Teaching and Learning Courageous Followership: An Action Research Study

Followership has been shown to be a developmental stage of leadership. Yet, there is a lack of followership theory in the health-care context. The purpose of this qualitative action research study was to explore how introducing Chaleff’s dimensions of courageous followership influences the undergraduate nursing students’ views of the follower role and informs their nursing practice. Secondary research questions asked how knowledge of these dimensions influences the nursing students’ views while advocating, collaborating, and addressing lateral violence. Using purposeful sampling, 12 participants were recruited for this study. After attending a followership seminar, they completed online reflections and participated in individual and focus group interviews. Other data collection methods used were field notes and a researcher’s reflective journal. Domain analysis, transcription, memo writing, axial coding, and thematic analysis were used to analyze the data. Brinkmann and Kvale’s stages of validation guided interview validity. And Herr and Anderson’s criteria for action research validity guided design validity. In summary of this study’s findings, learning followership was found to influence students’ views by providing a new understanding of accountability, responsibility, and power to initiate action and engage in exemplary behaviors when advocating and collaborating. Willingness or unwillingness to follow was situational to contextual factors, and influenced students’ sense of engagement. Lived experiences were also seen to influence students’ engagement and sense of power, and provided participants with a sense of certainty to move forward in their advocating and collaborating attempts. Finally, sight was identified as students’ strength when advocating for others

Individualism-Collectivism and Power Distance Cultural Dimensions: How Each Influences Parental Disciplinary Methods

Abstract This paper is a literature review using the Douglas-Widavasky Grid/Group theory as a framework to examine, from a cross cultural perspective, preferred parental disciplinary methods. The four rival cultures defined in the Grid/Group theory mirror the cultural dimensions of individualism-collectivism and power distance described by Geert Hofstede. Each of these rival cultures has distinct parenting styles, including disciplinary methods. When trying to predict a preferred disciplinary method based on a parent's country of origin, knowing the country's score under Hofstede's dimensions allows easier assignment to one of the four cultures in the Grid/Group theory. Once assigned to one of the Grid/Group's four cultures, the preferred disciplinary method can be easily identified. For this review, the Global Leadership and Organizational Effectiveness (GLOBE) study's ten societal clusters were used as a starting point to identify countries with similar individualism-collectivism and power distance rankings. Findings of this review reinforce the proposed approach. However, the review is limited by the small number of studies focusing specifically on disciplinary methods. Most examine parenting style and do not take into account "modernized" disciplinary methods secondary to immigration

The University of Utah\u27s Integrated Core: A case study from a commuter campus

This paper describes the Integrated Core (IC), the University of Utah’s version of integrated curricula. We begin with a rationale for the IC, providing a background on the unique student demographics, and University-wide requirements that propelled our design. Our IC focuses specifically on active living, sustainability, and social justice as target outcomes of parks, recreation, and tourism services and experiences. This rationale is followed by an outline of both the structure and implementation of the IC, including a discussion of sample assignments (incorporating both experiential learning and community engagement). Following a discussion of feedback after two years of delivering the IC, relaying benefits as well as challenges, we end with suggestions for future improvements

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody.

Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor initiation, and/or metastasis. Breast cancer cells that express the type I tyrosine kinaselike orphan receptor ROR1 also may have such features. Here we find that the expression of ROR1 increased in breast cancer cells following treatment with chemotherapy, which also enhanced expression of genes induced by the activation of Rho-GTPases, Hippo-YAP/TAZ, or B lymphoma Mo-MLV insertion region 1 homolog (BMI1). Expression of ROR1 also enhanced the capacity of breast cancer cells to invade Matrigel, form spheroids, engraft in Rag2-/-[Formula: see text] mice, or survive treatment with paclitaxel. Treatment of mice bearing breast cancer patient-derived xenografts (PDXs) with the humanized anti-ROR1 monoclonal antibody cirmtuzumab repressed expression of genes associated with breast cancer stemness, reduced activation of Rho-GTPases, Hippo-YAP/TAZ, or BMI1, and impaired the capacity of breast cancer PDXs to metastasize or reengraft Rag2-/-[Formula: see text] mice. Finally, treatment of PDX-bearing mice with cirmtuzumab and paclitaxel was more effective than treatment with either alone in eradicating breast cancer PDXs. These results indicate that targeting ROR1 may improve the response to chemotherapy of patients with breast cancer

Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing

Ultra-deep targeted sequencing (UDT-Seq) can identify subclonal somatic mutations in tumor samples. Early assays' limited breadth and depth restrict their clinical utility. Here, we target 71 kb of mutational hotspots in 42 cancer genes. We present novel methods enhancing both laboratory workflow and mutation detection. We evaluate UDT-Seq true sensitivity and specificity (> 94% and > 99%, respectively) for low prevalence mutations in a mixing experiment and demonstrate its utility using six tumor samples. With an improved performance when run on the Illumina Miseq, the UDT-Seq assay is well suited for clinical applications to guide therapy and study clonal selection in heterogeneous samples

Single slice vs. volumetric MR assessment of visceral adipose tissue: reliability and validity among the overweight and obese.

To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.Visceral adipose tissue (VAT) is associated with abnormal cardiovascular and metabolic profiles. Total VAT volume of the abdominal compartment by magnetic resonance imaging (MRI) is the gold-standard measurement for VAT but is costly and time consuming. Prior studies suggest VAT area on a single slice MR image may serve as a surrogate for total VAT volume but it is unknown if this relationship is maintained in overweight and obese men and women. Untreated sleep apnea subjects enrolled into the Icelandic Sleep Apnea Cohort (ISAC) underwent abdominal MRI. VAT area and subcutaneous adipose tissue (SAT) area at the L2-L3 and L4-L5 interspaces and total VAT and SAT volumes were determined by manual examination using image analysis software; 539 men and 129 women with mean ages of 54.1 and 58.8 years and mean BMI of 32.2 kg/m(2) and 33.7 kg/m(2), respectively, were studied. Mean total VAT volume was 40% smaller and mean total SAT was 25% larger among females compared with males. The correlation with VAT volume was significantly larger for L2-L3 VAT area (r = 0.96) compared to L4-L5 VAT area (r = 0.83). The difference in correlation coefficients was statistically significant (nonparametric bootstrap P < 0.001 with 95% confidence interval (CI) for the difference from 0.11 to 0.15. VAT area at L2-L3 was also significantly better correlated with VAT volume than traditional anthropometric variables. Linear regression analyses demonstrated that L2-L3 area alone was sufficient for predicting total VAT volume and that the nature of the linear association was maintained across all levels of obesity and in both genders.NIH HL070267 HL09430

Soldiers Returning from Deployment: A Qualitative Study Regarding Exposure, Coping, and Reintegration

Purpose/Objective: The purpose of this study was to qualitatively explore exposure to deployment-related physical and/or emotional trauma and associated symptoms among Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) soldiers. Interviews also focused on in-theater- and reintegration-related experiences. Research Method/Design: OEF/OIF soldiers (N = 103) participated in semistructured interviews, and a qualitative descriptive methodology was used to analyze the data. Results: Themes were identified regarding (a) common experiences related to emotional and physical traumas and associated symptoms and strategies for coping and making meaning of experiences and (b) how combat and reintegration experiences affected soldiers’ senses of self, relationships with others, and functioning. Conclusions/Implications: Themes identified support a rethinking of deployment-related mild traumatic brain injury and posttraumatic stress disorder as discrete conditions. Dimensional versus categorical models should be considered. The findings also highlight experiences and potentially meaningful constructs (e.g., moral injury, moral repair) that can be used to inform research and clinical efforts aimed at improving the lives of those who have serve

Long-Term Effects of Inhaled Budesonide for Bronchopulmonary Dysplasia

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