ENLIGHT:A consensus checklist for reporting laboratory-based studies on the non-visual effects of light in humans

Background: There is no consensus on reporting light characteristics in studies investigating non-visual responses to light. This project aimed to develop a reporting checklist for laboratory-based investigations on the impact of light on non-visual physiology. Methods: A four-step modified Delphi process (three questionnaire-based feedback rounds and one face-to-face group discussion) involving international experts was conducted to reach consensus on the items to be included in the checklist. Following the consensus process, the resulting checklist was tested in a pilot phase with independent experts. Findings: An initial list of 61 items related to reporting light-based interventions was condensed to a final checklist containing 25 items, based upon consensus among experts (final n = 60). Nine items were deemed necessary to report regardless of research question or context. A description of each item is provided in the accompanying Explanation and Elaboration (E&amp;E) document. The independent pilot testing phase led to minor textual clarifications in the checklist and E&amp;E document. Interpretation: The ENLIGHT Checklist is the first consensus-based checklist for documenting and reporting ocular light-based interventions for human studies. The implementation of the checklist will enhance the impact of light-based research by ensuring comprehensive documentation, enhancing reproducibility, and enabling data aggregation across studies. Funding: Network of European Institutes for Advanced Study (NETIAS) Constructive Advanced Thinking (CAT) programme; Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust, 204686/Z/16/Z); Netherlands Organisation for Health Research and Development VENI fellowship (2020–09150161910128); U.S. Department of Defense Grant (W81XWH-16-1-0223); National University of Singapore (NUHSRO/2022/038/Startup/08); and National Research Foundation Singapore (NRF2022-THE004-0002).</p

Match and Mismatch between Lived Experiences of Daytime Sleepiness and Diagnostic Instruments:A Qualitative Study amongst Patients with Sleep Disorders

Excessive daytime sleepiness is a common symptom of sleep disorders. Despite its prevalence, it remains difficult to define, detect, and address. The difficulties surrounding sleepiness have been linked to an ambiguous conceptualization, a large variety of scales and measures, and the overlap with other constructs, such as fatigue. The present study aims to investigate patients’ descriptions of sleepiness-related daytime complaints and their phenomenology. We performedsemi-directed interviews with patients diagnosed with obstructive sleep apnea (N = 15) or narcolepsy (N = 5). The interviewers took care of utilizing the participants’ terminology when describing daytime complaints related to their sleep disorder. Various aspects of the daytime complaints were investigated, such as their description and temporality. The transcribed content was thematicallyanalyzed using an eclectic coding system, yielding five themes. The participants used different interchangeable descriptors (tired, sleepy, fatigued, exhausted) to express their daytime complaints. They enriched their description with indexes of magnitude (ranging from ‘not especially’ to ‘most gigantic, extreme’), oppositions to other states (using antipodes like energy, alertness, wakefulness, orrest), and indications of fluctuations over the day. Interestingly, the participants often used metaphors to express their experiences and their struggles. The lived experiences of the patients were found to not always align with common self-reported monitoring tools of sleepiness and to relate only in part with current conceptions. In practice, it is important to probe daytime complaints, such as daytime sleepiness, with a broader consideration, for example, by exploring antipodes, consequences, and time-of-day fluctuations

An inventory of human light exposure behaviour

Light exposure is an essential driver of health and well-being, and individual behaviours during rest and activity modulate physiologically relevant aspects of light exposure. Further understanding the behaviours that influence individual photic exposure patterns may provide insight into the volitional contributions to the physiological effects of light and guide behavioural points of intervention. Here, we present a novel, self-reported and psychometrically validated inventory to capture light exposure-related behaviour, the Light Exposure Behaviour Assessment (LEBA). An expert panel prepared the initial 48-item pool spanning different light exposure-related behaviours. Responses, consisting of rating the frequency of engaging in the per-item behaviour on a five-point Likert-type scale, were collected in an online survey yielding responses from a geographically unconstrained sample (690 completed responses, 74 countries, 28 time zones). The exploratory factor analysis (EFA) on an initial subsample (n = 428) rendered a five-factor solution with 25 items (wearing blue light filters, spending time outdoors, using a phone and smartwatch in bed, using light before bedtime, using light in the morning and during daytime). In a confirmatory factor analysis (CFA) performed on an independent subset of participants (n = 262), we removed two additional items to attain the best fit for the five-factor solution (CFI = 0.95, TLI = 0.95, RMSEA = 0.06). The internal consistency reliability coefficient for the total instrument yielded McDonald’s Omega = 0.68. Measurement model invariance analysis between native and non-native English speakers showed our model attained the highest level of invariance (residual invariance CFI = 0.95, TLI = 0.95, RMSEA = 0.05). Lastly, a short form of the LEBA (n = 18 items) was developed using Item Response Theory on the complete sample (n = 690). The psychometric properties of the LEBA indicate the usability for measuring light exposure-related behaviours. The instrument may offer a scalable solution to characterise behaviours that influence individual photic exposure patterns in remote samples. The LEBA inventory is available under the open-access CC-BY license. Instrument webpage: https://leba-instrument.org/ GitHub repository containing this manuscript: https://github.com/leba-instrument/leba-manuscript

Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway

Vitamin D insufficiency is common in the healthy population. Recent insights addressed the role of vitamin D in serotonin and melatonin regulation, suggesting that increasing vitamin D status may be helpful for improving mood and sleep. This literature review covers the current state of evidence regarding potential effects of vitamin D on mood and sleep indicators in healthy people. In total, 11 observational studies were found for sleep, and 54 studies on mood (including ten RCTs). These studies revealed mixed results for both sleep and mood. The findings were interpreted based on the previously proposed serotonergic pathway of vitamin D. Implications and challenges for future research regarding the timing of blood sampling, timing and dosage of supplement intake and investigating the response dynamics are discussed

A systematic literature review on the rationale for and effects of dynamic light scenarios

The use of dynamic light scenarios for indoor environments may be motivated by the aim to support our circadian rhythms or provide a fascinating and/or informative environment. Additionally, dynamic lighting may be beneficial as it could acutely provide support at certain times of day, or for specific tasks or activities. A systematic literature search was performed to explore the dynamic scenarios that have been designed and tested to date. We explored what the motivations behind them were, and what the effectiveness of these scenarios was. On all aspects, the fourteen included articles varied substantially. The most promising effect seemed to be improved sleep due to an increased light dose during the day. However, for future work, it is recommended to explicitly explain and carefully align the theoretical rationale, the dynamic light scenario and the study protocol, including outcome measures. This review suggests potential beneficial effects of dynamic light scenarios on human functioning, but also clearly indicates that consolidated strategies for their description and assessment are currently lacking

Two experience sampling studies examining the variation of self-control capacity and its relationship with core affect in daily life

To facilitate a better understanding of the role of self-control capacity in self-control processes, we examined its variation at intraindividual and interindividual levels, and positioned it in a nomological network with core affect. In two experience sampling studies, 286 university students reported their self-control capacity and core affect for a week. Results revealed larger person-to-person than day-to-day variation in self-control capacity, while its moment-to-moment variation could be weakly modeled as a diurnal pattern. Interindividually, participants with higher self-control capacity were happier and less stressed, but intraindividually higher self-control capacity was mainly associated with higher alertness and energetic arousal. Our results imply that self-control capacity is better conceptualized as a composition of interrelated sub-constructs rather than as a unified resource

A systematic literature review on the rationale for and effects of dynamic light scenarios

The use of dynamic light scenarios for indoor environments may be motivated by the aim to support our circadian rhythms or provide a fascinating and/or informative environment. Additionally, dynamic lighting may be beneficial as it could acutely provide support at certain times of day, or for specific tasks or activities. A systematic literature search was performed to explore the dynamic scenarios that have been designed and tested to date. We explored what the motivations behind them were, and what the effectiveness of these scenarios was. On all aspects, the fourteen included articles varied substantially. The most promising effect seemed to be improved sleep due to an increased light dose during the day. However, for future work, it is recommended to explicitly explain and carefully align the theoretical rationale, the dynamic light scenario and the study protocol, including outcome measures. This review suggests potential beneficial effects of dynamic light scenarios on human functioning, but also clearly indicates that consolidated strategies for their description and assessment are currently lacking

Abrupt light transitions in illuminance and correlated colour temperature result in different temporal dynamics and interindividual variability for sensation, comfort and alertness

Detailed insights in both visual effects of light and effects beyond vision due to manipulations in illuminance and correlated color temperature (CCT) are needed to optimize study protocols as well as to design light scenarios for practical applications. This study investigated temporal dynamics and interindividual variability in subjective evaluations of sensation, comfort and mood as well as subjective and objective measures of alertness, arousal and thermoregulation following abrupt transitions in illuminance and CCT in a mild cold environment. The results revealed that effects could be uniquely attributed to changes in illuminance or CCT. No interaction effects of illuminance and CCT were found for any of these markers. Responses to the abrupt transitions in illuminance and CCT always occurred immediately and exclusively amongst the subjective measures. Most of these responses diminished over time within the 45-minute light manipulation. In this period, no responses were found for objective measures of vigilance, arousal or thermoregulation. Significant interindividual variability occurred only in the visual comfort evaluation in response to changes in the intensity of the light. The results indicate that the design of dynamic light scenarios aimed to enhance human alertness and vitality requires tailoring to the individual to create visually comfortable environments