Role of two tumor markers CYFRA 21-1 (Cytokeratin Fragment 21) and CEA (Carcinoembryonic Antigen) in Lung Carcinoma.

Objectives: To find out 1) the role of CYFRA 21-1 in diagnosis of lung cancer; 2) the sensitivity and specificity of CYFRA 21-1 and CEA levels in lung carcinoma; and 3) levels of CYFRA 21-1 after treatment of lung cancer. Study Design: Hospital based cross-sectional study. Methods: A total of 78 patients were taken including 58 cases and 20 controls. Patients with lung carcinoma with proper staging were included in the study. CEA was measured using UBI MAGIWELL CEA CM-201 kit and CYFRA 21-1 was measured using ECLIA kit manufactured by Roche diagnostics USA. The statistical analysis was done using t-test, ANOVA and post hoc analysis. Results: Using a threshold value of 3.0 ng/ml for CYFRA 21-1, sensitivity and specificity, were 90.1% and 90.0% respectively whereas for CEA with threshold value of 3.0 ng/ml for non smokers and 5.0 ng/ml for smokers, sensitivity and specificity were 44.9% and 75.0% respectively. The sensitivity of tumor markers for squamous cell, adenocarcinoma and small cell carcinoma was 96%, 80% and 70.4% respectively for CYFRA 21-1 and for CEA it was 48.3%, 60% and 52.1% respectively. Conclusions: CYFRA 21-1 is a sensitive and specific marker for lung carcinoma. CEA can be used as a tumor marker in lung carcinoma but it is inferior to CYFRA 21-1 in diagnosing lung carcinoma especially squamous cell type

Book of Abstracts of the 2nd International Conference on Applied Mathematics and Computational Sciences (ICAMCS-2022)

It is a great privilege for us to present the abstract book of ICAMCS-2022 to the authors and the delegates of the event. We hope that you will find it useful, valuable, aspiring, and inspiring. This book is a record of abstracts of the keynote talks, invited talks, and papers presented by the participants, which indicates the progress and state of development in research at the time of writing the research article. It is an invaluable asset to all researchers. The book provides a permanent record of this asset. Conference Title: 2nd International Conference on Applied Mathematics and Computational SciencesConference Acronym: ICAMCS-2022Conference Date: 12-14 October 2022Conference Organizers: DIT University, Dehradun, IndiaConference Mode: Online (Virtual