Reciprocal template effects in a simple synthetic system

Two mutually-complementary templates are capable of catalysing the formation of each other, creating a framework for their reciprocal replication.</p

Probing Structural Effects on Replication Efficiency through Comparative Analyses of Families of Potential Self-Replicators

A formidable synthetic apparatus for the creation of nanoscale molecular structures and supramolecular assemblies through molecular structures can potentially be created from systems that are capable of parallel automultiplication (self-replication). In order to achieve this goal, a detailed understanding of the relationship between molecular structure and replication efficiency is necessary. Diastereoisomeric templates that are capable of specific and simultaneous autocatalysis have been synthesised. A systematic experimental and theoretical evaluation of their behaviour and that of structurally-related systems reveals the key determinants that dictate the emergence of self-replicative function and defines the structural space within which this behaviour is observed.</p

Specific autocatalysis in diastereoisomeric replicators

Two diastereoisomeric cycloadducts are capable of accelerating their own formation through the assembly of catalytic ternary complexes. The two cycloadducts do not have any measurable catalytic effect on the rate of formation of their diastereoisomer.</p

Comparative Analyses of a Family of Potential Self-Replicators: The Subtle Interplay between Molecular structure and the Efficacy of Self-Replication

It is envisioned that protocols based on self-replication will emerge as a formidable synthetic apparatus for the production of nanoscale assemblies through molecular structures that are capable of automultiplication with high reaction rates and selectivities. To achieve this goal, a complete understanding of the relationship between molecular structure and replication efficiency is necessary. Rigorous experimental and theoretical analyses of a series of self-complementary scaffolds that are intimately related in a constitutional sense, manufactured through the Diels-Alder reaction of complementary subunits, were undertaken. Experimental and computational methods were employed to map the key determinants that dictate the emergence of self-replicative function, as well as the efficiency, rate and selectivity of the self-replicative processes.</p