Recoil Studies in the Reaction of 12-C Ions with the Enriched Isotope 118-Sn

The recoil properties of the product nuclei from the interaction of 2.2 GeV/nucleon 12-C ions from Nuclotron of the Laboratory of High Energies (LHE), Joint Institute for Nuclear Research (JINR) at Dubna with a 118-Sn target have been studied using catcher foils. The experimental data were analyzed using the mathematical formalism of the standard two-step vector model. The results for 12-C ions are compared with those for deuterons and protons. Three different Los Alamos versions of the Quark-Gluon String Model (LAQGSM) were used for comparison with our experimental data.Comment: 10 pages, 6 figures, submitted to Nucl. Phys.

Immunohistochemical evaluation of Ki-67, Cyclin D1 and β-catenin expression in the subtypes of triple negative breast cancer

Aim. To evaluate the expression levels of Ki-67 and cyclin D1 and β-catenin in the subtypes of triple negative breast cancer. Methods. The study was conducted on the surgical material from 60 patients of clinical stage 2A (T1N1M0 or T2N0M0) who were treated at the Rostov Research Institute of Oncology from 2012 to 2015. For immunohistochemistry, antibodies to estrogen and progesterone receptors, cytokeratins 5/6, Ki-67, cyclin D1, β-catenin, HER2/neu and EGFR proteins were used. Results. Triple negative breast cancer with the signs of basal epithelium was found to have a significantly higher expression level of Ki-67 compared to non-basal-like one. In some part of triple negative breast cancer samples overexpression of cyclin D1 was observed. The high level of cyclin D1 in the basal-like subtype was less common than in the subtypes without the signs of basal epithelium, but its average value was significantly higher. In triple negative cancer with cyclin D1 overexpression, the loss of β-catenin on the cell membrane and its abnormal accumulation in the cytoplasm was significantly more frequent. β-catenin translocation into the cell nucleus was observed only in basal-like triple negative cancer, and 2 times more often in case of cyclin D1 overexpression. Conclusion. In triple negative breast cancer tumors with overexpression of cyclin D1 and abnormal expression of β-catenin are observed in some cases; these biomarkers can be considered as potential therapeutic targets for this group of tumors

Sanitary Protection of the Territories within the Frames of Sanitary-Epidemiological Welfare Provision

Demonstrated is the structural and functional interrelation between sanitary protection of the territories, epidemiological monitoring, and the state sanitary-epidemiological surveillance. Sanitary protection of the territories (SPT) of the Russian Federation is a separate focus area authorizing sanitary prophylactic (anti-epidemic) activities, with a self-sustained sub-goal. It combines individual roles appertained to epidemiological monitoring and to federal sanitary-epidemiological surveillance, only in reference to a particular item - emergency situation in the sphere of sanitary-epidemiological welfare of the population. Specificity of the SPT is a balance between functionality and capacity of the monitoring, surveillance and control. Legislative and regulatory legal acts, which concern sanitary protection of the territory, provide the means for defining its basic organizational principles: country-wide activities, self-sufficiency and self-support of the Rospotrebnadzor, three-level hierarchical system, and information exchange

Improvement of the Normative-Regulatory Framework Concerning Anti-Epidemic Procedures for Works with Infectious Disease Agents in Mobile Laboratories of Specialized Anti-Epidemic Teams (SAET)

Carried out is a range of investigations aimed at the improvement of the anti-epidemic procedures for works with infectious disease agents (herein biological safety provision) in mobile laboratories of specialized anti-epidemic teams (SAET). Evaluation of the operational experience of stationary and field laboratories, as well as comparative analysis of the national safety requirements for works with pathogenic biological agents and WHO international regulations in the sphere of biological safety provision in laboratories, has made it possible to outline common for all types of microbiological laboratories principles for biosafety provision. With due consideration of these principles formulated are the core requirements for the provision of biological safety of SAET activities. Based on the results of biorisk and biohazard assessment which have to do with innovative mobile laboratories, worked out is a system of anti-epidemic procedures aimed towards establishment of the conditions that offer as low as practically achievable level of risk for personnel of SAET mobile laboratories, for population and human environment too. These practices, designed for biological safety provision among the personnel of mobile laboratories (ML), have been played back in a number of standard operational procedures. With a view to establishing of the environment with acceptable level of biorisk for the personnel and population when ML are used for various purposes and in various contingencies (in full force, single unit or several modules), worked out are the algorithms of decision-making support as regards selection of modules and optional accessories. However, there is a need for emergency response plans and training programs for the personnel on the provision of biosafety in ML to ensure and maintain acceptable level of biorisk connected with ML functioning

Critical Temperature for the Nuclear Liquid-Gas Phase Transition

The charge distribution of the intermediate mass fragments produced in p (8.1 GeV) + Au collisions is analyzed in the framework of the statistical multifragmentation model with the critical temperature for the nuclear liquid-gas phase transition $T_c$ as a free parameter. It is found that $T_c=20\pm3$ MeV (90% CL).Comment: 4 pages, 3 figures, published in Phys. Rev.

Improvement of the Preventive Measures for Managing Universiade-2013 Held in Kazan, Based on Comprehensive Evaluation of Epidemiological Risks as Regards Natural-Focal Infectious Diseases

Presented is the methodology for comprehensive evaluation of epidemiological risks (spatial and temporal characteristics, risk factors and cohorts) associated with natural-focal infectious diseases that pose a threat to sanitary-epidemiological welfare of the population within the frames of Universiade-2013. The event has been characterized from the viewpoint of mass gathering taking into consideration the complex of related threats to sanitary-epidemiological welfare of the population. Analyzed has been regional epidemiological situation on the currently important infections, whereas natural-focal infections have been assessed in reference to epidemiological risk. Based on the comprehensive evaluation with GIS software application differentiated have been the territories against the level of potential epidemiological hazard, put forward has been methodological approach to non-specific prophylaxis of natural-focal infectious diseases. Discussed have been the fundamentals of the approach, herewith it has been demonstrated that justified selection of internal threat and identification of spatial risk factors, as well as nature, scope and timing of the preventive measures ensure provision of favorable epidemiological situation as seen in the case of Universiade-2013

Basic Principles of Construction of Mobile Truck-Mounted Laboratories for Indication and Identification of Infectious Disease Agents

The paper covers historical retrospective of mobile truck-mounted laboratory construction, used for diagnostics of infectious diseases in the Russian Federation, as well as information on analogous laboratories of foreign manufacture. From the standpoint of systemic approach and systemic-functional analysis, investigated has been experience of the Russian Research Anti-Plague Institute “ Microbe” in developing mobile complexes for indication and identification of infectious disease agents, I-IV pathogenicity groups. Outlined, scientifically substantiated and considered in depth are ten basic principles, underlying design and construction of mobile laboratories for laboratory diagnostics of infectious diseases

Usage of Mobile Laboratories of Biological Expertise Abroad and in Russia: Present Day Realities and Prospects

We analyzed the data on availability and usage of mobile laboratories of biological expertise for indication and identification of pathogenic biological agents in foreign countries and in the Russian Federation. We outlined the major types of mobile units that exist abroad and in Russia. Key stages of evolution in design and deployment of mobile laboratories in the network of plague control institutions of the Rospotrebnadzor were described, as well as the broadening of the range of their use in Russia. We assessed operational use of the Russian mobile laboratories, both in Russia and abroad, in the provision of sanitary-epidemiological welfare during mass events, disaster management, and response to epidemic manifestations of particularly dangerous infectious diseases. Major trends in implementation of mobile units of biological expertise in Russia were identified. We addressed their usage in various State Programs on assistance to partner-countries in the matters of International Health Regulations (2005) implementation, control over dangerous infectious diseases. Advanced inventions – Second generation modernized mobile complex of the specialized anti-epidemic teams, mobile laboratory for monitoring and diagnostics, and airmobile anti-epidemic complex – were discussed