Dephasing of Electrons on Helium by Collisions with Gas Atoms

The damping of quantum effects in the transport properties of electrons deposited on a surface of liquid helium is studied. It is found that due to vertical motion of the helium vapour atoms the interference of paths of duration $t$ is damped by a factor $\exp - (t/\tau_v)^3$. An expression is derived for the weak-localization lineshape in the case that damping occurs by a combination of processes with this type of cubic exponential damping and processes with a simple exponential damping factor.Comment: 7 pages, 2 figures, Revte

Antifungal screening and in silico mechanistic studies of an in-house azole library

Systemic Candida infections pose a serious public health problem with high morbidity and mortality. C. albicans is the major pathogen identified in candidiasis, however non-albicans Candida spp. with antifungal resistance are now more prevalent. Azoles are first-choice antifungal drugs for candidiasis, however they are ineffective for certain infections caused by the resistant strains. Azoles block ergosterol synthesis by inhibiting fungal CYP51, which leads to disruption of fungal membrane permeability. In this study, we screened for antifungal activity of an in-house azole library of 65 compounds to identify hit matter followed by a molecular modelling study for their CYP51 inhibition mechanism. Antifungal susceptibility tests against standard Candida spp. including C. albicans revealed derivatives 12 and 13 as highly active. Furthermore, they showed potent antibiofilm activity as well as neglectable cytotoxicity in a mouse fibroblast assay. According to molecular docking studies 12 and 13 have the necessary binding characteristics for effective inhibition of CYP51. Finally, molecular dynamics (MD) simulations of the C. albicans CYP51 (CACYP51) homology model's catalytic site complexed with 13 was stable demonstrating excellent binding. This article is protected by copyright. All rights reserved

Invariance of Charge of Laughlin Quasiparticles

A Quantum Antidot electrometer has been used in the first direct observation of the fractionally quantized electric charge. In this paper we report experiments performed on the integer i = 1, 2 and fractional f = 1/3 quantum Hall plateaus extending over a filling factor range of at least 27%. We find the charge of the Laughlin quasiparticles to be invariantly e/3, with standard deviation of 1.2% and absolute accuracy of 4%, independent of filling, tunneling current, and temperature.Comment: 4 pages, 5 fig

Dephasing Times in a Non-degenerate Two-Dimensional Electron Gas

Studies of weak localization by scattering from vapor atoms for electrons on a liquid helium surface are reported. There are three contributions to the dephasing time. Dephasing by the motion of vapor atoms perpendicular to the surface is studied by varying the holding field to change the characteristic width of the electron layer at the surface. A change in vapor density alters the quasi-elastic scattering length and the dephasing due to the motion of atoms both perpendicular and parallel to the surface. Dephasing due to the electron-electron interaction is dependent on the electron density.Comment: 4 pages, Revte

Magnetoresistance of nondegenerate quantum electron channels formed on the surface of superfluid helium

Transport properties of quasi-one-dimensional nondegenerate quantum wires formed on the surface of liquid helium in the presence of a normal magnetic field are studied using the momentum balance equation method and the memory function formalism. The interaction with both kinds of scatterers available (vapor atoms and capillary wave quanta) is considered. We show that unlike classical wires, quantum nondegenerate channels exhibit strong magnetoresistance which increases with lowering the temperature.Comment: 8 pages, 7 figure

Microstructural, Biomechanical, and In Vitro Studies of Ti-Nb-Zr Alloys Fabricated by Powder Metallurgy

Data Availability Statement: The data underpinning this publication can be accessed from Brunel University London’s data repository, Brunelfigshare here under a CCBY licence: https://doi.org/10.17633/rd.brunel.5446813.v1. Non-digital data supporting this study are stored by the corresponding author at Brunel University. Details of how to request access to these data are provided here: https://doi.org/10.17633/rd.brunel.5446813.v1.Supplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/ma16124240/s1, Figure S1: Plasmid–DNA interaction assay for Ti-Nb-Zr based alloys. The migration pattern of plasmid DNA incubated with Ti-Nb-Zr-based alloys and TiRG4 reference materials is shown in the figure. The bands are labeled as NC: Nicked circular and SC: Supercoiled; ddH2O served as a negative control.Copyright © 2023 by the authors. This study investigated the microstructures, mechanical performances, corrosion resistances, and in vitro studies of porous Ti-xNb-10Zr (x: 10 and 20; at. %) alloys. The alloys were fabricated by powder metallurgy with two categories of porosities, i.e., 21–25% and 50–56%, respectively. The space holder technique was employed to generate the high porosities. Microstructural analysis was performed by using various methods including scanning electron microscopy, energy dispersive spectroscopy, electron backscatter diffraction, and x-ray diffraction. Corrosion resistance was assessed via electrochemical polarisation tests, while mechanical behavior was determined by uniaxial compressive tests. In vitro studies, such as cell viability and proliferation, adhesion potential, and genotoxicity, were examined by performing an MTT assay, fibronectin adsorption, and plasmid-DNA interaction assay. Experimental results showed that the alloys had a dual-phase microstructure composed of finely dispersed acicular hcp α-Ti needles in the bcc β-Ti matrix. The ultimate compressive strength ranged from 1019 MPa to 767 MPa for alloys with 21–25% porosities and from 173 MPa to 78 MPa for alloys with 50–56% porosities. Noted that adding a space holder agent played a more critical role in the mechanical behaviors of the alloys compared to adding niobium. The pores were largely open and exhibited irregular shapes, with uniform size distribution, allowing for cell ingrowth. Histological analysis showed that the alloys studied met the biocompatibility criteria required for orthopaedic biomaterial use.EPSRC Future LiME Hub (EP/N007638/1); PhD studentship, the Republic of Turkey Ministry of National Education

Resistance fluctuations and Aharonov-Bohm-type oscillations in antidot arrays in the quantum Hall regime

Resistance fluctuation phenomenon in antidot lattices in the quantum Hall regime are studied. Magnetoresistance of finite antidot array systems in the quantum Hall plateau transition regime exhibits two types of oscillatory effect. One is the aperiodic resistance fluctuations (RFs) and the other is the Aharonov-Bohm (AB)-type oscillations. Their dependences on the magnetic field and the gate voltage are quite distinct. While the aperiodic RFs are attributed to the complex evolution of the conducting network of compressible channels, the AB-type oscillations are interpreted in terms of edge states formed around individual antidots. The self-consistent screening effect is important for the both phenomenon, whereas, the single electron charging effect plays a minor role in the present case.Comment: 5 pages, 4 figure