Delay Analysis of Graphene Field-Effect Transistors

In this letter, we analyze the carrier transit delay in graphene field-effect transistors (GFETs). GFETs are fabricated at the wafer-scale on sapphire substrate. For a device with a gate length of 210 nm, a current gain cut-off frequency fT of 18 GHz and 22 GHz is obtained before and after de-embedding. The extraction of the internal (Cgs,i, Cgd,i) and external capacitances (Cgs,ex and Cgd,ex) from the scaling behavior of the gate capacitances Cgs and Cgd allows the intrinsic ({\tau}_int), extrinsic ({\tau}_ext) and parasitic delays ({\tau}_par) to be obtained. In addition, the extraction of the intrinsic delay provides a new way to directly estimate carrier velocity from the experimental data while the breakdown of the total delay into intrinsic, extrinsic, and parasitic components can offer valuable information for optimizing RF GFETs structures.Comment: 3 pages, 3 figures, accepted for publication in IEEE Electron Device Letter

Concomitant Laparoendoscopic Single-Site Surgery for Vesicolithotomy and Finger-Assisted Single-Port Transvesical Enucleation of the Prostate

Transurethral resection of the prostate is the most common surgery for benign prostatic hyperplasia. However, it doesn't work best for men with very large prostate and bladder stones. Herein we report our initial experience with concomitant laparoendoscopic single-site surgery and finger-assisted single-port transvesical enucleation of the prostate for the treatment of the condition

Co-Adjusting Voltage/Frequency State and Interrupt Rate for Improving Energy-Efficiency of Latency-Critical Applications

As the power/energy consumption is one of the major contributors to the Total Cost of Ownership (TCO), improving power/energy efficiency is crucial for large-scale data centers where latency-critical applications are commonly accommodated while computing resources are usually under-utilized. For improving the power/energy efficiency of processors, most of the commercial processors support Dynamic Voltage and Frequency Scaling (DVFS) technology that enables to adjust Voltage and Frequency state (V/F state) of the processor dynamically. In particular, for the latency-critical applications, many prior studies propose power management policies using the DVFS for the latency-critical applications, which minimizes the performance degradation or satisfies the Service Level Objectives (SLOs) constraints. Meanwhile, although the interrupt rate also affects the response latency and energy efficiency of latency-critical applications considerably, those prior studies just introduce policies for V/F state adjustment while not considering the interrupt rate. Therefore, in this article, we investigate the impact of adjusting the interrupt rate on the tail response latency and energy consumption. Through our experimental results, we observe that adjusting interrupt rate along with V/F state management varies the performance and energy consumption considerably, and provides an opportunity to reduce energy further by showing latency overlap between different V/F states. Based on the observation, we show the quantitative potential in improving energy efficiency of co-adjusting V/F state and interrupt rate with a simple management policy, called Co-PI. Co-PI searches the most energy-efficient combination of the V/F state and interrupt rate from the latency and energy tables that we obtain through offline profiling, and reflect the combination to the core and NIC. Co-PI reduces energy consumption by 34.1% and 25.1% compared with performance and ondemand governors while showing the almost same tail response latency with the performance governor that operates cores at the highest V/F state statically. © 1991 BMJ Publishing Group. All rights reserved.1

DHP-Derivative and Low Oxygen Tension Effectively Induces Human Adipose Stromal Cell Reprogramming

BACKGROUND AND METHODS: In this study, we utilized a combination of low oxygen tension and a novel anti-oxidant, 4-(3,4-dihydroxy-phenyl)-derivative (DHP-d) to directly induce adipose tissue stromal cells (ATSC) to de-differentiate into more primitive stem cells. De-differentiated ATSCs was overexpress stemness genes, Rex-1, Oct-4, Sox-2, and Nanog. Additionally, demethylation of the regulatory regions of Rex-1, stemnesses, and HIF1alpha and scavenging of reactive oxygen species were finally resulted in an improved stem cell behavior of de-differentiate ATSC (de-ATSC). Proliferation activity of ATSCs after dedifferentiation was induced by REX1, Oct4, and JAK/STAT3 directly or indirectly. De-ATSCs showed increased migration activity that mediated by P38/JUNK and ERK phosphorylation. Moreover, regenerative efficacy of de-ATSC engrafted spinal cord-injured rats and chemical-induced diabetes animals were significantly restored their functions. CONCLUSIONS/SIGNIFICANCE: Our stem cell remodeling system may provide a good model which would provide insight into the molecular mechanisms underlying ATSC proliferation and transdifferentiation. Also, these multipotent stem cells can be harvested may provide us with a valuable reservoir of primitive and autologous stem cells for use in a broad spectrum of regenerative cell-based disease therapy

Predictive Markers for Screening Renal Damage in Children with Urinary Tract infections and Vesicoureteral Reflux

Purpose Urinary tract infections (UTIs) are the most common and serious bacterial infections in children. Therefore, early diagnosis of vesicoureteral reflux (VUR) for treatment planning and the identification of noninvasive markers that can predict renal injury are important in patients with UTIs. We analyzed the clinical features of pediatric UTIs commonly encountered by general practitioners and reinterpreted the blood tests and imaging findings to identify the important clinical predictive markers of VUR in order to selectively perform VCUG. Methods This retrospective study was performed among 183 children diagnosed with a UTI or acute pyelonephritis. Results The most significant predictor of high grade and bilateral VUR identified using area under the curve analyses was hydronephrosis on kidney ultrasound images with renal cortical defects on dimercaptosuccinic acid (DMSA) kidney scan simultaneously, followed by hydronephrosis only on kidney ultrasound. Conclusion The presence of hydronephrosis on kidney ultrasound images or cortical defects or asymmetric kidneys on the DMSA kidney scans can be predictive markers of VUR, reducing the need for VCUG. Our study can thus help minimize the exposure to radiation among patients through selective VCUG

Glutaric Aciduria Type 1 in Korea: Report of Two Novel Mutations

Glutaric aciduria type I (GA I) is an autosomal recessive disorder caused by a deficiency of glutaryl-CoA dehydrogenase. Although over 400 patients confirmed as GA I have been reported, reports from the Asian population had contributed to the minor proportion. We recently diagnosed two cases of GA I confirmed with mutational analysis. Here, we present their rather atypical clinical presentations with genetic characteristics for the first time in Korea. Profound developmental delay from birth, association of hearing loss, and neurological improvement after surgical intervention, were considered to be different clinical features from most reported cases. One patient was a compound heterozygote for p.Ser139Leu and p.Asp220Tyr, and the other for p.Ser139Leu and Glu160X. The mutations of the two alleles (p.Asp220Tyr and p.Glu160X) were novel and reports of p.Ser139Leu were rare both in Western and other Asian populations. These might suggest different genetic spectrum of Korean GA I patients