Molecular Classification of Diffuse Gliomas

In 2016 WHO classification of CNS tumors genotypic and phenotypic parameters were integrated to define a new nomenclature of diffuse gliomas on the basis of presence or absence of isocitrate dehydrogenase mutations. This resulted in more homogenous and narrowly defined categories with better accuracy of prognostic information, thus, playing a crucial role in patient management. Broadly, astrocytomas are now histologically and genetically distinct with IDH-mutant, ATRX-mutant, 1p/19q-intact and oligodendroglial tumors has IDH-mutant, ATRX-wildtype and 1p/19q-codeleted profile. Glioblastoma are now classified into primary and secondary on the basis of IDH mutations independent of clinical history

Analysis of impact of complete dentures on respiratory performance: An observational study

Background: The present study was conducted for analysing the impact of Complete Dentures on Respiratory Performance. Materials & methods: 20 subjects with presence complete edentulous arch and who had history of complete denture usage for atleast five years were enrolled. Spirometric testing was carried out at following steps: Phase 1: Testing in absence of denture, Phase 2: Testing in presence of both dentures, Phase 3: Testing in presence of maxillary denture only; and Phase 4: Testing in presence of mandibular dentures only. FVC value, PEF value, FEV1 value and FEF25–75 value was recorded with the spirometric test. Analysis of all the results was done by SPSS software, followed by assessment of level of significant with chi-square test and student test. Results: While analysing statistically, it was seen that there was significant decrease in value of Spirometric variables in the presence of dentures. Conclusion: Denture wearer edentulous patients are subjected to risk of development of Spirometric alterations. Hence; these patients should be given timely instructions about various respiratory exercise protocols

Assessment of implant failure rate in smokers and non-smokers

Background: One of the most imperative developments in modern dentistry is the ability to replace missing teeth using titanium implants placed directly into the jaw. Smoking has been associated with countless diseases, including cancer and neurological, cardiovascular, and respiratory diseases. Hence; the present study was conducted for assessing the implant failure rate in smokers and non-smokers. Materials & methods: A total of 100 subjects were enrolled in the present study. All the 100 subjects were divided into four study groups according to their cigarette smoking habits as follows: Group A: 25 non-smokers, Group B: 25 smokers with habit of smoking less than 5 cigarettes per day from past 5 years, Group C: 25 smokers with habit of smoking 5 to 10 cigarettes per day from past 5 years, and Group D: 25 smokers with habit of smoking more than 10 cigarettes per day from past 5 years. Radiographic and assessment of all the patients was done at six months follow-up. Results: Success rate of dental implant therapy among subjects of group A, group B, group C and group D was 100 percent, 92 percent, 84 percent and 76 percent respectively

Homocysteine levels in implant failure patients: an observational study

Background: Dental implants have been a part of our lives since 1965 when studies of Branemark commenced. Today, ever increasing number of dental implants in total or partial edentulous patients provides an outstanding treatment alternative to conventional prosthetic rehabilitation all around the world. However, widespread use of dental implants has brought alone a gradually increasing condition called “disease of peri-implant tissues”. The present study was conducted for assessing the Homocysteine levels in implant failure patients. Materials & methods: A total of 25 subjects with clinical and radiographic evidence of peri-implantitis and 25 healthy controls were enrolled. Complete demographic and clinical details of all the subjects were obtained. Fasting (minimum of 12hrs) venous blood samples were collected. The venous blood was collected in plain vials which will sent to the laboratory for biochemical analysis and evaluation of systemic parameters of both peri-implantitis group and control group. Serum homocysteine was assessed by means of Elisa Immunoassay. Results: Mean serum homocysteine levels among subjects of the control group and peri-implantitis group was 13.27 µmol/L and 25.2 µmol/L respectively. Significant results were obtained while comparing the mean serum homocysteine levels among subjects of the peri-implantitis group and control group

Evaluation of flexural strength of glass carbomer cement and conventional glass ionomer cement: A comparative study

Background: The conventional glass ionomer cement (GIC) has been advocated as a restorative material because of its ability to chemically bond to tooth structures and release fluoride.Recently, glass carbomer cement, a GIC-based restorative material, has been introduced with claims of improved physical characteristics. Hence; the present study was conducted for comparing the Flexural Strength of Glass Carbomer Cement and Conventional Glass Ionomer Cement.Materials & methods: The present study was conducted for comparing the Flexural Strength of Glass Carbomer Cement and Conventional Glass Ionomer Cement. Study moulds were made out of silicone putty material. Stainless steel scaffolding was used for creating a mould of desired dimensions.  Total 40 specimens were prepared and divided into two study groups with 20 specimens in each group. One group was of conventional GIC while the other group was GCC.After preparation of the specimen, testing of flexural strength was done using universal force testing machine. All the results were recorded, analysed and compared. Results: Mean flexural strength of GIC and GCC was 28.3 MPa and 26.9 MPa respectively. Non-significant results were obtained while comparing the mean flexural strength of GIC and GCC. Conclusion: Flexural strength of glass carbomer cement was similar to conventional glass ionomer cement.&nbsp

IMPLEMENTATION AND COMPARISION OF DATA LINK QUALITY SCHEME ON ODMRP AND ADMR IN MANETs

ABSTRACT An ad hoc network is a collection of wireless mobile nodes dynamically forming a temporary network without the use of any fixed network infrastructure or centralized administration. In order to enable communication within the network, a routing protocol is needed to discover routes between nodes. The primary goal of ad hoc network routing protocols is to establish routes between node pairs so that messages may be delivered reliably and in a timely manner. The objective of any routing protocol is to have packet delivered with least possible cost in terms o

Analysis of serum metal ion levels in dental implant patients

Background: Dental implants have been widely used for the replacement of missing teeth in fully and partially edentulous patients. Titanium (Ti) has been the material of choice for dental implants due to its superior corrosion resistance behaviour and desirable mechanical properties. Hence; the present study was undertaken for assessing the serum metal ion levels in Dental Implant Patients. Materials & methods: A total of 20 subjects with missing mandibular first molar and scheduled for prosthetic rehabilitation for same using dental implant therapy were enrolled. Blood samples were obtained at baseline and sent to laboratory where auto-analyser was used for evaluation of metal ions levels. All the dental implant procedures were carried out under the hands of skilled implantologists. After placement of dental implants, blood samples were obtained at 8 weeks and 6 months follow-up. Metal ions were assessed at subsequent follow-ups. All the results were analysed by SPSS software. Results: Mean serum titanium concentration at baseline, 8 weeks and 6 months was fond to be 2.39 mg/dL, 2.35 mg/dL and 2.38 mg/dL respectively. Mean serum aluminium concentration at baseline, 8 weeks and 6 months was fond to be 4.19 mg/dL, 4.16 mg/dL and 4.18 mg/dL respectively

Assessment of impact of relief at the median palatal plate on denture-supporting ability

Background: The present study was conducted for assessing the impact of relief at the Median Palatal Plate on Denture-supporting Ability. Materials & methods: The present study was conducted for assessing the impact of relief at the Median Palatal Plate on Denture-supporting Ability. In 20 dentulous subjects, pseudopalatal plates were affixed to the palatal mucosa. The relief at the median palatal plate was categorized as: No-relief, 0.25 mm relief, and 0.50 mm relief. All the results were recorded and analysed by SPSS software. Results: During the pain onset, both clenching force and subsidence of the palatal mucosa in the 0.25 and 0.50-mm relief conditions were greater than those under the no-relief condition. The results were found to be statistically significant. However, while comparing in between the 0.25 and 0.50 mm relief conditions, there was no significant difference. Conclusion: The relief area of maxillary full dentures suitable for individual patients was determined in an objective and convenient manner with improved accuracy using this technique