202 research outputs found
Detection of Novel Enterovirus with Emergency Department Based Syndromic Surveillance System in Taipei City
Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells
A set of 10 4,7-dimethoxy-1,3-benzodioxole derivatives based on a lead compound previously discovered by our group, SY-1, which was isolated from Antrodia camphorata, were evaluated for their in vitro inhibitory activity on human colorectal carcinoma cells (COLO 205). Structure-activity relationship studies of the 10 compounds indicated the importance of the chain length of the alkyl group at the 5-position, and the 2-propenyl substituent named “apiole” exhibited the most potent inhibitory activity. In the present study, we demonstrate that the SY-1 analogue “apiole” decreased the proliferation of COLO 205 cells, but not that of normal human colonic epithelial cells (FHC). The G0/G1 cell cycle arrest induced by apiole (75–225 μM) was associated with significantly increased levels of p53, p21 and p27 and decreased levels of cyclin D1. Concerning COLO 205 cell apoptosis, apiole (>150 μM) treatment significantly increased the levels of cleaved caspases 3, 8, 9 and bax/bcl-2 ratio and induced ladder formation in DNA fragmentation assay and sub-G1 peak in flow cytometry analysis. These findings suggest that apiole can suppress COLO 205 cell growth; however, the detailed mechanisms of these processes require further investigation
Bulk Versus Edge in the Quantum Hall Effect
The manifestation of the bulk quantum Hall effect on edge is the chiral
anomaly. The chiral anomaly {\it is} the underlying principle of the ``edge
approach'' of quantum Hall effect. In that approach, \sxy should not be taken
as the conductance derived from the space-local current-current correlation
function of the pure one-dimensional edge problem.Comment: 4 pages, RevTex, 1 postscript figur
The Origin of the White Roman Goose
In order to avoid interference from nuclear copies of mitochondrial DNA (numts), mtDNA of the white Roman goose (domestic goose) was extracted from liver mitochondria. The mtDNA control region was amplified using a long PCR strategy and then sequenced. Neighbor-joining, maximum parsimony, and maximum-likelihood approaches were implemented using the 1,177 bp mtDNA control region sequences to compute the phylogenetic relationships of the domestic goose with other geese. The resulting identity values for the white Roman geese were 99.1% (1,166/1,177) with western graylag geese and 98.8% (1,163/1,177) with eastern graylag geese. In molecular phylogenetic trees, the white Roman goose was grouped in the graylag lineage, indicating that the white Roman goose came from the graylag goose (Anser anser). Thus, the scientific name of the white Roman goose should be Anser anser 'White Roman.'
Acute anal stretch inhibits NMDA-dependent pelvic-urethra reflex potentiation via spinal GABAergic inhibition in anesthetized rats
The impact of acute anal stretch on the pelvic-urethra reflex potentiation was examined in urethane-anesthetized rats by recording the external urethra sphincter electromyogram activity evoked by the pelvic afferent stimulation. Test stimulation (1 stimulation/30 s) evoked a baseline reflex activity with a single action potential that was abolished by gallamine (5 mg/kg iv). On the other hand, the repetitive stimulation (1 stimulation/1 s) induced spinal reflex potentiation (SRP) that was attenuated by intrathecal 6-cyano-7-nitroquinoxaline- 2,4-dione (a glutamatergic alpha-amino-3-hydroxy-5-methyl- 4-isoxazoleproprionat receptor antagonist, 100 mu M, 10 mu l) and D-2-amino-5-phosphonovalerate [a glutamatergic N-methyl-D-aspartate (NMDA) antagonist, 100 mu M, 10 mu l]. Acute anal stretch using a mosquito clamp with a distance of 4 mm exhibited no effect, whereas distances of 8 mm attenuated and 12 mm abolished the repetitive stimulation-induced SRP. Intrathecal NMDA (100 mu M, 10 mu l) reversed the abolition on SRP caused by anal stretch. On the other hand, pretreated bicuculline [gamma-aminobutyric acid (GABA) A receptor antagonist, 100 mu M, 10 mu l] but not hydroxysaclofen (GABA(B) receptor antagonist) counteracted the abolition on the repetitive stimulation-induced SRP caused by the anal stretch. All of the results suggested that anal stretch may be used as an adjunct to assist voiding dysfunction in patients with overactive urethra sphincter and that GABAergic neurotransmission is important in the neural mechanisms underlying external urethra sphincter activity inhibited by anal stretch
Power-law entropy-corrected HDE and NADE in Brans-Dicke cosmology
Considering the power-law corrections to the black hole entropy, which appear
in dealing with the entanglement of quantum fields inside and outside the
horizon, the holographic energy density is modified accordingly. In this paper
we study the power-law entropy-corrected holographic dark energy in the
framework of Brans-Dicke theory. We investigate the cosmological implications
of this model in detail. We also perform the study for the new agegraphic dark
energy model and calculate some relevant cosmological parameters and their
evolution. {As a result we find that this model can provide the present cosmic
acceleration and even the equation of state parameter of this model can cross
the phantom line provided the model parameters are chosen suitably}.Comment: 14 pages, 2 figure, accepted by IJT
Holographic dark energy with time varying parameter
We consider the holographic dark energy model in which the model parameter
evolves slowly with time. First we calculate the evolution of EoS
parameter as well as the deceleration parameter in this generalized version of
holographic dark energy (GHDE). Depending on the parameter , the phantom
regime can be achieved earlier or later compare with original version of
holographic dark energy. The evolution of energy density of GHDE model is
investigated in terms of parameter . We also show that the time-dependency
of can effect on the transition epoch from decelerated phase to
accelerated expansion. Finally, we perform the statefinder diagnostic for GHDE
model and show that the evolutionary trajectories of the model in plane
are strongly depend on the parameter .Comment: 16 pages, 4 figures, accepted by Astrophys Space Sc
Interacting Ricci Dark Energy with Logarithmic Correction
Motivated by the holographic principle, it has been suggested that the dark
energy density may be inversely proportional to the area of the event
horizon of the universe. However, such a model would have a causality problem.
In this work, we consider the entropy-corrected version of the holographic dark
energy model in the non-flat FRW universe and we propose to replace the future
event horizon area with the inverse of the Ricci scalar curvature. We obtain
the equation of state (EoS) parameter , the deceleration
parameter and in the presence of interaction between Dark
Energy (DE) and Dark Matter (DM). Moreover, we reconstruct the potential and
the dynamics of the tachyon, K-essence, dilaton and quintessence scalar field
models according to the evolutionary behavior of the interacting
entropy-corrected holographic dark energy model.Comment: 24 pages, accepted for publication in 'Astrophysics and Space
Science, DOI:10.1007/s10509-012-1031-8
Cosmological evolution and statefinder diagnostic for new holographic dark energy model in non flat universe
In this paper, the holographic dark energy model with new infrared cut-off
proposed by Granda and Oliveros has been investigated in spatially non flat
universe. The dependency of the evolution of equation of state, deceleration
parameter and cosmological evolution of Hubble parameter on the parameters of
new HDE model are calculated. Also, the statefinder parameters and in
this model are derived and the evolutionary trajectories in plane are
plotted. We show that the evolutionary trajectories are dependent on the model
parameters of new HDE model. Eventually, in the light of SNe+BAO+OHD+CMB
observational data, we plot the evolutionary trajectories in and
planes for best fit values of the parameters of new HDE model.Comment: 11 pages, 5 figures, Accepted by Astrophys. Space Sc
Large-scale magnetic fields from inflation due to a -even Chern-Simons-like term with Kalb-Ramond and scalar fields
We investigate the generation of large-scale magnetic fields due to the
breaking of the conformal invariance in the electromagnetic field through the
-even dimension-six Chern-Simons-like effective interaction with a fermion
current by taking account of the dynamical Kalb-Ramond and scalar fields in
inflationary cosmology. It is explicitly demonstrated that the magnetic fields
on 1Mpc scale with the field strength of G at the present time
can be induced.Comment: 18 pages, 6 figures, version accepted for publication in Eur. Phys.
J.
- …