Synthesis , Characterization and Antibacterial Activities of Co (II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II) Mixed-Ligand Complexes of L-Proline and Trimethoprim antibiotic

The Co(II), Ni(II) ,Cu(II), Zn(II) ,Cd(II) and Hg(II) complexes of mixed of amino acid  (L-Proline ) and Trimethoprim antibiotic were synthesized. The complexes were characterized using solubility, melting  point, conductivity measurement   ,. and determination  the percentage of  the metal  in  the  complexes  by  flame(AAS).Magnetic susceptibility, Spectroscopic Method [FT-IR and UV-Vis].    Draw the proposed structure of the complexes using program ,  Chem. office 3D(2006). The   ligands   and  there metal complexes were  screened  for  their antimicrobial activity against  four bacteria (gram + ve) and (gram -ve){Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus}.The proposed structure of the complexes using program , Chem office 3D(2006).The general formula have been given for the prepared mixed ligand complexes   [M(Pro)2(TMP)(H2O)]where   L-Proline (abbreviated as  (ProH ) = C5H9NO2 And   Pro- = C5H8NO2 deprotonated  primary ligand, L-proline  . Trimethoprim (abbreviated as  (TMP ) =C10H11N3O3S . Keywords: Trimethoprim antibiotic, L-Proline   , Spectral and antibacterial activities.

Synthesis, Physico-Chemical and Antimicrobial Activities Co(II),Ni (II) ,Cu(II), Zn(II),Cd(II) and Hg(II) Mixed- Ligand Complexes of L- Alanine and Trimethoprim Antibiotic

The Co (II), Ni (II) ,Cu(II), Zn(II) ,Cd(II) and Hg(II) complexes of mixed of amino acid (L-Alanine ) and Trimethoprim antibiotic were synthesized. The complexes were characterized using melting point, conductivity measurement and determination the percentage of the metal in the complexes by flame (AAS). Magnetic susceptibility, Spectroscopic Method [FT-IR and UV-Vis]. The general formula have been given for the prepared mixed ligand complexes [M(Ala)2(TMP)(H2O)] where  L- alanine (abbreviated as (Ala ) = (C5H9NO2) deprotonated primary ligand, L- Alanine ion .= (C5H8NO2-) Trimethoprim (abbreviated as  (TMP ) = C10H11N3O3S M(II) = Co (II),Ni(II) ,Cu(II), Zn(II) ,Cd(II) and Hg(II). The results showed that the deprotonated L- Alanine by KOH (Ala- K+) act as uni nagative bi dentate  ligand , was coordinated to the metal ions through the oxygen of the carboxylic group (-COO-), and the nitrogen of the amine group (-NH2) while Trimethoprim antibiotic act as  mono dentate ligand , was coordinated to the metal ions through the nitrogen of the pyrimidine group. Keywords: Trimethoprim antibiotics , L- Alanine) complexes & Antibacterial activit

Synthesis, Characterization and Biological Activity of Schiff Bases Chelates with Mn(II),Co(II),Ni (II),Cu(II) and Hg(II)

In this paper, some series of new complexes of Mn(II), Co(II), Ni (II) Cu(II) and Hg(II) are prepared from the Schiff bases (L1,L2). (L1) derived from 4-aminoantipyrine and O-phenylene dia mine then (L2) derived from (L1) and 2-benzoyl benzoic acid. Structural features are obtained from their elemental microanalyses, molar conductance, IR, UV–Vis, 1H, 13CNMR spectra and magnetic susceptibility. The magnetic susceptibility and UV–Vis, IR spectral data of the ligand (L1) complexes get square–planar and tetrahedral geometries and the complexes oflig and (L2) get an octahedral geometry. Antimicrobial examinations show good results in the sharing complexes