The analysis of the prognostic value of the neutrophil/ lymphocyte ratio and the platelet/lymphocyte ratio among advanced endometrial cancer patients

Objectives: About 20% of endometrial cancer (EC) patients have advanced disease (FIGO III & IV) at the moment of diagnosis.An attempt to evaluate the prognostic value of biochemical markers of inflammation and classic endometrial cancerprognostic factors in the group of advanced EC (aEC) patients has been made in this study.Material and methods: Records of 266 patients treated in the Maria Sklodowska-Curie Memorial Cancer Centre and Instituteof Oncology, Cracow Branch between the year 2006 and 2018 were included in the study. Follow-up ranged from 1 to138 months. Progression free survival (PFS) and overall survival (OS) have been set as endpoints. Tests such as: chi-squared,Fisher, log-rank, Mann-Whitney, Kruskal-Wallis and Cox proportional hazard ratio were used in the statistical analyses.Results: In the analysed group high total platelet count (PLT) before operative treatment and high levels of white blood cells(WBC), PLT, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) before adjuvant therapy (AT) have beensignificantly associated with shorter PFS and OS. After setting the cut-off values of NLR and PLR a statistically significantcorrelation between those parameters and PFS as well as OS has been shown. Multivariate analysis has indicated that NLRis an independent prognostic factor of the course of aEC.Conclusions: NLR and PLR correlate significantly with OS and PFS in aEC. NLR is an independent prognostic factor in thisgroup. It is possible to distinguish 3 risk groups, among aEC patients, based on NRL and PLR