Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts

The plant phytoalexin resveratrol was previously demonstrated to inhibit the differentiation and bone resorbing activity of osteoclasts, to promote the formation of osteoblasts from mesenchymal precursors in cultures, and inhibit myeloma cell proliferation, when used at high concentrations. In the current study, we screened five structurally modified resveratrol analogues for their ability to modify the differentiation of osteoclasts and osteoblasts and proliferation of myeloma cells. Compared to resveratrol, analogues showed an up to 5,000-fold increased potency to inhibit osteoclast differentiation. To a lesser extent, resveratrol analogues also promoted osteoblast maturation. However, they did not antagonize the proliferation of myeloma cells. The potency of the best-performing candidate in vitro was tested in vivo in an ovariectomy-induced model of osteoporosis, but an effect on bone loss could not be detected. Based on their powerful antiresorptive activity in vitro, resveratrol analogues might be attractive modulators of bone remodeling. However, further studies are required to establish their efficacy in vivo

Urszula Eckert (1928–2019) – życie i działalność pedagogiczna i naukowa

Prof. Urszula Eckert była pedagogiem specjalnym zaangażowanym w rehabilitację i edukację dzieci i młodzieży z wadą słuchu. Życie zawodowe związała z Akademią Pedagogiki Specjalnej w Warszawie, gdzie zajmowała się kształceniem pracowników naukowych i studentów, przyszłych nauczycieli i wychowawców uczniów z zaburzeniami słuchu. Jej prace naukowe koncentrowały się wokół wczesnej diagnozy i rewalidacji dzieci z uszkodzonym słuchem, w tym szczególnie korygowania i usprawniania słuchu i mowy

Urszula Eckert (1928–2019) – Her life and pedagogical and academic work

Prof. Urszula Eckert was a special educator committed to rehabilitation and education for children and adolescents with hearing impairments. She dedicated her professional life to The Maria Grzegorzewska University in Warsaw, where she provided training for research workers and students – future teachers of students with hearing impairments. Her scientific work focused on the early assessment and rehabilitation of children with hearing impairments, including specifically correcting and improving hearing and speech