4,812 research outputs found

    Looking for the X-factors: Contextualised learning and young Indigenous Australian children

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    This presentation outlines a research project into early childhood education funded by Queensland Department of Education and Training’s Education Horizon research grant scheme. The project will run from July 2016 to June 2017. This project involved two main research activities: an online survey of early childhood educators of young Indigenous Australians and a small case study of early childhood and early years education programs in Logan, Darling Downs and Far North Queensland regions. The pilot case study sought to identify ‘X-factors’ regarding the contextualisation of curriculum, pedagogy and assessment for young Indigenous Australian learners. This presentation will outline the case study model, describe and discuss the findings of the research at Cherbourg State School (Darling Downs region, Qld). It will outline initial findings and elements regarding experiences, expectations and praxis that underpinned the decision-making of parents, educators and school leaders

    Improving customer satisfaction through the management of perceptions of waiting

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    Thesis (M.S.)--Massachusetts Institute of Technology, Sloan School of Management, 1989.Includes bibliographical references (leaves 112-113).by Karen L. Katz and Blaire R. Martin.M.S

    Daily Sleep Quality is Associated with Daily Cognition in Late-Life

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    Background: Older adults often face sleep disturbance or cognitive decline that goes beyond the scope of normal aging. The present study examined the relationship between self-reported sleep quality and self-reported daytime attention in a community-dwelling sample of older men at the between-persons and within-persons levels of association. Methods: Thirty-eight participants (M age =75.36 years, SD age =7.51 years, range=66-90 years) completed a twice-daily sleep diary for one week. Sleep quality and attention were assessed using a single-item 0-10 rating scales from the morning diary (“How was the quality of your sleep last night?”) and from the evening diary (“How was your attention today?”). A two-level multilevel model was parameterized with days nested within individuals to examine whether nightly sleep quality predicts an individual’s daily attention rating. Results: A multilevel model predicting self-reported attention revealed (1) older individuals who reported better sleep quality reported having better daily attention [Beta=0.64, t(248.15)=10.12, p\u3c0.001] and (2) following a day of above-average sleep quality, older individuals experienced above-average attention [Beta=0.16, t(259.79)=2.75, p=.006]. Conclusion: Not only was overall sleep quality associated with self-reported attention, but a good night\u27s sleep was associated with better self-reported next-day attention. Results point to the potential importance of fluctuations in sleep quality for daytime functioning. Interventions aimed at improving nightly sleep consistency may be worth exploring as methods to improve daytime cognitive functioning in older adults. Support: This work was supported by the Sleep Research Society Foundation/Jazz Pharmaceuticals (001JP13, PI: Dzierzewski) and by the National Institute on Aging of the National Institutes of Health under Award Number K23AG049955 (PI: Dzierzewski), and National Heart Lung and Blood Institute at the National Institutes of Health under award number K24HL143055 (PI: Martin). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the Department of Veterans Affairs.https://scholarscompass.vcu.edu/gradposters/1089/thumbnail.jp

    Severe Hyperlipidemia Induced Hemorrhagic Pancreatitis during Pregnancy

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    Background. We report a case of familial hyperlipidemia in pregnancy that resulted in hemorrhagic pancreatitis. Case. A patient at 27-week gestation was admitted for recurrent pancreatitis secondary to severe hyperlipidemia. With conservative care, the patient improved but on the fourth day of admission she experienced a sudden onset of hypotension and was diagnosed with hemorrhagic pancreatitis. Conclusion. Pancreatitis caused by hyperlipidemia is an uncommon event during pregnancy. A familiarity with the severe complications associated with this potentially life-threatening condition is important

    Enzymatic Activity in the Chorion for Hatching in the California Grunion

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    Leuresthes tenuis is a small, silverside fish that spawns on the beaches during some of the highest tides of the summer months. Of the many unique traits to the species including that the eggs develop fully out of water to the point of hatching competence but will not hatch until presented with an environmental cue, which causes them to hatch in less than a minute. The purpose of this study is to better understand the role of enzymes called chorionases, which act to break down the chorion (egg membrane). I hypothesize that the chorion begins to weaken in this species when it is hatching competent but before it receives the stimulus to hatch. Unlike most organisms, the grunion embryo reaches hatching competence when it is fully developed, once it reaches competence, it stalls development and waits for an environmental cue. Before this, the egg is not hatching competent and will not hatch even if the trigger is there. The fact that it hatches so quickly could be evidence that an enzyme is acting to break down the chorion and this is what I hypothesize causes hatching competence. Some related fish have two chorionases while some only have one. To see whether one or two enzymes act in hatching in the grunion, I made a solution of the hatching enzyme, concentrated it, ran both SDS-PAGE and native-PAGE gels to separate out the protein by size, and cut out and sent those bands away for sequencing. To test whether the egg weakens upon hatching competence, I measured change in diameter of eggs that were pressed under a weight. We found no significant difference in pliability between the two groups of eggs using this methodology. If there are two enzymes, one may be acting before the other. If there is only one enzyme, another mechanism is at play

    Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells

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    The objective of this study was to investigate the impact of cigarette smoke on innate antiviral defense mechanisms; specifically, we examined the effects of cigarette smoke on the induction of type I interferon (IFN). We observed a dose-dependent decrease in the ability of human lung fibroblast and epithelial cells to elicit an antiviral response against a viral double-strand RNA (dsRNA) mimic, polyI:C, in the presence of cigarette smoke-conditioned medium (SCM). Mechanistically, SCM decreases the expression of IFN-stimulated gene 15 (ISG15) and IFN regulatory factor-7 (IRF-7) transcripts and suppresses the nuclear translocation of key transcription factors, nuclear factor-ÎșB (NF-ÎșB) and IRF-3, after polyI:C stimulation. Furthermore, we provide evidence that the intercellular defense strategy against viral infection is also impaired. We observed a decrease in the ability of fibroblasts to elicit an antiviral state in response to IFN-ÎČ stimulation. This was associated with decreased nuclear translocation of phosphorylated Stat1 in response to IFN-ÎČ treatment. The effects elicited by SCM are reversible and are almost entirely abrogated in the presence of an antioxidant, such as glutathione. Our findings suggest that cigarette smoke affects the immediate-early, inductive, and amplification phases of the type I IFN response

    First-Pass Meconium Samples from Healthy Term Vaginally-Delivered Neonates : An Analysis of the Microbiota

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    Acknowledgments The authors would like to thank the parents who consented to provide samples with limited notice at an emotional and stressful time. This work was supported entirely from personal donations to the neonatal endowments fund at Aberdeen Maternity Hospital and we thank families for their continued generosity, year-on-year. The Rowett Institute of Nutrition and Health receives funding from the Scottish Government (SG-RESAS). Funding: This work was funded from NHS Grampian Neonatal Endowments. The Rowett Institute receives funding from the Rural and Environmental Science and Analytical Services programme of the Scottish Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

    Material Model Evaluation of a Composite Honeycomb Energy Absorber

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    A study was conducted to evaluate four different material models in predicting the dynamic crushing response of solid-element-based models of a composite honeycomb energy absorber, designated the Deployable Energy Absorber (DEA). Dynamic crush tests of three DEA components were simulated using the nonlinear, explicit transient dynamic code, LS-DYNA . In addition, a full-scale crash test of an MD-500 helicopter, retrofitted with DEA blocks, was simulated. The four material models used to represent the DEA included: *MAT_CRUSHABLE_FOAM (Mat 63), *MAT_HONEYCOMB (Mat 26), *MAT_SIMPLIFIED_RUBBER/FOAM (Mat 181), and *MAT_TRANSVERSELY_ANISOTROPIC_CRUSHABLE_FOAM (Mat 142). Test-analysis calibration metrics included simple percentage error comparisons of initial peak acceleration, sustained crush stress, and peak compaction acceleration of the DEA components. In addition, the Roadside Safety Verification and Validation Program (RSVVP) was used to assess similarities and differences between the experimental and analytical curves for the full-scale crash test

    Simulating the Response of a Composite Honeycomb Energy Absorber

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    NASA has sponsored research to evaluate an externally deployable composite honeycomb designed to attenuate loads in the event of a helicopter crash. The concept, designated the Deployable Energy Absorber (DEA), is an expandable Kevlar(Registered TradeMark) honeycomb. The DEA has a flexible hinge that allows the honeycomb to be stowed collapsed until needed during an emergency. Evaluation of the DEA began with material characterization of the Kevlar(Registered TradeMark)-129 fabric/epoxy, and ended with a full-scale crash test of a retrofitted MD-500 helicopter. During each evaluation phase, finite element models of the test articles were developed and simulations were performed using the dynamic finite element code, LS-DYNA(Registered TradeMark). The paper will focus on simulations of two full-scale impact tests involving the DEA, a mass-simulator and a full-scale crash of an instrumented MD-500 helicopter. Isotropic (MAT24) and composite (MAT58) material models, which were assigned to DEA shell elements, were compared. Based on simulations results, the MAT58 model showed better agreement with test
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