口腔インプラント室における臨床統計観察

In November 1994, the Oral Implant Room was established as a clinic at the Dental Hospital of Iwate Medical University School of Dentistry. Since then, with the cooperation of the implant committee members recommended from each hospital department, we have performed treatment for the recovery of stomatognathic function. Therefore, with the goal of understanding the results of the Oral Implant Center, the clinical statistics of the treatment provided in the 14 years and 5 months between its opening and March 2009 were assembled, and the following results were obtained. 1. There were 148 cases of implantation involving 129 patients (54 men, 75 women). 2. Mean age at time of implantation was 50.6 years. Individuals in their 50s outnumbered those of other decades, and women outnumbered men. 3. A total of 513 implants were implanted (192 maxilla, 321 mandible), with an average of 3.5 implants per person. 4. The average time between primary surgery and secondary surgery was 5 months 24 days for the maxilla and 3 months 17 days for the mandible. 5. Regarding the distribution of implants, 52.6% were mandibular free-end and 29.3% were in the anterior maxilla. 6. Of the implant patients, 10.7% were smokers and 24.8% were drinkers. 7. The survival rate for the implants was 97.9%

THYMIDYLATE SYNTHETASE AND THYMIDINE KINASE ACTIVITIES IN DMH-INDUCED COLON CARCINOMAS IN RATS AND EFFECTS OF UFT

Carcinoma of the colon was induced in rats by injection of a carcinogen 1,2-dimethylhydrazine (DMH), and thymidylate synthetase (TS) and thymidine kinase (TK) activities, which catalyze the biosynthesis of dTMP by the de novo pathway and the salvage pathway of pyrimidine synthesis, respectively, were measured in normal control colon, DMH-treated normal colon, and DMH­ induced colon carcinoma with or without administration of two doses of an anti-cancer drug UFT (a combination of tegafur and uracil).TS and TK activities were both increased after treatment with DMH, markedly in colon carcinoma tissue, and to a lesser degree in normal-appearing colon tissue. This phenomenon is well explained by the hypothesis that biochemical alterations of DNA-synthesizing enzyme activities occur as a preliminary step prior to the development of overt cancerous transformation.A low dose of UFT inhibited TS activity but enhanced TK activity, therefore, the salvage pathway may compensate for the reduced level of the de novo synthesis. On the other hand, a large dose of UFT reduced both TS and TK activities, perhaps due to cytotoxic effects of UFT incorporation into RNA