14 research outputs found
Echocardiographic Parameters in Athlete and Nonathlete Offspring of Hypertensive Parents
Association of Uric Acid with Obesity and Endothelial Dysfunction in Children and Early Adolescents
Race/ethnicity determines the relationships between oxidative stress markers and blood pressure in individuals with high cardiovascular disease risk
Early carotid atherosclerosis and cardiac diastolic abnormalities in hypertensive subjects
Common carotid arterial interadventitial distance (diameter) as an indicator of the damaging effects of age and atherosclerosis, a cross-sectional study of the Atherosclerosis Risk in Community Cohort Limited Access Data (ARICLAD), 1987–89
Urinary norepinephrine and epinephrine excretion rates are heritable, but not associated with office and ambulatory blood pressure
Genetic and environmental contributions to urinary excretion rates of norepinephrine (UNEV) and epinephrine (UEV) and their association with blood pressure (BP) were investigated in 91 African American (mean age, 17.3 +/- 2.6 years) and 101 European American (mean age, 18.7 +/- 3.4 years) mono- and di-zygotic twins. Genetic modeling was performed using Mx software. UNEV (1.9 +/- 1.3 mu g h(-1)) and UEV (0.2 +/- 0.2 mu g h(-1)) were highly correlated (r = 0.81, P < 0.001). Significant heritabilities for UNEV (0.68) and UEV (0.74) without ethnic and gender effects were observed. The genetic correlation between UNEV and UEV was 0.86. There was no clear pattern of correlations for UNEV and UEV with BP measures in European Americans, but African Americans showed some inverse correlations of moderate size. Measurements of UNEV and UEV provide a viable method for the study of sympathetic tone and are substantially heritable. Hypertension Research (2012) 35, 1164-1170; doi:10.1038/hr.2012.104; published online 12 July 2012