High Purity Electrolytic Manganese From Low-Grade Ore as a Substitute for Various Forms of Manganese Now being used in Metallurgical Industries

India produces about 1 million tons of high-grade manganese ores every year and about the same quantity of low-grade ores is being dumped in the mining areas. Besides high-grade ores she has abundant resources of low-grade ores for which there is practically no market. Investigations have already been undertaken in this country under the Five Year Plan to utilize these low-grade ores by different methods of beneficiation and also by the production of high purity electrolytic manganese. The purpose of this article is to discuss in the light of the experiments carried out in U.S.A. that high purity electrolytic manganese from low-grade ores can be substituted for different forms of manganese specially ferro-manganese now being employed in metallurgical industries. The main disadvantage in using electrolytic manganese is its comparatively high cost of production. A substantial reduction in the price can be expected if the demand for electrolytic manganese increases with increasing use. The present price of electrolytic manganese is 31 cents per pound. It has been estimated by the U.S. Bureau of Mines that in a 40 ton per day electrolytic manganese plant, the total operating cost, exclusive of taxes, interest, ore, sales and plant insurance, comes to about 7-2 cents per pound

The application of electrolytic manganese as a substitute ferro alloy

INDIA has got vast deposits of high grade and I low grade manganese ores which are among the most important minerals of the country. High grade ores, which are mined anuually to the extent of more than a million tons , are generally exported or utilised for the production of standard grade ferromanganese. Investigations have been undertaken in N.M.L. and other places in India to upgrade these low grade manganese ores by different methods of beneficiation' and to utilise them for producing standard grade ferromanganese. National Metallurgical Laboratory has also developed a method to produce electrolytic mang-anese from low grade ores.2 4 Electromanganese is now being produced at the rate of 50 kg per day in one cell in the pilot plant set up in the laboratory. This manganese is being utilised for producing nickel-free stainless steel which has already been developed in N.M.L. and also for other experimental purposes, in addition to a portion of the same being supplied to defence and other industries

Geometry of deformations of branes in warped backgrounds

The `braneworld' (described by the usual worldvolume action) is a D dimensional timelike surface embedded in a N dimensional ($N>D$) warped, nonfactorisable spacetime. We first address the conditions on the warp factor required to have an extremal flat brane in a five dimensional background. Subsequently, we deal with normal deformations of such extremal branes. The ensuing Jacobi equations are analysed to obtain the stability condition. It turns out that to have a stable brane, the warp factor should have a minimum at the location of the brane in the given background spacetime. To illustrate our results we explicitly check the extremality and stability criteria for a few known co-dimension one braneworld models. Generalisations of the above formalism for the cases of (i) curved branes (ii) asymmetrical warping and (iii) higher co-dimension braneworlds are then presented alongwith some typical examples for each. Finally, we summarize our results and provide perspectives for future work along these lines.Comment: 21 pages. Version matching final version. Accepted for publication in Class. Quant. Gra

Transverse nucleon structure and diagnostics of hard parton-parton processes at LHC

We propose a new method to determine at what transverse momenta particle production in high-energy pp collisions is governed by hard parton-parton processes. Using information on the transverse spatial distribution of partons obtained from hard exclusive processes in ep/gamma p scattering, we evaluate the impact parameter distribution of pp collisions with a hard parton-parton process as a function of p_T of the produced parton (jet). We find that the average pp impact parameters in such events depend very weakly on p_T in the range 2 < p_T < few 100 GeV, while they are much smaller than those in minimum-bias inelastic collisions. The impact parameters in turn govern the observable transverse multiplicity in such events (in the direction perpendicular to the trigger particle or jet). Measuring the transverse multiplicity as a function of p_T thus provides an effective tool for determining the minimum p_T for which a given trigger particle originates from a hard parton-parton process. Additional tests of the proposed geometric correlations are possible by measuring the dependence on the trigger rapidity. Various strategies for implementing this method are outlined.Comment: 9 pages, 6 figure

Environmental and Waste Management in Some Mining Operations in Orissa

This paper attempts to provide a survey on environmental parameters, viz. solids and liquids collected from five different mines in Orissa. These mines are (i) Dolomite Quarry, or Gomardih (Tisco) (ii) Fireclay Mines, Talabasta (Grind)(iii) Iron Ore Mines, Joribahal (Patnaik Minerals Pvt.Ltd.) (iv) Limestone Quarry,Lanjiherna (O CL) and (v) Graphite Mines, Patnagarh (T. Pradhan). The solid samples consisted of (a) top more often the undisturbed soil near the mine, (b) the overburdenlwastelspoilt dump, (c) soil from nearby paddyfield, (d) plantation area and (e) garden. These are analysed for agricultural parameters .such aspll, organic carbon content, available phosphate and potassium, heavy metals such as copper, lead, zinc, chromium etc. and bacterial count. The liquid sample consisted of water and effluent collected from (i) mine pit/flow both active and abandoned, (ii) mine discharge, (iii) mineral spring, (iv) accumulated water in mines, (v) piped water in mine office and residential colony and (vi) dug well used by mine workers. These samples were analysed for heavy metals similar to solid samples, physical parameters such as total suspended solids (TSS), total dissolved solids (TDS) and the bacterial count. The analysed results were compared with the standards set by the Bureau of Indian Standards (BIS) and Central Pollution Control Board (CPCB) and recommendations on pollution control measures and strategy by other means are made for better environmental management

Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca 2+ Signals

© 2016 The Author(s) Excitation-transcription coupling, linking stimulation at the cell surface to changes in nuclear gene expression, is conserved throughout eukaryotes. How closely related coexpressed transcription factors are differentially activated remains unclear. Here, we show that two Ca2+-dependent transcription factor isoforms, NFAT1 and NFAT4, require distinct sub-cellular InsP3 and Ca2+ signals for physiologically sustained activation. NFAT1 is stimulated by sub-plasmalemmal Ca2+ microdomains, whereas NFAT4 additionally requires Ca2+ mobilization from the inner nuclear envelope by nuclear InsP3 receptors. NFAT1 is rephosphorylated (deactivated) more slowly than NFAT4 in both cytoplasm and nucleus, enabling a more prolonged activation phase. Oscillations in cytoplasmic Ca2+, long considered the physiological form of Ca2+ signaling, play no role in activating either NFAT protein. Instead, effective sustained physiological activation of NFAT4 is tightly linked to oscillations in nuclear Ca2+. Our results show how gene expression can be controlled by coincident yet geographically distinct Ca2+ signals, generated by a freely diffusible InsP3 message

Embedding Recovery to Transform Inpatient Mental Health Care: The 333 Model

Objective: The 333 model is a radical redesign of acute mental health care. Time-limited inpatient pathways for assessment (≤3 days), treatment (≤3 weeks), and recovery (≤3 months) replaced traditional geographical-sector wards. By making beds available, 333 aspired to improve access, deliver early treatment, and shorten hospital stays—generating savings through reductions in beds and out-of-area placements (OAPs). This article compares the model’s performance against national benchmarking and internal targets. Methods: The complement of general adult beds (2011–2016) was mapped out. Patient flow data (April 2015–March 2017) were extracted from the National Health Service data warehouse and compared with 2016 NHS benchmarking and 333 targets. Results: Between 2012 and 2016, beds were reduced by 44% compared with 17% nationally. OAPs due to bed unavailability became extremely rare. More than 74% (N=2,679) of patients who were admitted to the assessment unit between 2015 and 2017 were discharged back to the community, minimizing fragmentation of care. Median length of stay was one-sixth as long as the national rate, but readmission rates were higher than the national mean because of the model’s innovative approach to managing treatment of patients with personality disorders. Bed occupancy was below the national average, with beds available every night for 2 years. Conclusions: With its recovery-focused approach, 333 has reduced length of stay and ensured that a stay on any ward is meaningful and adds value. The article demonstrates that bed and OAP reduction and the delivery of safe care can be achieved simultaneously

Evolving wormhole geometries

We present here analytical solutions of General Relativity that describe evolving wormholes with a non-constant redshift function. We show that the matter that threads these wormholes is not necessarily exotic. Finally, we investigate some issues concerning WEC violation and human traversability in these time-dependent geometries.Comment: 12 pages latex, 3 figures, to appear in Phys. Rev. D., Title correcte

Differences in level of confidence in diabetes care between different groups of trainees: the TOPDOC diabetes study

Background There is an increasing prevalence of diabetes. Doctors in training, irrespective of specialty, will have patients with diabetes under their care. The aim of this further evaluation of the TOPDOC Diabetes Study data was to identify if there was any variation in confidence in managing diabetes depending on the geographical location of trainees and career aspirations. Methods An online national survey using a pre-validated questionnaire was administered to trainee doctors. A 4-point confidence rating scale was used to rate confidence in managing aspects of diabetes care and a 6-point scale used to quantify how often trainees would contribute to the management of patients with diabetes. Responses were grouped depending on which UK country trainees were based and their intended career choice. Results Trainees in Northern Ireland reported being less confident in IGT diagnosis, use of IV insulin and peri-operative management and were less likely to adjust oral treatment, contact specialist, educate lifestyle, and optimise treatment. Trainees in Scotland were less likely to contact a specialist, but more likely to educate on lifestyle, change insulin, and offer follow-up advice. In Northern Ireland, Undergraduate (UG) and Postgraduate (PG) training in diagnosis was felt less adequate, PG training in emergencies less adequate, and reporting of need for further training higher. Trainees in Wales felt UG training to be inadequate. In Scotland more trainees felt UG training in diagnosis and optimising treatment was inadequate. Physicians were more likely to report confidence in managing patients with diabetes and to engage in different aspects of diabetes care. Aspiring physicians were less likely to feel the need for more training in diabetes care; however a clear majority still felt they needed more training in all aspects of care. Conclusions Doctors in training have poor confidence levels dealing with diabetes related care issues. Although there is variability between different groups of trainees according to geographical location and career aspirations, this is a UK wide issue. There should be a UK wide standardised approach to improving training for junior doctors in diabetes care with local training guided by specific needs.</p

SnTox3 Acts in Effector Triggered Susceptibility to Induce Disease on Wheat Carrying the Snn3 Gene

The necrotrophic fungus Stagonospora nodorum produces multiple proteinaceous host-selective toxins (HSTs) which act in effector triggered susceptibility. Here, we report the molecular cloning and functional characterization of the SnTox3-encoding gene, designated SnTox3, as well as the initial characterization of the SnTox3 protein. SnTox3 is a 693 bp intron-free gene with little obvious homology to other known genes. The predicted immature SnTox3 protein is 25.8 kDa in size. A 20 amino acid signal sequence as well as a possible pro sequence are predicted. Six cysteine residues are predicted to form disulfide bonds and are shown to be important for SnTox3 activity. Using heterologous expression in Pichia pastoris and transformation into an avirulent S. nodorum isolate, we show that SnTox3 encodes the SnTox3 protein and that SnTox3 interacts with the wheat susceptibility gene Snn3. In addition, the avirulent S. nodorum isolate transformed with SnTox3 was virulent on host lines expressing the Snn3 gene. SnTox3-disrupted mutants were deficient in the production of SnTox3 and avirulent on the Snn3 differential wheat line BG220. An analysis of genetic diversity revealed that SnTox3 is present in 60.1% of a worldwide collection of 923 isolates and occurs as eleven nucleotide haplotypes resulting in four amino acid haplotypes. The cloning of SnTox3 provides a fundamental tool for the investigation of the S. nodorum-wheat interaction, as well as vital information for the general characterization of necrotroph-plant interactions.This work was supported by USDA-ARS CRIS projects 5442-22000-043-00D and 5442-22000-030-00D