Wharton’s Jelly Derived Mesenchymal Stem Cells: Future of Regenerative Medicine? Recent Findings and Clinical Significance

Around 5 million annual births in EU and 131 million worldwide give a unique opportunity to collect lifesaving Wharton’s jelly derived mesenchymal stem cells (WJ-MSC). Evidences that these cells possess therapeutic properties are constantly accumulating. Collection of WJ-MSC is done at the time of delivery and it is easy and devoid of side effects associated with collection of adult stem cells from bone marrow or adipose tissue. Likewise, their rate of proliferation, immune privileged status, lack of ethical concerns, nontumorigenic properties make them ideal for both autologous and allogeneic use in regenerative medicine applications. This review provides an outline of the recent findings related to WJ-MSC therapeutic effects and possible advantage they possess over MSC from other sources. Results of first clinical trials conducted to treat immune disorders are highlighted

Analgesia/Anesthesia in Reptiles

Nowadays, conducting clinical practice means dealing with a wide range of animal species, whose availability on the market is becoming more common and interest among owners is growing, which is why reptile patients may appear more often in the surgery. Due to the completely different nature of these animals, distinguishing them from the world of our most frequent patients, that is mammals, you must have the appropriate expertise to help them in accordance with the accepted international standards. We will often need general anesthesia, not only for surgical patients. Often, we must deal with aggressive and dangerous animals, which means that they require immobilization to ensure the safety of the staff, owners, and the suffering animal. The aim of this study is to familiarize the reader with the methods of conduct and methods of using analgesia and anesthesia in reptiles

W KRĘGU SUBKULTUR MŁODZIEŻOWYCH DRUGIEJ DEKADY XXI WIEKU

The aim of this article is to analyse subculture among youth in the second decade of the 21st century and to characterize determinants of subculture affiliation by research group examples. The theoretical part is based on the definition of subculture which was approved by the researchers including short descriptions of the research groups. In a later section authors, based on interviews which were conducted with representatives of particular subcultures, characterize the behaviour, appearance and feelings connected with subculture affiliation in an extensive way. The article also outlines the reasons why young people decide to join those subcultures and their value system within a specific sub culture, as perceived by each individual.Celem artykułu jest przeanalizowanie statusu subkultury wśród młodzieży drugiej dekady XXI wieku oraz scharakteryzowanie wyznaczników przynależności do niej na przykładzie badanych społeczności. Część teoretyczna traktuje o przyjętej przez badaczy definicji subkultury oraz krótkie charakterystyki badanych społeczności. W dalszej części autorzy pracy, na podstawie wywiadów przeprowadzonych z przedstawicielami konkretnych subkultur, w obszerny sposób charakteryzują zachowanie, wygląd i odczucia związane z przynależnością subkulturową. Artykuł przedstawia także przyczyny, dla których młodzi ludzie decydują się dołączyć do danej społeczności oraz indywidualnie postrzegany system wartości w obrębie konkretnych subkultur

Biobankowanie ludzkiego materiału biologicznego dla celów naukowych w Polsce i w Europie

Biobanks are one of the 10 Ideas Changing the World Right now – according to Time Magazine (2009). Samples and data deposition have become an increasing. trend in the world. Europe has invested a lot of money into infrastructures responsible for collection and storage of human biological samples. Poland, a country with a population of over 38.5 million people has just started investing funds into this powerful and indispensable tool for scientific research. Consortium of Polish Biobanks named as BBMRI.pl consisting of seven well-established biobanks developed a project for the Creation of the Polish Biobanking Network in order to organise our infrastructures according to world-recognized standards. The main tasks include: creation of Consortium of Polish Biobanks, development of IT solutions coherent with pan European needs, development of quality assurance tools, establishment of the Biobanking National Node, development of quality control programme and analysis of Ethical, Legal and Social Implications of research using human samples. Results of this project will increase Poland’s position in the international research arena of biomedicine, make our biorepositories open for international collaboration and in the future will contribute to the development of personalized medicine

The Thousand Polish Genomes—A Database of Polish Variant Allele Frequencies

Although Slavic populations account for over 4.5% of world inhabitants, no centralised, open-source reference database of genetic variation of any Slavic population exists to date. Such data are crucial for clinical genetics, biomedical research, as well as archeological and historical studies. The Polish population, which is homogenous and sedentary in its nature but influenced by many migrations of the past, is unique and could serve as a genetic reference for the Slavic nations. In this study, we analysed whole genomes of 1222 Poles to identify and genotype a wide spectrum of genomic variation, such as small and structural variants, runs of homozygosity, mitochondrial haplogroups, and de novo variants. Common variant analyses showed that the Polish cohort is highly homogenous and shares ancestry with other European populations. In rare variant analyses, we identified 32 autosomal-recessive genes with significantly different frequencies of pathogenic alleles in the Polish population as compared to the non-Finish Europeans, including C2, TGM5, NUP93, C19orf12, and PROP1. The allele frequencies for small and structural variants, calculated for 1076 unrelated individuals, are released publicly as The Thousand Polish Genomes database, and will contribute to the worldwide genomic resources available to researchers and clinicians