has examined the developmental consequences, particularly in early childhood, of parents’ supportive and unsupportive responses to children’s negative emotions. Much less is known about factors that explain why parents respond in ways that may support or undermine their children’s emotions, and even less is known about how these parenting processes unfold with adolescents. In the present study, researchers examined the associations between mothers’ attachment styles and their distress, harsh, and supportive responses to their adolescents’ negative emotions two years later and whether these links were mediated by maternal emotion regulation difficulties. Design. Mothers in a longitudinal study (n = 230) reported on their attachment style, difficulties regulating their emotions, and their hypothetical responses to their adolescents’ negative emotions, respectively, at consecutive laboratory visits one year apart. Results. Mothers who reported greater attachment-related avoidance and anxiety reported having greater difficulties with emotion regulation one year later. Emotion dysregulation, in turn, predicted more distressed, harsher, and less supportive maternal responses to adolescents’ negative emotions the following year. In addition, greater avoidance directly predicted harsher maternal responses two years later. Conclusions. These findings extend previous research by identifying maternal attachment style as a predictor of responses to adolescent distress and by documenting the underlying role of emotion dysregulation in the link between adult attachment style and parenting.https://doi.org/10.1080/15295192.2014.97276

Stability of Attachment Style in Adolescence: An Empirical Test of Alternative Developmental Processes

This is the peer reviewed version of the following article: Jones, J.D., Fraley, R.C., Ehrlich, K.B., Stern, J.A., Lejuez, C.W., Shaver, P.R. and Cassidy, J. (2018), Stability of Attachment Style in Adolescence: An Empirical Test of Alternative Developmental Processes. Child Dev, 89: 871-880., which has been published in final form at https://doi.org/10.1111/cdev.12775 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.Few studies have examined stability and change in attachment during adolescence. This 5-year longitudinal study (a) examined whether prototype or revisionist developmental dynamics better characterized patterns of stability and change in adolescent attachment (at T1, N = 176; M age = 14.0 years, SD = 0.9), (b) tested potential moderators of prototype-like attachment stability, and (c) compared attachment stability in adolescence to stability in adulthood. The results supported the prototype model, which assumes that there is a stable, enduring factor underlying stability and change in attachment. Exploratory moderation analyses revealed that family conflict, parental separation or divorce, minority status, and male sex might undermine the prototype-like stability of adolescent attachment. Stability of attachment was lower in adolescence relative to adulthood.https://doi.org/10.1111/cdev.1277

Dynamics of Dynamin during Clathrin Mediated Endocytosis in PC12 Cells

Members of the dynamin super-family of GTPases are involved in disparate cellular pathways. Dynamin1 and dynamin2 have been implicated in clathrin-mediated endocytosis. While some models suggest that dynamin functions specifically at the point of vesicle fission, evidence also exists for a role prior to fission during vesicle formation and it is unknown if there is a role for dynamin after vesicle fission. Although dynamin2 is ubiquitously expressed, dynamin1 is restricted to the nervous system. These two structurally similar endocytic accessory proteins have not been studied in cells that endogenously express both.The present study quantitatively assesses the dynamics of dynamin1 and dynamin2 during clathrin-mediated endocytosis in PC12 cells, which endogenously express both proteins. Both dynamin isoforms co-localized with clathrin and showed sharp increases in fluorescence intensity immediately prior to internalization of the nascent clathrin-coated vesicle. The fluorescence intensity of both proteins then decreased with two time constants. The slower time constant closely matched the time constant for the decrease of clathrin intensity and likely represents vesicle movement away from the membrane. The faster rate may reflect release of dynamin at the neck of nascent vesicle following GTP hydrolysis.This study analyses the role of dynamin in clathrin-mediated endocytosis in a model for cellular neuroscience and these results may provide direct evidence for the existence of two populations of dynamin associated with nascent clathrin-coated vesicles

Meta-Analysis of the Alzheimer\u27s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.

We present a consensus atlas of the human brain transcriptome in Alzheimer\u27s disease (AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples. We discover 30 brain coexpression modules from seven regions as the major source of AD transcriptional perturbations. We next examine overlap with 251 brain differentially expressed gene sets from mouse models of AD and other neurodegenerative disorders. Human-mouse overlaps highlight responses to amyloid versus tau pathology and reveal age- and sex-dependent expression signatures for disease progression. Human coexpression modules enriched for neuronal and/or microglial genes broadly overlap with mouse models of AD, Huntington\u27s disease, amyotrophic lateral sclerosis, and aging. Other human coexpression modules, including those implicated in proteostasis, are not activated in AD models but rather following other, unexpected genetic manipulations. Our results comprise a cross-species resource, highlighting transcriptional networks altered by human brain pathophysiology and identifying correspondences with mouse models for AD preclinical studies