Solubility Determination of Tris(hydroxymethyl)aminomethane in Water + Methanol Mixtures at Various Temperatures Using a Laser Monitoring Technique

Article on solubility determination of tris(hydroxymethyl)aminomethane in water + methanol mixtures at various temperatures using a laser monitoring technique

Solubility of Tris(hydroxymethyl)aminomethane in Methanol + 1-Propanol Mixtures at Various Temperatures

Article on the solubility of tris(hydroxymethyl)aminomethane in methanol + 1-propanol mixtures at various temperatures

Solubility of Tris(hydroxymethyl)aminomethane in Water + Methanol +1-Propanol Mixtures at Various Temperatures

Article on the solubility of tris(hydroxymethyl)aminomethane in water + methanol + 1-propanol mixtures at various temperatures

Solubility of Tris(hydroxymethyl)aminomethane in Water + 1-Propanol Mixtures at Various Temperatures

Article on the solubility of tris(hydroxymethyl)aminomethane in water + 1-propanol mixtures at various temperatures

An Improved Automated Setup for Solubility Determination of Drugs

Background: Solubility of a drug/drug candidate is an essential information in the pharmaceutical area. Classical solubility determination method used in the laboratories are expensive and time-consuming. Attempts were made to provide an automated solubility determination setup based on a laser monitoring technique. Methods: In a previously developed setup, drug powder was added to a given quantity of the solvent which made some troubles in practical applications. The present work reports another setup which adds solvent to a given mass of the drug. The validity of the measured solubilities is checked by comparing the measured solubilities of acetaminophen at two temperatures in water and ethanol mixtures with the corresponding data from the literature. Results: The results reveal that the improved setup could overcome the limitations of the previously developed setup and could be used for drug solubility determination. Conclusion: The improved setup overcomes the troubles made in the previous setup and could be used in generating large amount of solubility data to be used in the pharmaceutical industry

Solubility of Tris(hydroxymethyl)aminomethane in Water + 1-Propanol Mixtures at Various Temperatures

Article on the solubility of tris(hydroxymethyl)aminomethane in water + 1-propanol mixtures at various temperatures

Solubility of Tris(hydroxymethyl)aminomethane in Water + Methanol + 1-Propanol Mixtures at Various Temperatures

Article on the solubility of tris(hydroxymethyl)aminomethane in water + methanol + 1-propanol mixtures at various temperatures

Spectroscopic analysis of bosentan in biological samples after a liquid-liquid microextraction

Introduction: Microextraction processes with UV-Vis measurement have been developed and validated for analysis of bosentan in biological samples. Methods: In this work, liquid–liquid microextraction procedures (DLLME & USAEME) were employed for cleanup, pre-concentration, and determination of bosentan in biological samples by UV-Vis spectroscopy at 270 nm. The method was validated and applied to the determination of bosentan in spiked serum, exhaled breath condensate and urine samples. Results: Various experimental factors including type of extraction and dispersive solvents and their volumes, pH, sonication time and centrifuging time were investigated. Under the optimum conditions, the method was linear in the range of 1.0–5.0 μg.mL−1, with coefficient of determination (R2) of > 0.998. The limit of detection (LOD) was 0.07 mg.L−1. Recovery of the target analyte in biological samples was 106.2%. The method could be easily applied for higher concentration of bosentan and needs more improvement for application in the pharmacokinetic investigations where more sensitive methods are required. Conclusion: A simple, low cost, precise and accurate spectrophotometric analysis of bosentan in biological samples after liquid-liquid microextraction were developed and validated for routine analyses

Solubility Determination of Tris(hydroxymethyl)aminomethane in Water + Methanol Mixtures at Various Temperatures Using a Laser Monitoring Technique

Article on solubility determination of tris(hydroxymethyl)aminomethane in water + methanol mixtures at various temperatures using a laser monitoring technique