Liver and Kidney Biochemical Markers in Alloxan Induced Diabetic Wistar Rats: Effects of Buchholzia coriacea Seed Alcoholic Extract

The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs. Therefore, the objective of this paper was to assess the effects of wonderful kola (Buchholzia coriacea) on biochemical markers such as liver and kidney in alloxan induced diabetic Wistar rats using appropriate standard techniques. The result showed that Buchholzia coriacea seed extract caused significant (p<0.05) reduction in the levels of glucose. The liver function test revealed notable changes in the negative control group compared to the control group, including elevated levels of AST, ALT, ALP, and T.P (*p<0.05). Treatment with Metformin and the high dose of Wonderful Kola exhibited significant improvements in AST, ALT, and ALP levels compared to the negative control (#p<0.05), suggesting potential hepatoprotective effects. The  kidney function test, revealed notable difference In comparison to the control group, the negative control group showed significantly (p<0.05) elevated levels of Urea, Creatinine, K, Na, Cl, T.B, and C.B. Treatment with Metformin demonstrated a significant (p<0.05) decrease in Urea and Creatinine levels compared to the negative control. The low and high doses of Wonderful Kola resulted in significant (p<0.05) reductions in Urea, Creatinine, and T.B levels, with the high dose also significantly decreasing Na and Cl levels compared to the negative control. The methanoic extract of Buchholzia coriacea seed possess hypoglycemic properties and may therefore be beneficial in the management of diabetes mellitus at the above dosage and treatment period. Buchholzia coriacea especially at high doses exhibited protective effects on the liver and kidney biochemical markers in alloxan induced diabetic rats, highlighting its potential as a therapeutic agent

Ten Years After: An ‘Austerity Audit’ of Services and Living Conditions for People Living with HIV in the UK, a Decade after the Financial Crisis

Cite as: HIV Psychosocial Network (2018). Ten Years After: An ‘Austerity Audit’ of Services and Living Conditions for People Living with HIV in the UK, a Decade after the Financial Crisis

Knowledge Management and Organisational Resilience of Pre-Shipment Inspection Companies in South South, Nigeria

The study examined the nexus between knowledge management (dimensioned by knowledge sharing and knowledge storage) and organisational resilience (measured by adaptability) of pre-shipment inspection companies in South-South, Nigeria. The upper echelons theory underpinned the study, while the underlying philosophy is positivism. The cross-sectional survey was adopted in generating primary data through the use of questionnaire. The elements of the accessible population are the 480 middle and top-level managers of all the 20 Pre-Shipment Inspection Companies, in South-South, Nigeria, and a sample size of 235 respondents was determine. The hypotheses were tested at 0.05 significance level, using partial least square-structural equation modeling. The study concludes that when management increases the adoption of knowledge management, the tendency for organisational resilience will be enhanced. It is therefore recommended that managers of Pre-Shipment Inspection companies in South South, Nigeria, should enhance the implementation of knowledge sharing in order to bring about adaptability of the organisation. This can be achieved by conducting regular meetings to exchange experiences, using newsletters to disseminate information and ensuring knowledgeable staff share their ideas with other staff. Moreso, Management of Pre-Shipment Inspection companies in South-South, Nigeria, should improve their knowledge storage practices as a means of increasing the level of adaptability in the organisations. This can be achieved by having a system for keeping and retrieving information, ensuring staff have access to required information

Knowledge Management and Organisational Resilience of Pre-Shipment Inspection Companies in South South, Nigeria

The study examined the nexus between knowledge management (dimensioned by knowledge sharing and knowledge storage) and organisational resilience (measured by adaptability) of pre-shipment inspection companies in South-South, Nigeria. The upper echelons theory underpinned the study, while the underlying philosophy is positivism. The cross-sectional survey was adopted in generating primary data through the use of questionnaire. The elements of the accessible population are the 480 middle and top-level managers of all the 20 Pre-Shipment Inspection Companies, in South-South, Nigeria, and a sample size of 235 respondents was determine. The hypotheses were tested at 0.05 significance level, using partial least square-structural equation modeling. The study concludes that when management increases the adoption of knowledge management, the tendency for organisational resilience will be enhanced. It is therefore recommended that managers of Pre-Shipment Inspection companies in South South, Nigeria, should enhance the implementation of knowledge sharing in order to bring about adaptability of the organisation. This can be achieved by conducting regular meetings to exchange experiences, using newsletters to disseminate information and ensuring knowledgeable staff share their ideas with other staff. Moreso, Management of Pre-Shipment Inspection companies in South-South, Nigeria, should improve their knowledge storage practices as a means of increasing the level of adaptability in the organisations. This can be achieved by having a system for keeping and retrieving information, ensuring staff have access to required information