Metaplastic Carcinoma of the Left Breast with Extensive Chondroid Differentiation

Metaplastic breast carcinoma is very rare neoplasm which contains mixture of carcinomatous (epithelial) and sarcomatous (mesenchymal) elements in variable proportion. Metaplastic carcinoma with chondroid differentiation is even rarer. We report a case of metaplastic carcinoma with extensive chondroid differentiation as there is paucity of information regarding pathological features and clinical outcomes for these rare tumors. Tumor had characteristic definite areas of classic infiltrating duct carcinoma with abundant chondromyxoid matrix, focal areas of chondrosarcoma and cartilagenous metaplasia. Tumour cells were immunoreactive for S-100, ER, and PR. When pathologist encounter breast tumor with chondroid differentiation, careful gross sampling, histopathology and immunoreactivity for mesenchymal and epithelial component are most useful to differentiate metaplastic carcinoma from malignant phylloides tumors and malignant adenomyoepithelioma

Clinicopathological study of benign ovarian tumuors

Background: The incidence of ovarian tumor amongst gynecological admissions have been reported to vary from 1-3 %. About 75% of these tumors have been found to be benign. Ovarian malignancies represent the greatest clinical challenge of all the gynecological malignancies. During the reproductive years most of the ovarian tumors encountered are benign. About 2/3 of the ovarian tumors are encountered in this group only. The chance that an ovarian tumor is malignant in a patient younger than 45 years is 1 in 15. The differentiation of the benign from malignant tumors can go wrong even with imaging modalities.CA125 along with ultrasound are useful in differentiating benign from malignant tumors. Histopathological examination is gold standard for diagnosis of ovarian neoplasm.Methods: The present study includes consecutive cases of histopathologically proven ovarian tumors of 3 years from June 2010 to May 2013 reported by the Department of Pathology of our tertiary care center. It includes total 150 cases. After careful study of gross findings, appropriate bits were taken from received ovarian specimen, followed by routine paraffin processing to make H and E stained slides. Special stains were used wherever needed.Results: Majority of the cases 91 (60.67%) were benign, 53 (35.33%) were malignant and 6 (4.0%) were borderline. Surface epithelial tumours were the most common type (68.13%) of ovarian neoplasm in this study. Most of tumours in our study occurred in the age group of 21-40 years. Mucinous cystadenomas were most common benign surface epithelial tumour and most common benign tumors overall. There were 22 cases of benign germ cell tumor, all were mature teratoma. All the sex-cord stromal tumours were diagnosed in women older than 40 years. Most common benign lesion in our study is surface epithelial tumour and in age group of 21-40 years. 84% patients studied had symptoms at presentation, out of which 26% of patient presented with dull/dragging pain. Pan hysterectomy was the most common procedure for surgical management.Conclusions: Most of ovarian neoplasm are benign with mucinous cystadenoma being commonest entity. Commonest age group is 21-40 years. Commonest benign germ cell tumor is Mature cystic teratoma. Commonest clinical symptom is dull/dragging pain. Pan hysterectomy was the most common procedure for surgical management.

Association of Genetic Variants in XPC and XPG Genes with Cervical Cancer Risk in a Rural Population: A Hospital Based Case Control Study

Background: Cervical cancer is a major concern of health risk in urban and rural parts of India.. Aim and Objectives: This study was aimed to find out frequency of polymorphisms in DNA repair genes including Xeroderma pigmentosum complementation group C (XPC) and Xenoderma pigmentosum complementation group G (XPG) in patients of cervical cancer from Maharashtra and to evaluate their association with risk of cervical cancer. Materials and Methods: We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to examine gene polymorphisms in 350 patients with cancer of cervix and 400 age and sex matched normal controls. Results: The results obtained indicated that there was no significant difference in the genotype distribution between cervical cancer patients and controls for XPC Lys939Gln, -371promoter and XPG His 1104 Asp. The result showed that genotype frequencies of XPC Val 499 Arg of codon 499 in exon 15 (OR=4.26; 95% CI=(3.007-6.03); p= <0.0001) were increased significantly. Conclusion: This study indicates that polymorphisms in Val499Arg haplotype of XPC gene appear to influence genetic susceptibility of individual to cervical cancer in Maharashtrian patients