Geometric Origin of CP Violation in an Extra-Dimensional Brane World

The fermion mass hierarchy and finding a predictive mechanism of the flavor mixing parameters remain two of the least understood puzzles facing particle physics today. In this work, we demonstrate how the realization of the Dirac algebra in the presence of two extra spatial dimensions leads to complex fermion field profiles in the extra dimensions. Dimensionally reducing to four dimensions leads to complex quark mass matrices in such a fashion that CP violation necessarily follows. We also present the generalization of the Randall-Sundrum scenario to the case of a multi-brane, six-dimensional brane-world and discuss how multi-brane worlds may shed light on the generation index of the SM matter content.Comment: 24 pages, 1 figure; references adde

Stem Mechanical Strength in Thinned versus Non-thinned Ceanothus spinosus, KSP

What effect does the thinning of chaparral around building structures have on plant health? More specifically, does the thinning of Ceanothus spinosus influence mechanical strength? The ability of our native chaparral to withstand environmental factors, such as the Santa Ana winds, and overall health is directly related to plant strength. Seeking to answer these questions, we hypothesized that a difference in water potential between thinned and non-thinned chaparral affects the stem mechanical strength of the plants.We believed that thinned C. spinosus due to greater hydration will be mechanically stronger than non-thinned chaparral.The knowledge of what helps chaparral to be stronger and healthier can be used to further the understanding of plant survival after a wildfire.We collected C. spinosus from thinned and non-thinned areas on Drescher campus at Pepperdine University and brought them back to the lab to measure the stem mechanical strength using the Instron and the Scholander-Hammel Pressure Chamber.After performing our research on the C. spinosus, we found that, although our data reflected higher mechanical strength in the thinned chaparral, the difference was not significant enough to support our hypothesis

Higgs Boson Bounds in Three and Four Generation Scenarios

In light of recent experimental results, we present updated bounds on the lightest Higgs boson mass in the Standard Model (SM) and in the Minimal Supersymmetric extension of the Standard Model (MSSM). The vacuum stability lower bound on the pure SM Higgs boson mass when the SM is taken to be valid up to the Planck scale lies above the MSSM lightest Higgs boson mass upper bound for a large amount of SUSY parameter space. If the lightest Higgs boson is detected with a mass M_{H} < 134 GeV (150 GeV) for a top quark mass M_{top} = 172 GeV (179 GeV), it may indicate the existence of a fourth generation of fermions. The region of inconsistency is removed and the MSSM is salvagable for such values of M_{H} if one postulates the existence of a fourth generation of leptons and quarks with isodoublet degenerate masses M_{L} and M_{Q} such that 60 GeV 170 GeV.Comment: 7 pages, 4 figures. To be published in Physical Review

Trustworthiness-Driven Graph Convolutional Networks for Signed Network Embedding

The problem of representing nodes in a signed network as low-dimensional vectors, known as signed network embedding (SNE), has garnered considerable attention in recent years. While several SNE methods based on graph convolutional networks (GCN) have been proposed for this problem, we point out that they significantly rely on the assumption that the decades-old balance theory always holds in the real-world. To address this limitation, we propose a novel GCN-based SNE approach, named as TrustSGCN, which corrects for incorrect embedding propagation in GCN by utilizing the trustworthiness on edge signs for high-order relationships inferred by the balance theory. The proposed approach consists of three modules: (M1) generation of each node's extended ego-network; (M2) measurement of trustworthiness on edge signs; and (M3) trustworthiness-aware propagation of embeddings. Furthermore, TrustSGCN learns the node embeddings by leveraging two well-known societal theories, i.e., balance and status. The experiments on four real-world signed network datasets demonstrate that TrustSGCN consistently outperforms five state-of-the-art GCN-based SNE methods. The code is available at https://github.com/kmj0792/TrustSGCN.Comment: 12 pages, 8 figures, 9 table

Enhanced mitochondrial superoxide scavenging does not Improve muscle insulin action in the high fat-fed mouse

Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2(tg) mice) and/or transgenically expressing catalase within the mitochondrial matrix (mcat(tg) mice) have increased scavenging of O2(˙-) and H2O2, respectively. Furthermore, muscle insulin action is partially preserved in high fat (HF)-fed mcat(tg) mice. The goal of the current study was to test the hypothesis that increased O2(˙-) scavenging alone or in combination with increased H2O2 scavenging (mtAO mice) enhances in vivo muscle insulin action in the HF-fed mouse. Insulin action was examined in conscious, unrestrained and unstressed wild type (WT), sod2(tg), mcat(tg) and mtAO mice using hyperinsulinemic-euglycemic clamps (insulin clamps) combined with radioactive glucose tracers following sixteen weeks of normal chow or HF (60% calories from fat) feeding. Glucose infusion rates, whole body glucose disappearance, and muscle glucose uptake during the insulin clamp were similar in chow- and HF-fed WT and sod2(tg) mice. Consistent with our previous work, HF-fed mcat(tg) mice had improved muscle insulin action, however, an additive effect was not seen in mtAO mice. Insulin-stimulated Akt phosphorylation in muscle from clamped mice was consistent with glucose flux measurements. These results demonstrate that increased O2(˙-) scavenging does not improve muscle insulin action in the HF-fed mouse alone or when coupled to increased H2O2 scavenging

Generation of cloned transgenic pigs rich in omega-3 fatty acids

Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001). © 2006 Nature Publishing Group

Humanized cereblon mice reveal two distinct pathways of immunomodulatory drugs

Immunomodulatory drugs (IMiDs), including thalidomide derivatives such as lenalidomide and pomalidomide, offer therapeutic benefit in several hematopoietic malignancies and autoimmune/inflammatory diseases. However, it is difficult to study the IMiD mechanism of action in murine disease models because murine cereblon (CRBN), the substrate receptor for IMiD action, is resistant to some of IMiDs therapeutic effects. To overcome this difficulty, we generated humanized cereblon (CRBNI391V) mice thereby providing an animal model to unravel complex mechanisms of action in a murine physiological setup. In our current study, we investigated the degradative effect toward IKZF1 and CK-1α, a target substrate of IMiDs. Unlike WT mice which were resistant to lenalidomide and pomalidomide, T lymphocytes from CRBNI391V mice responded with a higher degree of IKZF1 and CK-1α protein degradation. Furthermore, IMiDs resulted in an increase in IL-2 among CRBNI391V mice but not in the WT group. We have also tested a thalidomide derivative, FPFT-2216, which showed an inhibitory effect toward IKZF1 protein level. As opposed to pomalidomide, FPFT-2216 and lenalidomide degrades CK-1α. Additionally, we assessed the potential therapeutic effects of IMiDs in dextran sodium sulfate (DSS)-induced colitis. In both WT and humanized mice, lenalidomide showed a significant therapeutic effect in the DSS model of colitis, while the effect of pomalidomide was less pronounced. Thus, while IMiDs’ degradative effect on IKZF1 and CK-1α, and up-regulation of IL-2, is dependent on CRBN, the therapeutic benefit of IMiDs in a mouse model of inflammatory bowel disease occurs through a CRBN–IMiD binding region independent pathway

Shear stress regulation of miR-93 and miR-484 maturation through nucleolin.

Pulsatile shear (PS) and oscillatory shear (OS) elicit distinct mechanotransduction signals that maintain endothelial homeostasis or induce endothelial dysfunction, respectively. A subset of microRNAs (miRs) in vascular endothelial cells (ECs) are differentially regulated by PS and OS, but the regulation of the miR processing and its implications in EC biology by shear stress are poorly understood. From a systematic in silico analysis for RNA binding proteins that regulate miR processing, we found that nucleolin (NCL) is a major regulator of miR processing in response to OS and essential for the maturation of miR-93 and miR-484 that target mRNAs encoding Krüppel-like factor 2 (KLF2) and endothelial nitric oxide synthase (eNOS). Additionally, anti-miR-93 and anti-miR-484 restore KLF2 and eNOS expression and NO bioavailability in ECs under OS. Analysis of posttranslational modifications of NCL identified that serine 328 (S328) phosphorylation by AMP-activated protein kinase (AMPK) was a major PS-activated event. AMPK phosphorylation of NCL sequesters it in the nucleus, thereby inhibiting miR-93 and miR-484 processing and their subsequent targeting of KLF2 and eNOS mRNA. Elevated levels of miR-93 and miR-484 were found in sera collected from individuals afflicted with coronary artery disease in two cohorts. These findings provide translational relevance of the AMPK-NCL-miR-93/miR-484 axis in miRNA processing in EC health and coronary artery disease

Inhomogeneous Neutrino Degeneracy and Big Bang Nucleosynthesis

We examine Big Bang nucleosynthesis (BBN) in the case of inhomogenous neutrino degeneracy, in the limit where the fluctuations are sufficiently small on large length scales that the present-day element abundances are homogeneous. We consider two representive cases: degeneracy of the electron neutrino alone, and equal chemical potentials for all three neutrinos. We use a linear programming method to constrain an arbitrary distribution of the chemical potentials. For the current set of (highly-restrictive) limits on the primordial element abundances, homogeneous neutrino degeneracy barely changes the allowed range of the baryon-to-photon ratio. Inhomogeneous degeneracy allows for little change in the lower bound on the baryon-to-photon ratio, but the upper bound in this case can be as large as 1.1 \times 10^{-8} (only electron neutrino degeneracy) or 1.0 \times 10^{-9} (equal degeneracies for all three neutrinos). For the case of inhomogeneous neutrino degeneracy, we show that there is no BBN upper bound on the neutrino energy density, which is bounded in this case only by limits from structure formation and the cosmic microwave background.Comment: 6 pages, no figure

Bisphenol A exposure in Mexico City and risk of prematurity: a pilot nested case control study

Abstract Background Presence of Bisphenol A (BPA) has been documented worldwide in a variety of human biological samples. There is growing evidence that low level BPA exposure may impact placental tissue development and thyroid function in humans. The aim of this present pilot study was to determine urinary concentrations of BPA during the last trimester of pregnancy among a small subset of women in Mexico City, Mexico and relate these concentrations to risk of delivering prematurely. Methods A nested case-control subset of 60 participants in the Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) study in Mexico City, Mexico were selected based on delivering less than or equal to 37 weeks of gestation and greater than 37 weeks of gestation. Third trimester archived spot urine samples were analyzed by online solid phase extraction coupled with high performance liquid chromatography isotope dilution tandem mass spectrometry. Results BPA was detected in 80.0% (N = 48) of the urine samples; total concentrations ranged from &lt; 0.4 &#956;g/L to 6.7 &#956;g/L; uncorrected geometric mean was 1.52 &#956;g/L. The adjusted odds ratio of delivering less than or equal to 37 weeks in relation to specific gravity adjusted third trimester BPA concentration was 1.91 (95%CI 0.93, 3.91, p-value = 0.08). When cases were further restricted to births occurring prior to the 37th week (n = 12), the odds ratio for specific-gravity adjusted BPA was larger and statistically significant (p &lt; 0.05). Conclusions This is the first study to document measurable levels of BPA in the urine of a population of Mexican women. This study also provides preliminary evidence, based on a single spot urine sample collected during the third trimester, that pregnant women who delivered less than or equal to 37 weeks of gestation and prematurely (&lt; 37 weeks) had higher urinary concentrations of BPA compared to women delivering after 37 weeks.http://deepblue.lib.umich.edu/bitstream/2027.42/78251/1/1476-069X-9-62.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78251/2/1476-069X-9-62.pdfPeer Reviewe