Moment inequalities and their application

This paper provides conditions under which the inequality constraints generated by either single agent optimizing behavior, or by the Nash equilibria of multiple agent problems, can be used as a basis for estimation and inference. We also add to the econometric literature on inference in models defined by inequality constraints by providing a new specification test and methods of inference for the boundaries of the model's identified set. Two applications illustrate how the use of inequality constraints can simplify the problem of obtaining estimators from complex behavioral models of substantial applied interest.

Physician incentives introduced by the new Accountable Care Organizations could reduce costs of care by 5 percent

The U.S. spends more on healthcare as a percentage of GDP and on a per capita basis, than any other country in the world, something that aspects of 2010’s Affordable Care Act aim to alleviate. Kate Ho and Ariel Pakes take a close look at the likely effects of Accountable Care Organizations: groups of providers whose payment arrangements give physicians incentives to control costs. They find that through capitation (flat, fixed payments) and the sharing of savings, these new organizations could reduce healthcare costs by between 4.5 and 5 percent without corresponding quality reductions

Is health insurance competition good for consumers?

Less insurer competition can lower hospital prices, but savings may not reach consumers, write Kate Ho and Robin S. Le

Practicality in POCUS: Benefits of Ultrasound Training in Medical Education

As point-of-care ultrasound (POCUS) becomes an integral component of healthcare, both undergraduate and graduate medical POCUS education is urgently necessary in curricula. Despite the apparent need of POCUS curricula, there remains a lingering question: Are there evidence-based benefits to POCUS training in undergraduate and/or graduate medical education settings? This systematic review utilized PubMed, Google Scholar, and Scopus to identify articles of interest that met the inclusion criteria and relevance to undergraduate and/or graduate medical education. Qualitative evaluation of research was conducted to identify common themes for benefits of POCUS and the requirements or characteristics for effective POCUS educational curricula. Results for undergraduate medical education were separated into pre-clinical and clinical education. In pre-clinical POCUS education, POCUS education improves anatomy education and physical examination skills for sonographic assessment of abdominal, reproductive, cardiovascular, and renal structures. Further enhancement can be achieved via simulation devices that are generalized ultrasound simulation mannequins, one defined body region such as the abdomen, or local regions of interest such as the femoral triangle. In clinical undergraduate POCUS education, benefits involved greater performance on knowledge tests and general ultrasound competency in emergency medicine, surgical, family medicine, and physical medicine and rehabilitation clerkships. These studies also found improved comprehension of specific POCUS examinations such as those for ultrasound-guided injections, FAST, eFAST, and RUSH. Further integration of POCUS education into graduate medical education was found to successfully improve ultrasound knowledge and competency in both academic and military internal medicine residencies. One limitation of this study is that this article is a review resulting in no specific intervention being introduced. The resultant hypothesis of this systematic review cannot be tested; rather evidence-based recommendations are restricted to the currently available literature within the searched databases. From this review, it was found that the inclusion of a properly integrated POCUS curriculum can result in greater confidence in ultrasound use, increased knowledge of anatomy and basic sciences for various organ systems, improved ultrasound knowledge and performance in clinical clerkships, and offers improved confidence and knowledge in ultrasound during residency

Post Project Appraisal for Stoney Creek Off-channel Habitat Pond: Hydrological Suitability for Juvenile Salmonids

Habitat restoration is an important process in protecting the iconic salmon in British Columbia. Specific criteria must be met in order to provide a successful salmon habitat. Water quality within the off-channel pond at Stoney Creek was analyzed with data collected from six essential parameters: turbidity, velocity, depth, as well as copper, nitrogen and iron. These were tested over two days under different weather conditions. Turbidity, velocity, iron and nitrates presented preferable conditions while depth could potentially be improved for the salmon’s wellbeing. Copper testing was determined to be inconclusive. We conclude that the Stoney Creek off-channel pond is an appropriate water habitat for juvenile salmonids to rest and develop. Possible future management strategies include increasing the overall depth, continued monitoring by the Stoney Creek Environment Committee, future copper testing with more sensitive equipment after a first flush event, and an increase in public outreach and education

Outcomes of implementation of team of ‘Medicaid Application Counselors’ at UM Student-Run Free Clinic to increase health insurance enrollment

Medical Schoolhttps://deepblue.lib.umich.edu/bitstream/2027.42/149395/1/HillaryPaulsen_1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149395/2/HillaryPaulsen_2.ppt

The REFOLD database: a tool for the optimization of protein expression and refolding

A large proportion of proteins expressed in Escherichia coli form inclusion bodies and thus require renaturation to attain a functional conformation for analysis. In this process, identifying and optimizing the refolding conditions and methodology is often rate limiting. In order to address this problem, we have developed REFOLD, a web-accessible relational database containing the published methods employed in the refolding of recombinant proteins. Currently, REFOLD contains >300 entries, which are heavily annotated such that the database can be searched via multiple parameters. We anticipate that REFOLD will continue to grow and eventually become a powerful tool for the optimization of protein renaturation. REFOLD is freely available at

Millimeter Observations of the Type II SN2023ixf: Constraints on the Proximate Circumstellar Medium

We present 1.3 mm (230 GHz) observations of the recent and nearby Type II supernova, SN2023ixf, obtained with the Submillimeter Array (SMA) at 2.6-18.6 days after explosion. The observations were obtained as part the SMA Large Program POETS (Pursuit of Extragalactic Transients with the SMA). We do not detect any emission at the location of SN2023ixf, with the deepest limits of $L_\nu(230\,{\rm GHz})\lesssim 8.6\times 10^{25}$ erg s$^{-1}$ Hz$^{-1}$ at 2.7 and 7.7 days, and $L_\nu(230\,{\rm GHz})\lesssim 3.4\times 10^{25}$ erg s$^{-1}$ Hz$^{-1}$ at 18.6 days. These limits are about a factor of 2 times dimmer than the mm emission from SN2011dh (IIb), about an order of magnitude dimmer compared to SN1993J (IIb) and SN2018ivc (IIL), and about 30 times dimmer than the most luminous non-relativistic SNe in the mm-band (Type IIb/Ib/Ic). Using these limits in the context of analytical models that include synchrotron self-absorption and free-free absorption we place constraints on the proximate circumstellar medium around the progenitor star, to a scale of $\sim 2\times 10^{15}$ cm, excluding the range $\dot{M}\sim {\rm few}\times 10^{-6}-10^{-2}$ M$_\odot$ yr$^{-1}$ (for a wind velocity, $v_w=115$ km s$^{-1}$, and ejecta velocity, $v_{\rm eje}\sim (1-2)\times 10^4$ km s$^{-1}$). These results are consistent with an inference of the mass loss rate based on optical spectroscopy ($\sim 2\times 10^{-2}$ M$_\odot$ yr$^{-1}$ for $v_w=115$ km s$^{-1}$), but are in tension with the inference from hard X-rays ($\sim 7\times 10^{-4}$ M$_\odot$ yr$^{-1}$ for $v_w=115$ km s$^{-1}$). This tension may be alleviated by a non-homogeneous and confined CSM, consistent with results from high-resolution optical spectroscopy.Comment: Submitte

Lymphatic blood filling in CLEC-2-deficient mouse models

C-type lectin-like receptor 2 (CLEC-2) is considered as a potential drug target in settings of wound healing, inflammation, and infection. A potential barrier to this is evidence that CLEC-2 and its ligand podoplanin play a critical role in preventing lymphatic vessel blood filling in mice throughout life. In this study, this aspect of CLEC-2/podoplanin function is investigated in more detail using new and established mouse models of CLEC-2 and podoplanin deficiency, and models of acute and chronic vascular remodeling. We report that CLEC-2 expression on platelets is not required to maintain a barrier between the blood and lymphatic systems in unchallenged mice, post-development. However, under certain conditions of chronic vascular remodeling, such as during tumorigenesis, deficiency in CLEC-2 can lead to lymphatic vessel blood filling. These data provide a new understanding of the function of CLEC-2 in adult mice and confirm the essential nature of CLEC-2-driven platelet activation in vascular developmental programs. This work expands our understanding of how lymphatic blood filling is prevented by CLEC-2-dependent platelet function and provides a context for the development of safe targeting strategies for CLEC-2 and podoplanin