Classification of the line-soliton solutions of KPII

In the previous papers (notably, Y. Kodama, J. Phys. A 37, 11169-11190 (2004), and G. Biondini and S. Chakravarty, J. Math. Phys. 47 033514 (2006)), we found a large variety of line-soliton solutions of the Kadomtsev-Petviashvili II (KPII) equation. The line-soliton solutions are solitary waves which decay exponentially in $(x,y)$-plane except along certain rays. In this paper, we show that those solutions are classified by asymptotic information of the solution as $|y| \to \infty$. Our study then unravels some interesting relations between the line-soliton classification scheme and classical results in the theory of permutations.Comment: 30 page

IL-10 gene therapy prevents TNBS-induced colitis

The transfer of genes encoding immunomodulatory proteins to the intestinal mucosa is a promising new approach to the treatment of Crohn's disease (CD). This study investigates the therapeutic efficacy of an adenoviral vector encoding IL-10 (AdvmuIL-10) in experimental colitis. BALB/c mice were treated with a single intravenous injection of AdvmuIL-10, empty cassette virus (Adv0) or PBS prior to the induction of trinitrobenzene sulphonic acid (TNBS) colitis. AdvmuIL-10 treatment prevented the severe loss of body weight associated with TNBS administration. In addition, AdvmuIL-10 therapy led to a significant reduction in both stool markers of inflammation (IL-1beta and TNFR-II) and acute phase response (serum amyloid protein). Finally, the histological scores of mice with TNBS colitis treated with AdvmuIL-10 were significantly lower than Adv0- or PBS-treated controls. The therapeutic efficacy of AdvmuIL-10 was associated with a decrease in the IFN-gamma and IL-6 levels detected in colonic homogenates from mice with TNBS colitis, whereas no effect was observed on cytokine release from stimulated systemic lymphocytes. Thus, AdvmuIL-10 is an effective therapy in the TNBS model of colitis. Gene therapy strategies using adenoviral vectors encoding IL-10 may prove to be a potent therapy for chronic inflammatory conditions such as C