Chitosan and Hydroxypropyl Methylcellulose as release retardant for Aceclofenac

Plenty of natural polymers has been found effective to modulate the drug release. Numerous natural polymers either alone or in combination with other polymers were found effective in controlling the drug release. In the current study attempts were made to combine chitosan (degree of deacetylation 88.42 %, Molecular weight 50,000 Da, and viscosity 93 CPS) and HPMC K 15M to retard the release of aceclofenac in tablet formulation. The tablets were prepared by wet granulation method and evaluated for pre and post- compression parameters. All the pre-compression parameters were found within the limit.  The mechanical strength was determined in terms of hardness and friability values these were found in the range of 4.16-5.22 kg/cm2 and 0.1-0.75% respectively. The drug content was found in the range of 97.51 – 99.66 %.  Weight variation test complied the official limit as per Indian Pharmacopoeia.  With increasing the concentration of both the polymers the swelling index was increased and drug release decrease. Highest concentration of both the polymers was found to retard the drug release up to 8 h. &nbsp