3 research outputs found
Observations on the Modified Wenker Synthesis of Aziridines and the Development of a Biphasic System
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher.
To access the final edited and published work see http://dx.doi.org/10.1021/jo302615gA cheap and reliable process for the modified Wenker cyclization to afford
aziridines has been achieved using biphasic conditions for a range of amino alcohol
starting materials. A 100 mmol “one-pot” process has also been devised and
enantiopurity of the starting amino alcohol is retained in the aziridine product