Massive and Red Objects predicted by a semianalytical model of galaxy formation

We study whether hierarchical galaxy formation in a concordance $\Lambda$CDM universe can produce enough massive and red galaxies compared to the observations. We implement a semi-analytical model in which the central black holes gain their mass during major mergers of galaxies and the energy feedback from active galaxy nuclei (AGN) suppresses the gas cooling in their host halos. The energy feedback from AGN acts effectively only in massive galaxies when supermassive black holes have been formed in the central bulges. Compared with previous models without black hole formation, our model predicts more massive and luminous galaxies at high redshift, agreeing with the observations of K20 up to $z\sim 3$. Also the predicted stellar mass density from massive galaxies agrees with the observations of GDDS. Because of the energy feedback from AGN, the formation of new stars is stopped in massive galaxies with the termination of gas cooling and these galaxies soon become red with color $R-K>$5 (Vega magnitude), comparable to the Extremely Red Objects (EROs) observed at redshift $z\sim$1-2. Still the predicted number density of very EROs is lower than observed at $z\sim 2$, and it may be related to inadequate descriptions of dust extinction, star formation history and AGN feedback in those luminous galaxies.Comment: Accepted for Publication in ApJ, added reference

A simplified method for analysis of polyunsaturated fatty acids

BACKGROUND: Analysis of fatty acid composition of biological materials is a common task in lipid research. Conventionally, preparation of samples for fatty acid analysis by gas chromatography involves two separate procedures: lipid extraction and methylation. This conventional method is complicated, tedious and time consuming. Development of a rapid and simple method for lipid analysis is warranted. RESULTS: We simplified the conventional method by combining the extraction and methylation into a single step (omitting the procedure of prior extraction). Various biological samples including cultured cells, animal tissues and human specimens have been tested using the new method. Statistical analysis indicates that the recovery of long chain fatty acids from tissue samples by the simplified method is significantly higher than that by the traditional method, but there is no difference in relative fatty acid composition between the two methods. This simplified method can significantly save time and materials, and reduce the potentials of sample loss and contamination. CONCLUSION: The lipid extraction procedure prior to methylation employed conventionally in lipid analysis can be omitted without affecting the recovery of long chain (≥ 18 C) fatty acids and their composition. The simplified method is rapid, easy-to-use, suitable for analysis of total long chain polyunsaturated fatty acid contents (e.g. n-6 and n-3 fatty acids) in various biological samples, especially when the number of samples to be analyzed is large and/or the specimen size is small

Is the Number of Giant Arcs in LCDM Consistent With Observations?

We use high-resolution N-body simulations to study the galaxy-cluster cross-sections and the abundance of giant arcs in the $\Lambda$CDM model. Clusters are selected from the simulations using the friends-of-friends method, and their cross-sections for forming giant arcs are analyzed. The background sources are assumed to follow a uniform ellipticity distribution from 0 to 0.5 and to have an area identical to a circular source with diameter 1\arcsec. We find that the optical depth scales as the source redshift approximately as \tau_{1''} = 2.25 \times 10^{-6}/[1+(\zs/3.14)^{-3.42}] (0.6<\zs<7). The amplitude is about 50% higher for an effective source diameter of 0.5\arcsec. The optimal lens redshift for giant arcs with the length-to-width ratio ($L/W$) larger than 10 increases from 0.3 for \zs=1, to 0.5 for \zs=2, and to 0.7-0.8 for \zs>3. The optical depth is sensitive to the source redshift, in qualitative agreement with Wambsganss et al. (2004). However, our overall optical depth appears to be only $\sim$ 10% to 70% of those from previous studies. The differences can be mostly explained by different power spectrum normalizations ($\sigma_8$) used and different ways of determining the $L/W$ ratio. Finite source size and ellipticity have modest effects on the optical depth. We also found that the number of highly magnified (with magnification $|\mu|>10$) and ``undistorted'' images (with $L/W<3$) is comparable to the number of giant arcs with $|\mu|>10$ and $L/W>10$. We conclude that our predicted rate of giant arcs may be lower than the observed rate, although the precise `discrepancy' is still unclear due to uncertainties both in theory and observations.Comment: Revised version after the referee's reports (32 pages,13figures). The paper has been significantly revised with many additions. The new version includes more detailed comparisons with previous studies, including the effects of source size and ellipticity. New discussions about the redshift distribution of lensing clusters and the width of giant arcs have been adde

Down-regulation of the M6P/IGF-II receptor increases cell proliferation and reduces apoptosis in neonatal rat cardiac myocytes

BACKGROUND: The mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) is a multi-functional protein that has been implicated in regulation of cell growth and apoptosis. Cardiac myocytes express relatively high levels of M6P/IGF2R, and cardiomyocyte apoptosis has been identified in a variety of cardiovascular disorders, such as myocardial infarction and heart failure. However, involvement of M6P/IGF2R in the pathogenesis of these conditions has not been determined. Thus, the objective of this study was to determine the role of M6P/IGF2R in regulation of cardiac myocyte growth and apoptosis. RESULTS: We down-regulated the expression of M6P/IGF2R in neonatal rat cardiac myocytes and examined the effect on cell proliferation and apoptosis. Infection of neonatal cardiomyocytes with an adenovirus expressing a ribozyme targeted against the M6P/IGF2R significantly reduced the level of M6P/IGF2R mRNA, as determined by RT-PCR and Ribonuclease Protection Assay (RPA). M6P-containing protein binding and endocytosis as well as the M6P/IGF2R-mediated internalization of (125)I-IGF-II were lower in the ribozyme-treated cells than the control myocytes, indicating that the number of functional M6P/IGF2R in the ribozyme treated cells was reduced. Accordingly, a marked increase in cell proliferation and a reduced cell susceptibility to hypoxia- and TNF-induced apoptosis were observed in the ribozyme-treated cells. CONCLUSIONS: These findings suggest that M6P/IGF2R may play a role in regulation of cardiac myocyte growth and apoptosis. Down regulation of this gene in cardiac tissues might be a new approach to prevention of cell death or promotion of mitogenesis for certain heart diseases

Development and Production of Omega-3 Fatty Acids-Enriched Foods is an Important Dietary Strategy to Improve People᾽s Nutritional and Health Status

Both Omega-6 and Omega-3 fatty acids are essential nutrients important for cellular structure and function but cannot be synthesized by the human body and must be obtained from food. These two classes of fatty acids are metabolically and functionally different and antagonistically regulate many physiological and pathological processes. Thus, the relative balance between Omega-6 and Omega-3 fatty acids are critical for good health. However, today’s diet contains too much Omega-6 but too little Omega-3, leading to a severe imbalance with a very high Omega-6/Omega-3 ratio (>10) in most people. Many lines of evidence suggest that this imbalance is a key factor contributing to the development of modern chronic diseases. A growing number of studies ranging from laboratory research to clinical trials have shown that balancing the tissue ratio of Omega-6/Omega-3 fatty acids by increasing tissue levels of Omega-3 fatty acids and/or decreasing the content of Omega-6 fatty acids are very beneficial for the prevention and treatment of many life-threating chronic diseases as well as for health promotion of the general public. Therefore, development and production of foods rich in Omega-3-fatty acids should be considered as a key health program to balance essential fat intake and thereby improve the nutritional and health status of all people

Variations of multi-parameter observations in atmosphere related to earthquake

Anomalies of multi-parameters (outgoing longwave radiation, surface latent heat flux, air temperature, relative humidity, and air pressure) before the 12 May 2008 Wenchuan &lt;i&gt;M&lt;/i&gt;&lt;sub&gt;s&lt;/sub&gt; =8.0 earthquake were discussed in order to obtain the seismic precursors. Multi-parameter data were computed based on multi-year background data. The results indicated that these parameters had significant variations prior to this event. The anomaly of outgoing longwave radiation was observed firstly, which gives an early warning. Next were air temperature, relative humidity, and air pressure, which had quasi-simultaneous variations in the basin and the mountain region close to the epicenter. The last was surface latent heat flux, which happened the day before this event. The characteristics of the parameter variations for this event are similar to other earthquakes, which is demonstrated in some other publications. The variations can be attributed to solid earth degassing and chemical reactions in the atmosphere. Additionally, the emission of gases from solid earth into the atmosphere could be ascribed to the tectonic stress of the Wenchuan earthquake

The iFat1 transgene permits conditional endogenous n-3 PUFA enrichment both in vitro and in vivo

Fat-1 transgenic mice, which endogenously convert n-6 PUFA to n-3 PUFA, are a useful tool in health research; however with this model timing of n-3 PUFA enrichment cannot be directly controlled. To add such capability, the novel Cre-recombinase inducible fat-1 (iFat1) transgenic mouse has been developed. The aim of this study was to characterize the utility of the iFat1 transgene as a model of Cre-inducible endogenous n-3 PUFA enrichment. Functionality of the iFat1 transgene was screened both in vitro and in vivo. In the presence of Cre, the iFat1 transgene resulted in a balancing (p < 0.01) of the n-6/n-3 PUFA ratio within phospholipids in the human embryonic kidney 293T cell line. For in vivo analysis, iFat1 transgenic mice were crossed with the R26-Cre-ERT2 (Tam-Cre) mouse line, a tamoxifen inducible Cre-expression model. Tam-Cre/iFat1 double hybrids were transiently treated with tamoxifen at 6–7 weeks, then terminated 3 weeks later. Tamoxifen treated mice had increased (p < 0.05) tissue n-3 PUFA and ≥two-fold reduction (p < 0.05) in the n-6/n-3 PUFA ratio of liver, kidney and muscle phospholipids relative to vehicle treated controls. Collectively these findings suggest that the iFat1 transgenic mouse may be a promising tool to help elucidate the temporal effects through which n-3 PUFA impacts health related outcomes

The Alignment between Satellites and Central Galaxies: Theory vs. Observations

Recent studies have shown that the distribution of satellite galaxies is preferentially aligned with the major axis of their central galaxy. The strength of this alignment has been found to depend strongly on the colours of the satellite and central galaxies, and only weakly on the mass of the halo in which the galaxies reside. In this paper we study whether these alignment signals, and their dependence on galaxy and halo properties, can be reproduced in a hierarchical structure formation model of a $\Lambda$CDM concordance cosmology. To that extent we use a large $N$-body simulation which we populate with galaxies following a semi-analytical model for galaxy formation. We find that if the orientation of the central galaxy is perfectly aligned with that of its dark matter halo, then the predicted central-satellite alignment signal is much stronger than observed. If, however, the minor axis of a central galaxy is perfectly aligned with the angular momentum vector of its dark matter halo, we can accurately reproduce the observed alignment strength as function of halo mass and galaxy color. Although this suggests that the orientation of central galaxies is governed by the angular momentum of their dark matter haloes, we emphasize that any other scenario in which the minor axes of central galaxy and halo are misaligned by $\sim 40^{\circ}$ (on average) will match the data equally well. Finally, we show that dependence of the alignment strength on the color of the central galaxy is most likely an artefact due to interlopers in the group catalogue. The dependence on the color of the satellite galaxies, on the other hand, is real and owes to the fact that red satellites are associated with subhaloes that were more massive at their time of accretion.Comment: 13 Pages, 10 Figures, one figure replaced. added in discussion about comparison with others results, Updated version to match accepted version to MNRA