6 research outputs found
Energy-efficient Multifunctional Sensors based on Semiconductor Devices.
- Author
- Publication venue
- Publication date
- 01/01/2015
- Field of study
The growing potential of telemedicine and on-body health monitoring has led to the emergence of a new set of challenges associated with chemical, biological and other kinds of sensors that may be needed to facilitate integration with wearable devices. This thesis is aimed at addressing some of these challenges via the use of novel semiconductor device architectures in ways that facilitate significant advances in energy efficiency, miniaturization and cost effectiveness of traditional sensing techniques.
For displays, organic light emitting devices (OLED) offer several unprecedented advantages over conventional displays, including flexibility, compactness, and superior power efficiency. However, the touch sensing capability in such devices is usually provided by capacitive or resistive sensors overlaid on the main display that increase bulkiness. Integration of touch sensing with the imaging plane of the display could dramatically reduce thickness, improve reliability, and enhance sensing resolution. This thesis reports a novel physical effect in OLEDs that could allow touch sensing to be performed by the image-forming pixel itself. In addition to studying the fundamental physical mechanism by which this sensing proceeds, an efficient single pixel OLED that generates changes in electrical current upon touch is discussed.
Another new challenge in wearable electronics is limited on-board power, due to growing power requirements to support a larger number of functions, and a relatively low energy density of batteries. At the same time, a considerable amount of research in recent years has been dedicated to developing novel biochemical sensors that can be integrated with wearables. To address these two emerging challenges, a modified dye-sensitized solar cell is designed to detect common contaminants in drinking water (e.g. metal ions), while powering its own operation by converting absorbed ambient light into an electrical signal.
Finally, a simple, cost-effective chemiluminescence detection scheme is that is applicable to a wide variety of substances, ranging from environmental contaminants to biomarkers, is demonstrated. We expect that further improvements in the optical collection efficiency of the reaction chamber will result in detection limits in the single nanomolar regime, potentially unlocking a broad range of field and point-of-care diagnostic applications.PhDMaterials Science and EngineeringUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/113321/1/kanika_1.pd
Improved Market Basket Analysis with Utility Mining
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Selectivity Tailoring in Liquid Phase Oxidation Over MWNT-Mn 3
- Author
- Abhik Banerjee
- An G.
- Antunes E. F.
- Apte S. K.
- Audi A. A.
- Bielanski A.
- Burdock G. A.
- Chandrashekhar V. Rode
- Clonts K. E.
- Dadyburjor D. B.
- Edwards H. W.
- Garade A. C.
- Grootendorst E.
- Hu L.
- Jiao F.
- Kanika L. Agrawal
- Kshirsagar V. S.
- Kshirsagar V. S.
- Kshirsagar V. S.
- Lee G. W.
- Lee S. W.
- Liu Y.
- Makwana V. D.
- Mandakini Biswal
- Milone C.
- Muduli S.
- Mukherjee G. D.
- Palaniselvam T.
- Peeters M. P.
- Poss A. J.
- Pradip Pachfule
- Ramana G. V.
- Rao D. V.
- Rode C. V.
- Rode C. V.
- Satishchandra B. Ogale
- Sharma S. N.
- Sittig M.
- Sokolovskii V. D.
- Stobhe E. R.
- Torii S.
- Vivek R. Mate
- Vivek V. Dhas
- Wang F.
- Wang F.
- Wang F.
- Xie X.
- Yamashita T.
- Yamashita T.
- Yu T.
- Yumin L.
- Zhang H.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends
- Author
- Alessandro Invernizzi
- Aman Sharma
- Anastasia Tasiopoulou
- Aniruddha Agarwal
- Bahram Bodaghi
- Bhaskar Gupta
- Bruttendu Moharana
- Carl P. Herbort
- Carlos Pavesio
- Debra A. Goldstein
- Dhananjay Raje
- Dinesh Visva Gunasekaran
- Emmett Cunningham
- Ester Carreño
- Hassan Al-Dhibi
- Ho Su Ling
- Ilknur Tugal-Tutkun
- Julio J. González-López
- Jyotirmay Biswas
- Kalpana Babu
- Kanika Aggarwal
- Kusum Sharma
- Luca Cimino
- Mamta Agarwal
- Manfred Zierhut
- Manisha Agarwal
- Mark Westcott
- Moncef Khairallah
- Nicholas Jones
- Onn Min Kon
- Padmamalini Mahendradas
- Peter McCluskey
- Quan Dong Nguyen
- Ramandeep Singh
- Reema Bansal
- Richard Lee
- Ruchi Vala
- Rupesh Agrawal
- Sarakshi Mahajan
- Sengal Nadarajah
- Sharanya Abraham
- Shishir Narain
- Simona Esposti
- Sofia Androudi
- Somasheila L. Murthy
- Soon Phaik Chee
- Soumayava Basu
- Stephen Teoh
- Talin Barisani-Asenbauer
- Vishali Gupta
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Comparative Proteomics Reveals a Role for Seed Storage Protein AmA1 in Cellular Growth, Development, and Nutrient Accumulation
- Author
- Agrawal L.
- Ahsan N.
- Albert R.
- Alm R.
- Ambard-Bretteville F.
- Asis Datta
- Bachem C. W. B.
- Bahrami A. R.
- Balasubramanian R.
- Bechtel D. B.
- Beckner M. E.
- Bellincampia D.
- Bellucci M.
- Bhushan D.
- Blanchoin L.
- Brazhnik P.
- Brown A. P.
- Burks C.
- Cai H.
- Calvert C. M.
- Chaiyarit S.
- Chakraborty N.
- Chakraborty S.
- Chakraborty S.
- Chakraborty S.
- Chen Z. Y.
- Chevalier F.
- Choudhary M. K.
- Cilia M.
- Conlin C. A.
- Corbesier L.
- Crofts A. J.
- Curreem S. O. T.
- Dai S. J.
- de Boer A. H.
- de la Fuente A.
- de la Fuente A.
- DeRocher A.
- Do A.
- Du L.
- Dussert S.
- Fisher D. I.
- Forchhammer K.
- Forde B. G.
- Freedman R. B.
- Fujino K.
- Gallardo K.
- Giovanelli J.
- Glaczinski H.
- Grudkowska M.
- Gupta R. B.
- Hagen G.
- Hajduch M.
- Hecker M.
- Herbers H.
- Herbik A.
- Herrero M.
- Hesse H.
- Hurkman W. J.
- Hussey P. J.
- Imai J.
- Ishihama Y.
- Jefferson R. A.
- Jin M.
- Jungblut P. R.
- Kanika Narula
- Kausch K. D.
- Kloosterman B.
- Knill T.
- Koch K. E.
- Kolomiets M. V.
- Koning A. J.
- Lalit Agrawal
- Larrainzar E.
- Lehesranta S. J.
- Lehesranta S. J.
- Levican G.
- Li L.
- Liu H.
- Lockhart D. J.
- Lu G.
- Lu J.
- Luce K.
- Luque C. M.
- Lynch J.
- Mandal S.
- Matsui K.
- Matsuki T.
- Mauch F.
- Mc Cool S.
- McGregor E.
- Meagher R. B.
- Melan M. A.
- Molvig L.
- Moreira J. M. A.
- Muslin A. J.
- Muslin A. J.
- Mutwil M.
- Neckers L.
- Neer E. J.
- Niranjan Chakraborty
- Novak P.
- Oberschall A.
- Oszvald M.
- O’Kelly I.
- Palenchar P.
- Palmer A.
- Pandey A.
- Pappan K.
- Paul A.-L.
- Pelacho A. M.
- Perkins D. N.
- Pernas M.
- Peterson R. L.
- Philip N.
- Poetsch A.
- Pots A. M.
- Raina A.
- Reeve R. M.
- Rietza S.
- Roessner U.
- Roessner U.
- Ruebelt M. C.
- Rutherford S. L.
- Ryu S. B.
- Saeed A. I.
- Sanchez-Bel P.
- Sanchez-Quiles V.
- Sangster T. A.
- Saravitz D. M.
- Sarmah B.
- Schmidt M. A.
- Schmidt W.
- Schneper L.
- Schuler T. H.
- Scossa F.
- Sehnke P. C.
- Sghaier-Hammami B.
- Shannon P.
- Shewry P. R.
- Shewry P. R.
- Shimoni Y.
- Shubhendu Shekhar
- Singh B. K.
- Sobhanian H.
- Sonnewald U.
- Steppan C.
- Stitt M.
- Stitt M.
- Stupar R. M.
- Subhra Chakraborty
- Sudip Ghosh
- Suzui N.
- Swaraj Basu
- Sweetlove L. J.
- Tamas C.
- Taylor N. L.
- Wang R.
- Wang R.
- Wang W.
- Weber H.
- Weeda S. M.
- Yan S. P.
- Yang Y.
- Yoon J. H.
- Young J. C.
- Zhang L.
- Zhang L. J.
- Zolla L.
- Zrenner R.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- Field of study
Contributory presentations/posters
- Author
- A. A. Tikhomirov
- A. Amadei
- A. Bhattacharya
- A. Bogdanov
- A. C. Campos de Carvalho
- A. C. Mauricio
- A. C. Mauricio
- A. Cole
- A. D. Beniaminov
- A. D. Kaulen
- A. Di Nola
- A. Di Nola
- A. Emanuele
- A. Faraone
- A. G. Degermendzhy
- A. G. Sizykh
- A. G. Tonevitsky
- A. German
- A. Gries
- A. H. Parola
- A. Holzenburg
- A. I. El-Awadi
- A. I. Kuzmenko
- A. Ishino
- A. J. W. G. Visser
- A. J. Wein
- A. Jellali
- A. Johnson
- A. K. Bandyopadhyay
- A. K. Basak
- A. K. Basak
- A. K. Bera
- A. K. Bera
- A. K. Mishra
- A. K. Mishra
- A. K. Pal
- A. K. Pal
- A. K. Sharma
- A. K. Singh
- A. K. Tonkikh
- A. Khachatryan
- A. Kumar
- A. L. Barker
- A. L. Shvaleva
- A. M. Eissa
- A. M. Lynn
- A. M. Rebelo da Costa
- A. N. Antonovich
- A. Nandy
- A. Ongarbaev
- A. Pande
- A. Pramanik
- A. S. Dukhin
- A. S. Ghatpande
- A. Saitoh
- A. Sarai
- A. Sarai
- A. Spisni
- A. Srinivasan
- A. Srintvasan
- A. Surolia
- A. Surolia
- A. Takahashi
- A. Tikhonov
- A. V. Avetisyan
- A. Yayon
- A. Zanina
- Abdalla S. Ahmed
- Abraham H. Parola
- Achintya Das
- Adrian Neagu
- Adrian Neagu
- Adriana Solovicova
- Akira Goto
- Akira R. Kinjo
- Alan J. Waring
- Alberto Furia
- Alex Ninaber
- Alexander A. Yaroslavov
- Alexander V. Chalyi
- Alexandra Dinu
- Alexandra T. Balaban
- Alexandra Zahradniková
- Alexei N. Vasil’ev
- Alexey Surin
- Alfred Pingoud
- Alfredo Di Nola
- Almeida Rodrigo
- Amal K. Bera
- Amita Joshi
- Amitabha Chattopadhyay
- Amitabha Chattopadhyay
- Amy B. Heagle
- Ana Damjanović
- Andrew Badley
- Andrew Thompson
- Andrey V. Krylov
- András Dér
- András Hámori
- András Szilágyi
- Anil K. Singh
- Anil K. Singh
- Anil Kumar
- Anil Saran
- Anirban Ghosh
- Anjana Sen
- Anna Gabrielian
- Annie Morin
- Antonella Bandiera
- Anunay Samanta
- Anurae Varshney
- Anwer Mujeeb
- Araken S. Werneck
- Arghya Ray
- Arghya Ray
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- Atsushi Ohnishi
- Atta Ahmad
- Atta Ahmad
- Atta Ahmad
- Avadhesha Surolia
- Ayumu Saito
- B. -L. Johansson
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- B. Sengupta
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- B. Sundaravadivel
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- B. Žekš
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- Bas Gobets
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- Basuthkar J. Rao
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- Berenice Venegas-Cotero
- Bernadette Heyd
- Bernard S. Gerstman
- Bernd Mayer
- Bina Chandani
- Bindu Pillai
- Bindu Pillay
- Bishnu P. Chatterjee
- Bishnu P. Chatterjee
- Bojan Božič
- Bonn Kirn
- Boojala V. B. Reddy
- Boris S. Zhorov
- Borys Kierdaszuk
- Bosco Ho
- Boštjan Žekš
- Brian D. Gute
- C. Barrias
- C. Barrias
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- C. Cortez-Maghelly
- C. E. Naylor
- C. ElHamel
- C. G. Suresh
- C. Hariharan
- C. L. Khetrapal
- C. Lupusoru
- C. Naylor
- C. P. Winlove
- C. R. Grace
- C. Ramakrishnan
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- C. Savino
- C. Sivakama Sundari
- C. Tetreau
- C. Tetreau
- C. Travaglini-Allocatelli
- Calin Apetrei
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- Ch. Betzel
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- Ch. Mohan Rao
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- Chicko Nakazawal
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- Claudia Capurro
- Cor J. A. M. Wolfs
- Cornelis W. Hilbers
- Cécile Breyton
- D. Balasubramanian
- D. Bulone
- D. Bulone
- D. Cucu
- D. Flatters
- D. G. Weiss
- D. Gazdaru
- D. Genest
- D. Heitzmann
- D. Hicks
- D. Isabey
- D. J. Stratimirovic
- D. K. Bharadwaj
- D. K. Chang
- D. Lairez
- D. Lairez
- D. Lavalette
- D. Loganathan
- D. M. Salunke
- D. Macherel
- D. Martin
- D. Mihailescu
- D. N. Woolfeon
- D. N. Woolfson
- D. N. Woolfson
- D. O’Hare
- D. P. Millar
- D. Pines
- D. R. Alieva
- D. Roccatano
- D. S. Gurumurthy
- D. S. Moss
- D. Savitri
- D. Sriram
- D. Tchitchkan
- D. V. S. Jain
- D. Yu. Rogozin
- David C. Cullen
- David D. Thomas
- David L. Beveridge
- David Opitz
- David Stopar
- Debashree Bandyopadhyay
- Debashree Bandyopadhyay
- Deborah Keszenman
- Deepak Nair
- Deepak Sharma
- Deepak Sharma
- Deepti Jain
- Deepti Jain
- Deepti Warrier
- Delphine Flatters
- Denise Mills
- Derek N. Woolfson
- Devapriva Choudhury
- Devesh Kumar
- Devesh Kumar
- Dhananjay Bhattacharyya
- Dhananjay Bhattacharyya
- Diana Lungeanu
- Diederichs
- Dietmar J. Manstein
- Dietmar J. Manstein
- Digambar V. Behere
- Dinakar M. Salunke
- Dinakar M. Salunke
- Dinakar M. Salunke
- Dinesh Singh
- Dipti Marathe
- Dong-cai Liang
- Dragan Amic
- Drago Beslo
- Dubravka Krilov
- Dušanka Janežič
- Dénes Lőrinczv
- E. A. Chernitsky
- E. A. Chernitsky
- E. A. Lycholat
- E. A. Lycholat
- E. Carmen Candreva
- E. D. Getzoff
- E. Dé
- E. E. F. Haya
- E. E. Laukhina
- E. E. Minyat
- E. E. Pohl
- E. G. Alirzayeva
- E. Gornik
- E. I. Kovalenko
- E. I. Slobozhanina
- E. K. Matthews
- E. L. de Beer
- E. Loots
- E. M. Zaitseva
- E. M. Zaitseva
- E. M. Zdobnov
- E. N. Esimbekova
- E. Neu
- E. P. Passos
- E. Papp
- E. Pauthe
- E. Pines
- E. Planus
- E. R. Kandimalla
- E. Sackmann
- E. Savio-Galimberti
- E. T. Tadjibaeva
- E. V. Gritsenko
- E. V. Nemtseva
- E. Y. Isacoff
- Ed Morris
- Eglė Merkienė
- Eimer Tuite
- Elena A. Kotova
- Eleonora Marsich
- Elia Nunes
- Elia Nunes
- Elisa Del Terra
- Elisabeth Adjadj
- Elizabeth A. Doherty
- Elmar Weinhold
- Eric Ezra
- Erich Staudegger
- Erik M. Shapiro
- Erik R. P. Zuiderweg
- Erisa Harada
- Ernesto R. Caffarena
- Essa Alfahel
- Eugenia Kovacs
- Eugenia Kovacs
- Eva Urbánková
- Evans Coutinho
- Evans Coutinho
- F. Barceló
- F. Cutruzzolà
- F. de Paula
- F. Galtet
- F. M. Ali
- F. M. El-Refaei
- F. Nomura
- F. Pichierri
- F. Sevšek
- F. Tama
- Fateh S. Nandel
- Fateh S. Nandel
- Franciska Könczöl
- Franco Quadrifoglio
- Frank A. Ferrone
- Frauke Christ
- Fumi Takazawatt
- Fumimasa Nomura
- Fuyuhiko Inagaki
- G. A. Nagana Gowda
- G. A. Spooner
- G. Arcovito
- G. Benedek
- G. Björk
- G. C. Papageorgiou
- G. Chakshusmathi
- G. Garab
- G. Gomišček
- G. Govil
- G. Govil
- G. H. Rossmanith
- G. Horváth
- G. I. Mihalas
- G. Karthikeyan
- G. Kratz
- G. Krishnamoorthy
- G. Krishnamoorthy
- G. M. Kostner
- G. Macovievici
- G. Maisano
- G. Molle
- G. N. Semenkova
- G. Nagenagowda
- G. O. Nobuhiro
- G. P. Gorbeako
- G. P. S. Raghava
- G. Potikyan
- G. Ravindra Kumar
- G. S. Kalacheva
- G. S. Lakshmikanth
- G. Thiel
- G. Titescu
- G. Uretzky
- G. V. Donchenko
- G. Wübeller
- Gabor Tigyi
- Gary D. Bernard
- Geetanjali Bansal
- Geetha Gopalakrishnan
- Gennady V. Semisotnov
- Giedrius Vilkaitis
- Giorgio Forti
- Giorgio Forti
- Giorgio Manzini
- Giovanni Finazzi
- Girish S. Ratnaparkhi
- Girjesh Govil
- Girjesh Govil
- Gong Yandao
- Gopal Khetawat
- Goran Bačić
- Gosu Ramachandraiah
- Gota Kawai
- Gotam K. Jarori
- Gottfried Köhler
- Gotz Pilarczyk
- Gouri S. Jas
- Gregory D. Grunwald
- Greta Pifat
- Guilhem Lerat
- Gunjan Agarwal
- Győző Garab
- Gábor Horváth
- H. Aiba
- H. Amenitsch
- H. Arakelian
- H. Berry
- H. Berry
- H. Blom
- H. C. Pant
- H. Chosrowjan
- H. Dreyfus
- H. Fujita
- H. G. Ferreira
- H. Gilboa
- H. Hama-Inaba
- H. Hermel
- H. Hotani
- H. Hotani
- H. Hotani
- H. Ichinose
- H. J. C. Berendsen
- H. Jörnvall
- H. Kleszczyńska
- H. Kono
- H. Kono
- H. M. Pike
- H. M. Sonawat
- H. Matsuo
- H. Mori
- H. Möhwald
- H. N. Mallick
- H. Ohshima
- H. Ohyama
- H. S. Atreya
- H. S. Savithri
- H. Tagami
- H. Tochio
- H. Uedaira
- H. Uedaira
- H. Van Dael
- Han-qing Zhou
- Hana Bartošková
- Hang-fang Feng
- Hans A. Heus
- Haripada Maity
- Harpreet Kaur
- HE. Sngrvan
- Heinz Sklenar
- Heinz Welfle
- Henri Grosjean
- Henri Grosjean
- Herbert Lijima
- Herbert van Amerongen
- Herman J. C. Berendsen
- Herman J. C. Berendsen
- Hidefumi Kitazawa
- Hideo Akutsu
- Hideo Akutsu
- Hidetake Miyata
- Hiroaki Hirata
- Hirokazu Hotani
- Hirokazu Hotani
- Hiromasa Yagi
- Hironori Nakamura
- Hiroshi Kihara
- Hiroshi Nakashima
- Hirotomo Takaesu
- Hong-Wei Wang
- Hong-Wei Wang
- Hubert Thole
- I. A. Lopes
- I. A. Nikolenko
- I. A. Zalyvsky
- I. D. Volotovski
- I. Dey
- I. E. Sukovataya
- I. F. Fraceto
- I. Haulica
- I. Hayata
- I. I. Agapov
- I. M. Guseinova
- I. Morisima
- I. P. Sugar
- I. Radulcscu
- I. S. Zulfugarov
- I. Simidjiev
- I. Stefanescu
- I. V. Sokolova
- I. Venekei
- Ileana Petcu
- Ilya N. Shindylov
- Indira H. Shrivastava
- Indra Brata Jha
- Ira
- Isao Tanaka
- Ishida Masaru
- István Pomozi
- Ivan Dimitrov
- Ivan Ortega Blake
- Ivan Tahradník
- Ivan Zahradník
- Ivo H. M. van Stokkum
- J. A. Aliev
- J. A. Hypolite
- J. A. Khan
- J. A. Lebrón
- J. An
- J. An
- J. Antosiewicz
- J. Balaji
- J. Barchir
- J. Bourguignon
- J. Chapman
- J. de Xammar Oro
- J. E. Ponce-Homos
- J. F. Eccelston
- J. F. Y. Hoh
- J. G. Molotkovsky
- J. Guharay
- J. Guharay
- J. Guharay
- J. Holm
- J. K. Mohana Rao
- J. Kardos
- J. King
- J. Kuczera
- J. L. Ambrus
- J. P. Gardner
- J. P. Reeves
- J. P. Reeves
- J. Pande
- J. Payne
- J. Pelta
- J. Pelta
- J. Pines
- J. Portugal
- J. R. Grigera
- J. Raul Grigera
- J. S. Singh
- J. Sahel
- J. Shobini
- J. Sun
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- Vivian Stojanoff
- Vlnod Bhakuni
- W. A. Varanda
- W. Bild
- W. H. Sawyer
- W. J. Chien
- W. Müller
- W. Schmahl
- W. Seidenbusch
- Wang Bao Han
- Wang Jushuo
- Wang Zhi Xin
- Wei-ying Cheng
- Wen-rui Chang
- Werner Kühlbrandt
- William A. Eaton
- Wolfgang Höhne
- Wolfgang Jahnke
- Wolfgang Wende
- Xiao-jian Hu
- Xun Shen
- Y-M. Zheng
- Y. -H. Sanejouand
- Y. Blouquit
- Y. Husimi
- Y. Kirino
- Y. Kishimoto
- Y. Kyogoku
- Y. Lin
- Y. M. Allakhverdieva
- Y. Nakato
- Y. Pesotskaya
- Y. Rubin
- Y. Shibata
- Y. Suezaki
- Y. U. Sasidhar
- Ya. I. Estrin
- Yasuhiro Kumaki
- Yasunori Yokoyama
- Yogesh Kumar
- Yoichi Hayakawa
- Yoichiro Ito
- Yoshihiro Kobashigawa
- Yoshitoshi
- Yoshiyuki Amemiya
- Yosiyuki Sowa
- Yu. Babayan
- Yu. P. Blagoy
- Yu. P. Chukova
- Yu. S. Babayan
- Yuan Zheng
- Yuji Kimura
- Yuki Fukuoka
- Yuki Nakagawa
- Yuling Yan
- Yuri Mukai
- Yuri Mukai
- Yuri N. Antonenko
- Yuriko Yamagata
- Yuriko Yamagata
- Yusuke Iguchi
- Yuzuru Husimi
- Yves Blouquit
- Z. B. Li
- Z. Combos
- Z. Cseh
- Z. Földes-Papp
- Z. Gombos
- Z. Guttenberg
- Z. Lobo
- Z. S. Várkonyi
- Z. Stolič
- Z. Tronteli
- Zeno Földes-Papp
- Zhao Nanming
- Zhi-hong Zhang
- Zs. Várkonyi
- Zvi Priel
- Á. Bódi
- Éric Quinjou
- Ü. Mets
- Č. N. Radenović
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study