M-theory moduli spaces and torsion-free structures

Motivated by the description of $\mathcal{N}=1$ M-theory compactifications to four-dimensions given by Exceptional Generalized Geometry, we propose a way to geometrize the M-theory fluxes by appropriately relating the compactification space to a higher-dimensional manifold equipped with a torsion-free structure. As a non-trivial example of this proposal, we construct a bijection from the set of $Spin(7)$-structures on an eight-dimensional $S^{1}$-bundle to the set of $G_{2}$-structures on the base space, fully characterizing the $G_{2}$-torsion clases when the total space is equipped with a torsion-free $Spin(7)$-structure. Finally, we elaborate on how the higher-dimensional manifold and its moduli space of torsion-free structures can be used to obtain information about the moduli space of M-theory compactifications.Comment: 24 pages. Typos fixed. Minor clarifications adde

Supersymmetric AdS(4) compactifications of IIA supergravity

We derive necessary and sufficient conditions for N=1 compactifications of (massive) IIA supergravity to AdS(4) in the language of SU(3) structures. We find new solutions characterized by constant dilaton and nonzero fluxes for all form fields. All fluxes are given in terms of the geometrical data of the internal compact space. The latter is constrained to belong to a special class of half-flat manifolds.Comment: 24 pages, references adde

G_2 Domain Walls in M-theory

M-theory is considered in its low-energy limit on a G_2 manifold with non-vanishing flux. Using the Killing spinor equations for linear flux, an explicit set of first-order bosonic equations for supersymmetric solutions is found. These solutions describe a warped product of a domain wall in four-dimensional space-time and a deformed G_2 manifold. It is shown how these domain walls arise from the perspective of the associated four-dimensional N=1 effective supergravity theories. We also discuss the inclusion of membrane and M5-brane sources.Comment: 30 pages, Late

G-Structures, Fluxes and Calibrations in M-Theory

We study the most general supersymmetric warped M-theory backgrounds with non-trivial G-flux of the type R^{1,2} x M_8 and AdS_3 x M_8. We give a set of necessary and sufficient conditions for preservation of supersymmetry which are phrased in terms of G-structures and their intrinsic torsion. These equations may be interpreted as calibration conditions for a static ``dyonic'' M-brane, that is, an M5-brane with self-dual three-form turned on. When the electric flux is turned off we obtain the supersymmetry conditions and non-linear PDEs describing M5-branes wrapped on associative and special Lagrangian three-cycles in manifolds with G_2 and SU(3) structures, respectively. As an illustration of our formalism, we recover the 1/2-BPS dyonic M-brane, and also construct some new examples.Comment: 40 pages; v2: one reference added, typos correcte

The Virtual International Stroke Trials Archive

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses. METHODS: Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing. RESULTS: Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on \u3e15,000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 69+/-12 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials. CONCLUSIONS: This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning

Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of 9 trials

Background—Thrombolytic therapy with intravenous alteplase within 4.5 hours of ischemic stroke onset increases the overall likelihood of an excellent outcome (no, or nondisabling, symptoms). Any improvement in functional outcome distribution has value, and herein we provide an assessment of the effect of alteplase on the distribution of the functional level by treatment delay, age, and stroke severity. Methods—Prespecified pooled analysis of 6756 patients from 9 randomized trials comparing alteplase versus placebo/open control. Ordinal logistic regression models assessed treatment differences after adjustment for treatment delay, age, stroke severity, and relevant interaction term(s). Results—Treatment with alteplase was beneficial for a delay in treatment extending to 4.5 hours after stroke onset, with a greater benefit with earlier treatment. Neither age nor stroke severity significantly influenced the slope of the relationship between benefit and time to treatment initiation. For the observed case mix of patients treated within 4.5 hours of stroke onset (mean 3 hours and 20 minutes), the net absolute benefit from alteplase (ie, the difference between those who would do better if given alteplase and those who would do worse) was 55 patients per 1000 treated (95% confidence interval, 13–91; P=0.004). Conclusions—Treatment with intravenous alteplase initiated within 4.5 hours of stroke onset increases the chance of achieving an improved level of function for all patients across the age spectrum, including the over 80s and across all severities of stroke studied (top versus bottom fifth means: 22 versus 4); the earlier that treatment is initiated, the greater the benefit

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke

Background Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens — aspirin plus extendedrelease dipyridamole (ASA–ERDP) versus clopidogrel. Methods In this double-blind, 2-by-2 factorial trial, we randomly assigned patients to receive 25 mg of aspirin plus 200 mg of extended-release dipyridamole twice daily or to receive 75 mg of clopidogrel daily. The primary outcome was first recurrence of stroke. The secondary outcome was a composite of stroke, myocardial infarction, or death from vascular causes. Sequential statistical testing of noninferiority (margin of 1.075), followed by superiority testing, was planned. Results A total of 20,332 patients were followed for a mean of 2.5 years. Recurrent stroke occurred in 916 patients (9.0%) receiving ASA–ERDP and in 898 patients (8.8%) receiving clopidogrel (hazard ratio, 1.01; 95% confidence interval [CI], 0.92 to 1.11). The secondary outcome occurred in 1333 patients (13.1%) in each group (hazard ratio for ASA–ERDP, 0.99; 95% CI, 0.92 to 1.07). There were more major hemorrhagic events among ASA–ERDP recipients (419 [4.1%]) than among clopidogrel recipients (365 [3.6%]) (hazard ratio, 1.15; 95% CI, 1.00 to 1.32), including intracranial hemorrhage (hazard ratio, 1.42; 95% CI, 1.11 to 1.83). The net risk of recurrent stroke or major hemorrhagic event was similar in the two groups (1194 ASA–ERDP recipients [11.7%], vs. 1156 clopidogrel recipients [11.4%]; hazard ratio, 1.03; 95% CI, 0.95 to 1.11). Conclusions The trial did not meet the predefined criteria for noninferiority but showed similar rates of recurrent stroke with ASA–ERDP and with clopidogrel. There is no evidence that either of the two treatments was superior to the other in the prevention of recurrent stroke. (ClinicalTrials.gov number, NCT00153062.

Type IIA Orientifold Limit of M-Theory on Compact Joyce 8-Manifold of Spin(7)-Holonomy

We show that M-theory compactified on a compact Joyce 8-manifold of $Spin(7)$-holonomy, which yields an effective theory in $D = 3$ with $\N$ = 1 supersymmetry, admits at some special points in it moduli space a description in terms of type IIA theory on an orientifold of compact Joyce 7-manifold of $G_2$-holonomy. We find the evidence in favour of this duality by computing the massless spectra on both M-thory side and type IIA side. For the latter, we compute the massless spectra by going to the orbifold limit of the Joyce 7-manifold.Comment: 26 pages, 2 eps figures, Latex file, two references and one footnote added, corrected some typo

Scherk-Schwarz reduction of M-theory on G2-manifolds with fluxes

We analyse the 4-dimensional effective supergravity theories obtained from the Scherk--Schwarz reduction of M-theory on twisted 7-tori in the presence of 4-form fluxes. We implement the appropriate orbifold projection that preserves a G2-structure on the internal 7-manifold and truncates the effective field theory to an N=1, D=4 supergravity. We provide a detailed account of the effective supergravity with explicit expressions for the Kaehler potential and the superpotential in terms of the fluxes and of the geometrical data of the internal manifold. Subsequently, we explore the landscape of vacua of M-theory compactifications on twisted tori, where we emphasize the role of geometric fluxes and discuss the validity of the bottom-up approach. Finally, by reducing along isometries of the internal 7-manifold, we obtain superpotentials for the corresponding type IIA backgrounds.Comment: 43 pages, Latex; v3 typos corrected, one reference added, JHEP versio

Twisting K3 x T^2 Orbifolds

We construct a class of geometric twists of Calabi-Yau manifolds of Voisin-Borcea type (K3 x T^2)/Z_2 and study the superpotential in a type IIA orientifold based on this geometry. The twists modify the direct product by fibering the K3 over T^2 while preserving the Z_2 involution. As an important application, the Voisin-Borcea class contains T^6/(Z_2 x Z_2), the usual setting for intersecting D6 brane model building. Past work in this context considered only those twists inherited from T^6, but our work extends these twists to a subset of the blow-up modes. Our work naturally generalizes to arbitrary K3 fibered Calabi-Yau manifolds and to nongeometric constructions.Comment: 57 pages, 4 figures; uses harvmac.tex, amssym.tex; v3: minor corrections, references adde