Web Services for forward integration in international tourism supply chains: A case study of tourism in Thailand

International tourism is a highly competitive and information-intensive industry. Customers need volumes of information for decision aids. Moreover, the decision-making processes are quite sensitive to the variables of personal preferences, the tourist industrial ecosystem, the legal regulations and political environments of destinations, the regional or global economic situations, the natural matters, and so on. Hence, the owners of tourism are motivated to upgrade the competitiveness of their businesses with information technologies. This paper intends to design the architecture of Web Services in international tourism, which can contribute to the forward integration in international tourism supply chains. First, the authors conduct an in-depth case study of a regional tour operator in Thailand. In the case study, we examine the strength, weakness, challenges visions, and strategic approaches of international tourism, and their relationships with the information systems in the tourist business. Then, this paper designs the architecture of Web Services in international tourism. The architecture is expected to improve the information transparency through the global tourism supply chain, construct business-to-business collaboration mechanism, provide efficient and effective information to tourists, and consequently contribute to forward integration in international tourism supply chains

Classification of Hospital Web Security Efficiency Using Data Envelopment Analysis and Support Vector Machine

This study proposes the hybrid data envelopment analysis (DEA) and support vector machine (SVM) approaches for efficiency estimation and classification in web security. In the proposed framework, the factors and efficiency scores from DEA models are integrated with SVM for learning patterns of web security performance and provide further decision support. The numerical case study of hospital web security efficiency is demonstrated to support the feasibility of this design

α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding.

Invariant natural killer T (iNKT) cells, which are activated by T cell receptor (TCR)-dependent recognition of lipid-based antigens presented by the CD1d molecule, have been shown to participate in the pathogenesis of many diseases, including asthma and liver injury. Previous studies have shown the inhibition of iNKT cell activation using lipid antagonists can attenuate iNKT cell-induced disease pathogenesis. Hence, the development of iNKT cell-targeted glycolipids can facilitate the discovery of new therapeutics. In this study, we synthesized and evaluated α-lactosylceramide (α-LacCer), an α-galactosylceramide (α-GalCer) analog with lactose substitution for the galactose head and a shortened acyl chain in the ceramide tail, toward iNKT cell activation. We demonstrated that α-LacCer was a weak inducer for both mouse and human iNKT cell activation and cytokine production, and the iNKT induction by α-LacCer was CD1d-dependent. However, when co-administered with α-GalCer, α-LacCer inhibited α-GalCer-induced IL-4 and IFN-γ production from iNKT cells. Consequently, α-LacCer also ameliorated both α-GalCer and GSL-1-induced airway hyperreactivity and α-GalCer-induced neutrophilia when co-administered in vivo. Furthermore, we were able to inhibit the increases of ConA-induced AST, ALT and IFN-γ serum levels through α-LacCer pre-treatment, suggesting α-LacCer could protect against ConA-induced liver injury. Mechanistically, we discerned that α-LacCer suppressed α-GalCer-stimulated cytokine production through competing for CD1d binding. Since iNKT cells play a critical role in the development of AHR and liver injury, the inhibition of iNKT cell activation by α-LacCer present a possible new approach in treating iNKT cell-mediated diseases

Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils

Inverse Melting of an Electronic Liquid Crystal

Inverse melting refers to the rare thermodynamic phenomenon in which a solid melts into a liquid upon cooling, a transition that can occur only when the ordered (solid) phase has more entropy than the disordered (liquid) phase, and that has so far only been observed in a handful of systems. Here we report the first experimental observation for the inverse melting of an electronic liquid crystalline order in strontium-doped lanthanum nickelate, a compound isostructural with the superconducting cuprates, with a hole doping concentration of 1/3. Using x-ray scattering, we demonstrate that the isotropic charge modulation is driven to nematic order by fluctuating spins and shows an inverse melting transition. Using a phenomenological Landau theory, we show that this inverse melting transition is due to the interlayer coupling between the charge and spin orders. This discovery points to the importance of the interlayer correlations in the system, and provides a new perspective to study the intricate nature of the electronic liquid crystal phases in strongly correlated electronic systems, including possibly the Cu- and Fe-based high-Tc superconductors.Comment: 7 pages, 7 figure

Inverse order-disorder transition of charge stripes

We report an unusual transition behavior of charge stripes in La1.67Sr0.33NiO4 using x-ray scattering. The segregated holes in La1.67Sr0.33NiO4 are observed to form anisotropic stripes in the a × b plane of the crystal space below the transition temperature T 238 K, and at the same time, display an unusual inverse order-disorder transition along the c axis. Using a phenomenological Landau theory, we show that this inverse transition is due to the interlayer coupling between the charge and spin orders. This discovery points to the importance of the interlayer correlations in the strongly correlated electrons system