EFFECT OF NON-VOLATILE SOLVENT AND EXCIPIENT RATIO ON FLOW AND CONSOLIDATION PROPERTIES OF POWDER BLEND FOR LIQUISOLID COMPACTS

Objective: To study the effect of non-volatile solvent and excipient ratio on flow and consolidation properties of powder blend for liquisolid compacts.Methods: The effect of non-volatile solvent and excipient ratio on flow and consolidation properties of powder blend for liquisolid compacts was studied. Tween 20, microcrystalline cellulose and colloidal silicon dioxide were selected as non-volatile solvent, carrier and coating material respectively. A central composite statistical design with 2 factors, 5 levels, and 13 runs was selected for the study. Quantity of Tween 20 and excipient ratio were selected as independent factors and an angle of repose, Carr's index and Hausner ratio were selected as responses indicative of flow and consolidation properties.Results: From the statistical analysis of the data obtained for an angle of repose it was found that the quadratic model was not significant. The response surface quadratic models obtained for Carr's index and Hausner ratio were found to be significant. Both responses were much influenced by the quantity of non-volatile solvent than the excipient ratio. Both the independent factors were observed to have interaction. But the interactions were statistically insignificant.Conclusion: The selected independent factors were found to be influential on flow and consolidation properties of powder blend for liquisolid compacts. The results of this study could be used for selection of appropriate systems for the preparation of liquisolid blends with tailored flow and consolidation properties.Â