A Journal Club: A Scholarly Community for Preservice and Inservice Science Teachers

This qualitative case study examines how a journal club can be used as a pedagogical tool in science teacher education. Six preservice and inservice science teachers, for seven months, participated in a journal club where they chose, read, and discussed science education research articles from problems or concerns they had in their teaching practice. The data included field notes, audio-recordings of meetings, pre- and post- interviews with all the teachers, two focus groups, artifacts collected (e.g. journal articles, reflective paper, e-mail exchanges, and researcher’s field notes). The data were analyzed using the techniques of grounded theory (Corbin & Strauss, 2008). Unlike grounded theory, I also used preconceived categories created from existing literature on journal clubs and communities of practice (Newswander & Borrego, 2009; Tallman & Feldman, 2012; Wenger, 1998). The findings reveal the journal club functioned as a community of practice where the teachers learned how to search for and critique research articles and participated in discussions that examined the implications of educational theory to their practice. The teachers engaged in scholarly talk. Scholarly talk was defined as using three modes of collaborative discourse: critically analyzing a research article, sharing teacher anecdotes, and weighing different perspectives through exploratory talk. In the journal club, these conversations helped the teachers learn about their teaching practice and reflect on how to bring changes to their practice. It is through the collaborative conversations in the journal club that all the teachers began to examine teaching through a new lens. The findings suggest the teachers embraced the educational theory read in the journal club. They welcomed being scholars in the journal club and forming a professional network among inexperienced and experienced science teachers. The journal club provided the teachers the tools to engage with intellectual concepts and become critical thinkers and consumers of theoretical knowledge

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia.

Acute myeloid leukemia (AML) cells meet the higher energy, metabolic, and signaling demands of the cell by increasing mitochondrial biogenesis and mitochondrial protein translation. Blocking mitochondrial protein synthesis through genetic and chemical approaches kills human AML cells at all stages of development in vitro and in vivo. Tigecycline is an antimicrobial that we found inhibits mitochondrial protein synthesis in AML cells. Therefore, we conducted a phase 1 dose-escalation study of tigecycline administered intravenously daily 5 of 7 days for 2 weeks to patients with AML. A total of 27 adult patients with relapsed and refractory AML were enrolled in this study with 42 cycles being administered over seven dose levels (50-350 mg/day). Two patients experienced DLTs related to tigecycline at the 350 mg/day level resulting in a maximal tolerated dose of tigecycline of 300 mg as a once daily infusion. Pharmacokinetic experiments showed that tigecycline had a markedly shorter half-life in these patients than reported for noncancer patients. No significant pharmacodynamic changes or clinical responses were observed. Thus, we have defined the safety of once daily tigecycline in patients with refractory AML. Future studies should focus on schedules of the drug that permit more sustained target inhibition

Association between adherence to radiation therapy quality metrics and patient reported outcomes in prostate cancer.

BACKGROUND: Prior studies have shown significant variability in the quality of prostate cancer care in the US with questionable associations between quality measures and patient reported outcomes. We evaluated the impact of compliance with nationally recognized radiation therapy (RT) quality measures on patient-reported health-related quality of life (HRQOL) outcomes in the Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) cohort. METHODS: CEASAR is a population-based, prospective cohort study of men with localized prostate cancer from which we identified 649 who received primary RT and completed HRQOL surveys for inclusion. Eight quality measures were identified based on national guidelines. We analyzed the impact of compliance with these measures on HRQOL assessed by the 26-item Expanded Prostate Index Composite at pre-specified intervals up to 5 years after treatment. Multivariable analysis was performed controlling for demographic and clinicopathologic features. RESULTS: Among eligible participants, 566 (87%) patients received external beam radiation therapy and 83 (13%) received brachytherapy. Median age was 69 years (interquartile range: 64-73), 33% had low-, 43% intermediate-, and 23% high-risk disease. 28% received care non-compliant with at least one measure. In multivariable analyses, while some statistically significant associations were identified, there were no clinically significant associations between compliance with evaluated RT quality measures and patient reported urinary irritative, urinary incontinence, bowel, sexual or hormonal function. CONCLUSIONS: Compliance with RT quality measures was not meaningfully associated with patient-reported outcomes after prostate cancer treatment. Further work is needed to identify patient-centered quality measures of prostate cancer care

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs

Comment in Lowering the High Cost of Cancer Drugs--III. [Mayo Clin Proc. 2016] Lowering the High Cost of Cancer Drugs--I. [Mayo Clin Proc. 2016] Lowering the High Cost of Cancer Drugs--IV. [Mayo Clin Proc. 2016] In Reply--Lowering the High Cost of Cancer Drugs. [Mayo Clin Proc. 2016] US oncologists call for government regulation to curb drug price rises. [BMJ. 2015

A Multicenter Randomized Clinical Trial Evaluating Interleukin-2 Activated Hematopoietic Stem Cell Transplantation and Post-transplant IL-2 for High Risk Breast Cancer Patients

This Phase III randomized multicenter trial compared progression-free (PFS) and overall survival (OS) for autologous peripheral blood stem cell (aPBSC) transplantation with or without immunotherapy in high-risk breast cancer patients.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44232/1/10549_2005_Article_4445.pd

Driving performance in mild dementia

The automobile driving performance of 18 mildly demented subjects was compared to that of 18 normal elderly and 18 mid-age controls. Driving tasks were grouped according to a three-level hierarchical model that characterizes driving as a problem solving skill involving (a) low-level vehicle control skills, (b) intermediate level manoeuvring skills in response to on-road events, and (c) higher level driving-related judgemental abilities. Driving simulator measures of brake reaction time and steering accuracy were selected to represent the lowest level of hierarchy. A Motor Vehicle Branch (MVB) road test and a test of emergency braking distance indexed the intermediate level. Driving-related judgment was assessed by evaluating the accuracy of subjects' appraisals of their own driving skills, and by examining whether the demented subjects evidenced an increased level of driving avoidance that might be commensurate with the extent of their driving deficits. Overall the demented subjects performed significantly less well than did controls on the driving behaviour measures. Particularly striking were their deficits at the highest and lowest levels of the hierarchical task analysis. They were markedly impaired on the driving simulator tasks and they showed a clear tendency to over-estimate their driving competence relative to their actual performance. However, from a practical standpoint it was noted that despite significant group differences at the intermediate level, the overlap in performance scores between the demented and the normal elderly was considerable for these in-car tasks. Also, although the mildly demented subjects had significantly more demerit points on the MVB road test than did the elderly controls, nearly 70% were able to pass the licensing exam. Mildly demented drivers might best be characterized as having marginal driving abilities, a fact which may pose considerable challenges to clinicians and policy makers. A second component of the study involved evaluation of the correlations between the driving measures and several common psychometric tests of attention, perception, and psychomotor speed. After group membership was accounted for, the psychometric tests failed to add precision to the prediction of driving performance.Arts, Faculty ofPsychology, Department ofGraduat

Lateral ventricle size, smooth pursuit eye tracking and neuropsychological test performance in chronic schizophrenia

The relationships between lateral ventricle size, smooth pursuit eye tracking, and neuropsychological test performance were investigated using a sample of 30 chronic schizophrenic inpatients. There were no significant correlations between any of the measures. Compared to a control group of normal volunteers, the schizophrenic patients showed abnormally poor eye tracking accuracy but did not show lateral ventricular enlargement. Compared to a group of age matched non-schizophrenic psychiatric patients, the schizophrenic patients were impaired on six out of ten neuropsychological tests. As there was no evidence of lateral ventricle enlargement, it is clear that eye tracking impairment and deficits on neuropsychological tests may occur independently of enlarged lateral ventricles. The absence of relationships between impairments on the neuropsychological tests and poor eye tracking is not thought to be the result of restricted performance ranges for any of the measures. The most parsimonious conclusion is that there is no relationship between eye tracking and the variety of neuropsychological functions assessed in this study. However, an alternative possibility is that the study sample was too homogeneously impaired, and a relationship between eye tracking impairment and neuropsychological deficits might emerge in a more diverse sample representative of the range of individuals currently diagnosed as schizophrenic.Arts, Faculty ofPsychology, Department ofGraduat

The Use of Journal Clubs in Science Teacher Education

This qualitative study explored how in a 7-month-long journal club pre- and inservice science teachers engaged with education research literature relevant to their practice to reduce the theory–practice gap. In the journal club they had the opportunity to critique and analyze peer-reviewed science education articles in the context of their classroom practice. Data sources included audio recordings of the meetings; semi-structured pre- and post-interviews of the teachers; focus groups; and artifacts (e.g., journal articles, reflective paper, email exchanges, and researcher’s field notes). Data were analyzed using the techniques of grounded theory (Corbin & Strauss in Basics of qualitative research, 3rd ed. Sage, Thousand Oaks, 2008). In addition we used some preconceived categories that we created from existing literature on journal clubs and communities of practice (Newswander & Borrego in European Journal of Engineering Education 34(6): 561–571, 2009; Wenger in Communities of practice: learning, meaning, and identity. Cambridge University Press, Cambridge, 1998) and from our previous research (Tallman & Feldman, 2012). We found that the journal club incorporated the three characteristics of a community of practice (Wenger in Communities of practice: learning, meaning, and identity. Cambridge University Press, Cambridge, 1998) into its functioning (mutual engagement, joint enterprise, and shared repertoire). The teachers mutually engaged around the joint enterprise of reading, critiquing, and understanding the research studies with the goal of improving practice. The teachers also asked each other analytical questions, which became a shared repertoire of the journal club. They reflected on their practice by presenting, reading, and discussing the articles, which helped them to determine whether and how the findings from the articles could be incorporated into their teaching practice. In doing so, they learned the skills needed to critique the research literature in relation to their practice as classroom teachers

The "Research Jury Method": The Application of the Jury Trial Model to Evaluating the Validity of Descriptive and Causal Statements about Psychotherapy Process and Outcome

A rationale for using a qualitative "Research Jury Method" for assessing psychotherapy outcome as an alternative to randomized controlled trials is given. It is argued that the jury research method is compatible with scientific practice and that science itself relies on the method. Methods and results from two preliminary studies are briefly summarized. In the current study three jurors evaluated a rich case history to decide (a) whether the client changed, and (b) to what degree, and how, psychotherapy contributed. Results suggest the method can be a useful way of assessing psychotherapy outcome and can produce differentiated insights into case-specific changes and change processes. A conclusion is that we can draw inferences and make plausible cases that people change in psychotherapy and that therapy contributes to it from individual cases using rich data, qualitative analysis, and a jury method. In addition, we can learn things from this method that one cannot learn as easily from randomized controlled trials.