Design of leather footwear for diabetics containing chlorhexidine digluconate microparticles

2-s2.0-85093852990ChlorHexidine Digluconate [CHD] was encapsulated inside an ethylcellulose shell material [Aquacoat ECD], and then spray dried to produce mixed microparticles (MPs). The validity and functional quality of the resultant [CHD-MPs] were analyzed on vamp and lining leather which are used to manufacture shoes for diabetics. The morphology, efficiency of encapsulation and in vitro release characteristics of the [CHD-MPs] were optimized in order to impregnate [CHD-MPs] onto leather footwear for diabetics. Scanning electron microscopy (SEM) was used to characterize the [CHD-MPs] and the leathers treated with it. SEM images illustrated that the [CHD-MPs] were spherical, smooth in shape and adhered well to leather. In vitro CHD-release studies from its MPs, and for leather treated with it were performed in phosphate buffer saline at pH =7.2. There was an inherently controlled release behaviour of CHD for all the formulations on leather. Finally, microbiologic studies on leather treated with [CHD-MPs] were done. This study suggested that footwear containing [CHD-MPs] is/will improve the quality of daily life for diabetics. © 2020 American Leather Chemists Association. All rights reserved

Encapsulated chlorhexidine digluconate usage on the diabetic footwear upper leathers

34th International Union of Leather Technologists and Chemist Societies Congress, IULTCS 2017 -- 5 February 2017 through 8 February 2017 -- 133186It is important for a therapeutic shoe to have a wearable quality and its comfortable use is also prominent in terms of providing an increase in user's quality of life. In long-term treatment of diseases, medical products which are to be manufactured with medical leather materials might be a prominent alternative via local effect application as an adjuvant to the treatment. It is aimed in this study to produce micro-particles which contain the active agent chlorhexidine digluconate and application of these micro-particles on upper leather for manufacturing diabetic shoes while providing them a functional quality. Within the scope of the project, micro-particles loaded with drugs were obtained via spraying chlorhexidine digluconate active agent and through spraying with ethyl cellulose polymer and ustulation. In vitro characterisation studies were performed on the acquired microparticles. Additionally, active agent quantitation and in vitro drug delivery studies were also performed. Following the studies, the determined optimum microparticle formulations were applied on the leather, then existence and efficiency of microparticles within the leather was shown in the subsequent studies

Effect of vehicles on in vitro release of metronidazole through different membranes

The invitro release tests is a measure of inprocess control and also as a finished product specification for creams, ointments and gels. The objective of this study was to evaluate the in vitro release and ex-vivo percutaneous absorption of Metronidazole (MTD) from different water soluble and oleaginous vehicles. All of the experiments were conducted using three different barriers (synthetic membrane, excised rat and rabbit skins). Within the barriers tested rat skin was found to be the best alternative to the others. Moreover water soluble vehicles could be suggested as good candidates for the topical delivery of MTD, giving higher drug release