2,454 research outputs found
Techno-economic evaluation of reducing shielding gas consumption in GMAW whilst maintaining weld quality
A new method of supplying shielding gases in an alternating manner has been developed to enhance the efficiency of conventional gas metal arc welding (GMAW). However, the available literature on this advanced joining process is very sparse and no cost evaluation has been reported to date. In simple terms, the new method involves discretely supplying two different shielding gases to the weld pool at predetermined frequencies which creates a dynamic action within the liquid pool. In order to assess the potential benefits of this new method from a technical and cost perspective, a comparison has been drawn between the standard shielding gas composition of Ar/20%CO2, which is commonly used in UK and European shipbuilding industries for carbon steels, and a range of four different frequencies alternating between Ar/20%CO2 and helium. The beneficial effects of supplying the weld shielding gases in an alternating manner were found to provide attractive benefits for the manufacturing community. For example, the present study showed that compared with conventional GMAW, a 17 per cent reduction in total welding cost was achieved in the case of the alternating gas method and savings associated with a reduction in the extent of post-weld straightening following plate distortion were also identified. Also, the mechanical properties of the alternating case highlighted some marginal improvements in strength and Charpy impact toughness which were attributed to a more refined weld microstructure
Tracking Objects as Points
Tracking has traditionally been the art of following interest points through
space and time. This changed with the rise of powerful deep networks. Nowadays,
tracking is dominated by pipelines that perform object detection followed by
temporal association, also known as tracking-by-detection. In this paper, we
present a simultaneous detection and tracking algorithm that is simpler,
faster, and more accurate than the state of the art. Our tracker, CenterTrack,
applies a detection model to a pair of images and detections from the prior
frame. Given this minimal input, CenterTrack localizes objects and predicts
their associations with the previous frame. That's it. CenterTrack is simple,
online (no peeking into the future), and real-time. It achieves 67.3% MOTA on
the MOT17 challenge at 22 FPS and 89.4% MOTA on the KITTI tracking benchmark at
15 FPS, setting a new state of the art on both datasets. CenterTrack is easily
extended to monocular 3D tracking by regressing additional 3D attributes. Using
monocular video input, it achieves 28.3% [email protected] on the newly released
nuScenes 3D tracking benchmark, substantially outperforming the monocular
baseline on this benchmark while running at 28 FPS.Comment: ECCV 2020 Camera-ready version. Updated track rebirth results. Code
available at https://github.com/xingyizhou/CenterTrac
Response to imatinib rechallenge in a patient with a recurrent gastrointestinal stromal tumor after adjuvant therapy: a case report
<p>Abstract</p> <p>Introduction</p> <p>Adjuvant imatinib improves recurrence-free survival of patients following resection of primary KIT-positive gastrointestinal stromal tumors. However, it is unknown whether patients who previously received adjuvant imatinib therapy will respond to imatinib rechallenge as treatment for recurrent disease. Here we present the first report documenting the benefits of imatinib rechallenge in a patient previously exposed to imatinib during adjuvant treatment.</p> <p>Case presentation</p> <p>A 51-year-old Asian woman with a wedge-resected primary gastric gastrointestinal stromal tumor at high risk of relapse underwent two years of adjuvant treatment with imatinib. Only 10 months after the completion of adjuvant imatinib treatment, a computed tomography scan revealed gastrointestinal stromal tumor recurrence in this patient, with multiple peritoneal nodules in the upper abdomen being detected. Our patient was rechallenged with imatinib 400 mg/day and had a partial response after one month of treatment. Imatinib rechallenge was well tolerated by our patient; the only adverse events she experienced were grade 1 edema, anemia and fatigue. Our patient maintained a partial response two years and six months after the imatinib rechallenge. However, computed tomography scans three months later showed that our patient had disease progression.</p> <p>Conclusions</p> <p>This case report demonstrates that a patient with a gastrointestinal stromal tumor who had previously received adjuvant imatinib therapy responded to imatinib rechallenge as treatment for her recurrent disease. These results indicate that imatinib sensitivity can be maintained in a patient with previous exposure to adjuvant imatinib therapy.</p
Pure-glue hidden valleys through the Higgs portal
We consider the possibility that the Higgs boson can act as a link to a
hidden sector in the context of pure-glue hidden valley models. In these models
the standard model is weakly coupled, through loops of heavy messengers fields,
to a hidden sector whose low energy dynamics is described by a pure-Yang-Mills
theory. Such a hidden sector contains several metastable hidden glueballs. In
this work we shall extend earlier results on hidden valleys to include
couplings of the messengers to the standard model Higgs sector. The effective
interactions at one-loop couple the hidden gluons to the standard model
particles through the Higgs sector. These couplings in turn induce hidden
glueball decays to fermion pairs, or cascade decays with multiple Higgs
emission. The presence of effective operators of different mass dimensions,
often competing with each other, together with a great diversity of states,
leads to a great variability in the lifetimes and decay modes of the hidden
glueballs. We find that most of the operators considered in this paper are not
heavily constrained by precision electroweak physics, therefore leaving plenty
of room in the parameter space to be explored by the future experiments at the
LHC.Comment: 44 pages, 16 figures. Major revision for JHEP, corrected an error in
Eq. 5.1, comments adde
A Definitive Signal of Multiple Supersymmetry Breaking
If the lightest observable-sector supersymmetric particle (LOSP) is charged
and long-lived, then it may be possible to indirectly measure the Planck mass
at the LHC and provide a spectacular confirmation of supergravity as a symmetry
of nature. Unfortunately, this proposal is only feasible if the gravitino is
heavy enough to be measured at colliders, and this condition is in direct
conflict with constraints from big bang nucleosynthesis (BBN). In this work, we
show that the BBN bound can be naturally evaded in the presence of multiple
sectors which independently break supersymmetry, since there is a new decay
channel of the LOSP to a goldstino. Certain regions of parameter space allow
for a direct measurement of LOSP decays into both the goldstino and the
gravitino at the LHC. If the goldstino/gravitino mass ratio is measured to be
2, as suggested by theory, then this would provide dramatic verification of the
existence of multiple supersymmetry breaking and sequestering. A variety of
consistent cosmological scenarios are obtained within this framework. In
particular, if an R symmetry is imposed, then the gauge-gaugino-goldstino
interaction vertices can be forbidden. In this case, there is no bound on the
reheating temperature from goldstino overproduction, and thermal leptogenesis
can be accommodated consistently with gravitino dark matter.Comment: 10 pages, 5 figures, title changed to match the version published in
JHE
Baryon Washout, Electroweak Phase Transition, and Perturbation Theory
We analyze the conventional perturbative treatment of sphaleron-induced
baryon number washout relevant for electroweak baryogenesis and show that it is
not gauge-independent due to the failure of consistently implementing the
Nielsen identities order-by-order in perturbation theory. We provide a
gauge-independent criterion for baryon number preservation in place of the
conventional (gauge-dependent) criterion needed for successful electroweak
baryogenesis. We also review the arguments leading to the preservation
criterion and analyze several sources of theoretical uncertainties in obtaining
a numerical bound. In various beyond the standard model scenarios, a realistic
perturbative treatment will likely require knowledge of the complete two-loop
finite temperature effective potential and the one-loop sphaleron rate.Comment: 25 pages, 9 figures; v2 minor typos correcte
Asymmetric Origin for Gravitino Relic Density in the Hybrid Gravity-Gauge Mediated Supersymmetry Breaking
We propose the hybrid gravity-gauge mediated supersymmetry breaking where the
gravitino mass is about several GeV. The strong constraints on supersymmetry
viable parameter space from the CMS and ATLAS experiments at the LHC can be
relaxed due to the heavy colored supersymmetric particles, and it is consistent
with null results in the dark matter (DM) direct search experiments such as
XENON100. In particular, the possible maximal flavor and CP violations from the
relatively small gravity mediation may naturally account for the recent LHCb
anomaly. In addition, because the gravitino mass is around the asymmetric DM
mass, we propose the asymmetric origin of the gravitino relic density and solve
the cosmological coincident problem on the DM and baryon densities \Omega_{\rm
DM}:\Omega_{B}\approx 5:1. The gravitino relic density arises from asymmetric
metastable particle (AMP) late decay. However, we show that there is no AMP
candidate in the minimal supersymmetric Standard Model (SM) due to the robust
gaugino/Higgsino mediated wash-out effects. Interestingly, AMP can be realized
in the well motivated supersymmetric SMs with vector-like particles or
continuous U(1)_R symmetry. Especially, the lightest CP-even Higgs boson mass
can be lifted in the supersymmetric SMs with vector-like particles.Comment: RevTex4, 21 pages, 1 figure, minor corrections, JHEP versio
Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA
In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA. Using purified components in the presence of ATP-Ξ³S, we have captured in vitro an intermediate in pre-RC assembly that contains a complex between the ORC-Cdc6 and Cdt1-MCM2-7 heteroheptamers called the OCCM. Cryo-EM studies of this 14-subunit complex reveal that the two separate heptameric complexes are engaged extensively, with the ORC-Cdc6 N-terminal AAA+ domains latching onto the C-terminal AAA+ motor domains of the MCM2-7 hexamer. The conformation of ORC-Cdc6 undergoes a concerted change into a right-handed spiral with helical symmetry that is identical to that of the DNA double helix. The resulting ORC-Cdc6 helicase loader shows a notable structural similarity to the replication factor C clamp loader, suggesting a conserved mechanism of action
Protein profiling in hepatocellular carcinoma by label-free quantitative proteomics in two west african populations.
Background Hepatocellular Carcinoma is the third most common cause of cancer related death worldwide, often diagnosed by measuring serum AFP; a poor performance stand-alone biomarker. With the aim of improving on this, our study focuses on plasma proteins identified by Mass Spectrometry in order to investigate and validate differences seen in the respective proteomes of controls and subjects with LC and HCC. Methods Mass Spectrometry analysis using liquid chromatography electro spray ionization quadrupole time-of-flight was conducted on 339 subjects using a pooled expression profiling approach. ELISA assays were performed on four significantly differentially expressed proteins to validate their expression profiles in subjects from the Gambia and a pilot group from Nigeria. Results from this were collated for statistical multiplexing using logistic regression analysis. Results Twenty-six proteins were identified as differentially expressed between the three subject groups. Direct measurements of four; hemopexin, alpha-1-antitrypsin, apolipoprotein A1 and complement component 3 confirmed their change in abundance in LC and HCC versus control patients. These trends were independently replicated in the pilot validation subjects from Nigeria. The statistical multiplexing of these proteins demonstrated performance comparable to or greater than ALT in identifying liver cirrhosis or carcinogenesis. This exercise also proposed preliminary cut offs with achievable sensitivity, specificity and AUC statistics greater than reported AFP averages. Conclusions The validated changes of expression in these proteins have the potential for development into high-performance tests usable in the diagnosis and or monitoring of HCC and LC patients. The identification of sustained expression trends strengthens the suggestion of these four proteins as worthy candidates for further investigation in the context of liver disease. The statistical combinations also provide a novel inroad of analyses able to propose definitive cut-offs and combinations for evaluation of performance
Vectorlike Confinement at the LHC
We argue for the plausibility of a broad class of vectorlike confining gauge
theories at the TeV scale which interact with the Standard Model predominantly
via gauge interactions. These theories have a rich phenomenology at the LHC if
confinement occurs at the TeV scale, while ensuring negligible impact on
precision electroweak and flavor observables. Spin-1 bound states can be
resonantly produced via their mixing with Standard Model gauge bosons. The
resonances promptly decay to pseudo-Goldstone bosons, some of which promptly
decay to a pair of Standard Model gauge bosons, while others are charged and
stable on collider time scales. The diverse set of final states with little
background include multiple photons and leptons, missing energy, massive stable
charged particles and the possibility of highly displaced vertices in dilepton,
leptoquark or diquark decays. Among others, a novel experimental signature of
resonance reconstruction out of massive stable charged particles is
highlighted. Some of the long-lived states also constitute Dark Matter
candidates.Comment: 33 pages, 6 figures. v4: expanded discussion of Z_2 symmetry for
stability, one reference adde
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