Novel Josephson Junction Geometries in NbCu bilayers fabricated by Focused Ion Beam Microscope

We explore novel junction configurations as an extension of our established Focused Ion Beam-based low TC SNS Junction fabrication technique. By milling a circular trench (diameter 1 micron, width 50 nm) in a 125 nm Nb 75 nm Cu bilayer we define a superconducting island connected to the bulk of the film by a normal metal barrier and entirely enclosed in-plane by the superconducting film. The circular junction properties can be probed by depositing an insulating layer over the device and drilling a 0.3 micron diameter hole down to the island to allow a Nb via to be deposited. Device behavior has been studied at 4.2 K. An SNS-like current voltage characteristic and Shapiro steps are observed. It is in terms of magnetic field behavior that the device exhibits novel characteristics: as the device is entirely enclosed in type II superconductor, when a magnetic field is applied perpendicular to the plane of the film, only quantized flux can enter the junction. Hence as applied magnetic field is increased the junction critical current is unchanged, then abruptly suppressed as soon as a flux quantum enters (close to the expected value of lower critical field for the film).Comment: 10 pages including 6 figures Minor Corrections inlight of referees' comment

Cosmic Rays during BBN as Origin of Lithium Problem

There may be non-thermal cosmic rays during big-bang nucleosynthesis (BBN) epoch (dubbed as BBNCRs). This paper investigated whether such BBNCRs can be the origin of Lithium problem or not. It can be expected that BBNCRs flux will be small in order to keep the success of standard BBN (SBBN). With favorable assumptions on the BBNCR spectrum between 0.09 -- 4 MeV, our numerical calculation showed that extra contributions from BBNCRs can account for the $^7$Li abundance successfully. However $^6$Li abundance is only lifted an order of magnitude, which is still much lower than the observed value. As the deuteron abundance is very sensitive to the spectrum choice of BBNCRs, the allowed parameter space for the spectrum is strictly constrained. We should emphasize that the acceleration mechanism for BBNCRs in the early universe is still an open question. For example, strong turbulent magnetic field is probably the solution to the problem. Whether such a mechanism can provide the required spectrum deserves further studies.Comment: 34 pages, 21 figures, published versio

Bulk experimental evidence of half-metallic ferromagnetism in doped manganites

We report precise measurements and quantitative data analysis on the low-temperature resistivity of several ferromagnetic manganite films. We clearly show that there exists a T^{4.5} term in low-temperature resistivity, and that this term is in quantitative agreement with the quantum theory of two-magnon scattering for half metallic ferromagnets. Our present results provide the first bulk experimental evidence of half-metallic ferromagnetism in doped manganites.Comment: 4 pages, 4 figure

Vertical Confinement and Evolution of Reentrant Insulating Transition in the Fractional Quantum Hall Regime

We have observed an anomalous shift of the high field reentrant insulating phases in a two-dimensional electron system (2DES) tightly confined within a narrow GaAs/AlGaAs quantum well. Instead of the well-known transitions into the high field insulating states centered around $\nu = 1/5$, the 2DES confined within an 80\AA-wide quantum well exhibits the transition at $\nu = 1/3$. Comparably large quantum lifetime of the 2DES in narrow well discounts the effect of disorder and points to confinement as the primary driving force behind the evolution of the reentrant transition.Comment: 5 pages, 4 figure

Anomalous Scaling of Structure Functions and Dynamic Constraints on Turbulence Simulations

The connection between anomalous scaling of structure functions (intermittency) and numerical methods for turbulence simulations is discussed. It is argued that the computational work for direct numerical simulations (DNS) of fully developed turbulence increases as $Re^{4}$, and not as $Re^{3}$ expected from Kolmogorov's theory, where $Re$ is a large-scale Reynolds number. Various relations for the moments of acceleration and velocity derivatives are derived. An infinite set of exact constraints on dynamically consistent subgrid models for Large Eddy Simulations (LES) is derived from the Navier-Stokes equations, and some problems of principle associated with existing LES models are highlighted.Comment: 18 page

Human papillomavirus 16 E6 induces FoxM1B in oral keratinocytes through GRHL2

High-risk human papillomavirus (HPV) is a major risk factor for oral and pharyngeal cancers (OPCs), yet the detailed mechanisms by which HPV promotes OPCs are not understood. Forkhead box M1B (FoxM1B) is an oncogene essential for cell cycle progression and tumorigenesis, and it is aberrantly overexpressed in many tumors. We previously showed that FoxM1B was the putative target of an epithelial-specific transcription factor, Grainyhead-like 2 (GRHL2). In the current study, we demonstrate that HPV type 16 (HPV-16) E6 induces FoxM1B in human oral keratinocytes (HOKs) and tonsillar epithelial cells (TECs) in part through GRHL2. FoxM1B was barely detectable in cultured normal human oral keratinocytes (NHOKs) and progressively increased in immortalized HOKs harboring HPV-16 genome (HOK-16B) and tumorigenic HOK-16B/BaP-T cells. Retroviral expression of HPV-16 E6 and/or E7 in NHOKs, TECs, and hypopharyngeal carcinoma cells (FaDu) revealed induction of FoxM1B and GRHL2 by the E6 protein but not E7. Both GRHL2 and FoxM1B were strongly induced in the epidermis of HPV-16 E6 transgenic mice and HPVoral squamous cell carcinomas. Ectopic expression of FoxM1B led to acquisition of transformed phenotype in HOK-16B cells. Loss of FoxM1B by lentiviral short hairpin RNA vector or chemical inhibitor led to elimination of tumorigenic characteristics of HOK-16B/BaP-T cells. Luciferase reporter assay revealed that GRHL2 directly bound and regulated the FoxM1B gene promoter activity. Using epithelial-specific Grhl2 conditional knockout mice, we exposed wild-type (WT) and Grhl2 KO mice to 4-nitroquinolin 1-oxide (4-NQO), which led to induction of FoxM1B in the tongue tissues and rampant oral tumor development in the WT mice. However, 4-NQO exposure failed to induce tongue tumors or induction of FoxM1B expression in Grhl2 KO mice. Collectively, these results indicate that HPV-16 induces FoxM1B in part through GRHL2 transcriptional activity and that elevated FoxM1B level is required for oropharyngeal cancer development

Structures for Interacting Composite Fermions: Stripes, Bubbles, and Fractional Quantum Hall Effect

Much of the present day qualitative phenomenology of the fractional quantum Hall effect can be understood by neglecting the interactions between composite fermions altogether. For example the fractional quantum Hall effect at $\nu=n/(2pn\pm 1)$ corresponds to filled composite-fermion Landau levels,and the compressible state at $\nu=1/2p$ to the Fermi sea of composite fermions. Away from these filling factors, the residual interactions between composite fermions will determine the nature of the ground state. In this article, a model is constructed for the residual interaction between composite fermions, and various possible states are considered in a variational approach. Our study suggests formation of composite-fermion stripes, bubble crystals, as well as fractional quantum Hall states for appropriate situations.Comment: 16 pages, 7 figure

Stabilities of nanohydrated thymine radical cations: insights from multiphoton ionization experiments and ab initio calculations

Multi-photon ionization experiments have been carried out on thymine-water clusters in the gas phase. Metastable H2O loss from T+(H2O)n was observed at n ≥ 3 only. Ab initio quantum-chemical calculations of a large range of optimized T+(H2O)n conformers have been performed up to n = 4, enabling binding energies of water to be derived. These decrease smoothly with n, consistent with the general trend of increasing metastable H2O loss in the experimental data. The lowest-energy conformers of T+(H2O)3 and T+(H2O)4 feature intermolecular bonding via charge-dipole interactions, in contrast with the purely hydrogen-bonded neutrals. We found no evidence for a closed hydration shell at n = 4, also contrasting with studies of neutral clusters

Current constraints on Cosmological Parameters from Microwave Background Anisotropies

We compare the latest observations of Cosmic Microwave Background (CMB) Anisotropies with the theoretical predictions of the standard scenario of structure formation. Assuming a primordial power spectrum of adiabatic perturbations we found that the total energy density is constrained to be $\Omega_{tot}=1.03\pm0.06$ while the energy density in baryon and Cold Dark Matter (CDM) are $\Omega_bh^2=0.021\pm0.003$ and $\Omega_{cdm}h^2=0.12\pm0.02$, (all at 68% C.L.) respectively. The primordial spectrum is consistent with scale invariance, ($n_s=0.97\pm0.04$) and the age of the universe is $t_0=14.6\pm0.9$ Gyrs. Adding informations from Large Scale Structure and Supernovae, we found a strong evidence for a cosmological constant $\Omega_{\Lambda}=0.70_{-0.05}^{+0.07}$ and a value of the Hubble parameter $h=0.69\pm0.07$. Restricting this combined analysis to flat universes, we put constraints on possible 'extensions' of the standard scenario. A gravity waves contribution to the quadrupole anisotropy is limited to be $r \le 0.42$ (95% c.l.). A constant equation of state for the dark energy component is bound to be $w_Q \le -0.74$ (95% c.l.). We constrain the effective relativistic degrees of freedom $N_\nu \leq 6.2$ and the neutrino chemical potential $-0.01 \leq \xi_e \leq 0.18$ and $|\xi_{\mu,\tau}|\leq 2.3$ (massless neutrinos).Comment: The status of cosmological parameters before WMAP. In press on Phys. Rev. D., Rapid Communication, 6 pages, 5 figure

Stringent Constraints on Cosmological Neutrino-Antineutrino Asymmetries from Synchronized Flavor Transformation

We assess a mechanism which can transform neutrino-antineutrino asymmetries between flavors in the early universe, and confirm that such transformation is unavoidable in the near bi-maximal framework emerging for the neutrino mixing matrix. We show that the process is a standard Mikheyev-Smirnov-Wolfenstein flavor transformation dictated by a synchronization of momentum states. We also show that flavor ``equilibration'' is a special feature of maximal mixing, and carefully examine new constraints placed on neutrino asymmetries. In particular, the big bang nucleosynthesis limit on electron neutrino degeneracy xi_e < 0.04 does not apply directly to all flavors, yet confirmation of the large-mixing-angle solution to the solar neutrino problem will eliminate the possibility of degenerate big bang nucleosynthesis.Comment: 11 pages, 6 figures; minor changes to match PRD versio