POTENTIAL HYPOGLYCEMIC EFFECT OF ESSENTIAL OIL OF CITRUS RETICULATA IN WISTAR RATS

ABSTRACT The essential oil of Citrus reticulata is reported to have antidiabetic activity, but there are no reports on their interaction with commonly used hypoglycemic agent like glibenclamide. The present study was planned to elucidate hypoglycemic effect of essential oil of Citrus reticulata (ECR) and its interaction with glibenclamide in euglycemic and hyperglycemic rats. Euglycemic and alloxan induced hyperglycemic male Wistar rats were orally administered, the essential oil, glibenclamide (0.9mg/kg), subhypoglycemic dose (SHD) of ECR and SHD of glibenclamide (0.45mg/kg) in single dose separately in different groups blood glucose was estimated using glucometer at 0, 2, 4, 6, 8 and 12hrs. The essential oil of Citrus reticulata exhibited significant hypoglycemic activity, while it did not potentiate the hypoglycemic activity of glibenclamide