10-kJ PW Laser for the FIREX-I Program

A 10-kJ PW laser (LFEX) is under construction for the FIREX-I program. This paper reports a design overview of LFEX, the technological development of a large-aperture arrayed amplifier with modified four-pass architecture, wavefront correction, a large-aperture Faraday rotator with a superconducting magnet, a new pulse compressor arrangement, and focus control

Stem cell factor and its soluble receptor (c-kit) in serum of asthmatic patients- correlation with disease severity

<p>Abstract</p> <p>Background</p> <p>SCF (stem cell factor) is a pleiotropic cytokine exerting its role at different stages of bone marrow development and affecting eosinophil activation, mast cells and basophil chemotaxis and survival. The aim of the study was to assess concentration of SCF and its soluble receptor c-kit (sc-kit) in peripheral blood of patients with asthma referring it to asthma severity and phenotype.</p> <p>Methods</p> <p>The study involved 107 patients with bronchial asthma, well characterized with respect to severity and 21 healthy controls. Concentration of SCF and sc-kit in the patients serum were measured by ELISA method.</p> <p>Results</p> <p>Mean serum SCF level in the group of asthmatics (n = 88) was significantly higher as compared to healthy controls (1010 pg/ml ± 37 vs 799 ± 33; p < 0,001). The level of SCF was higher in patients with severe asthma as compared to patients with non-severe asthma (1054 +/- 41 pg/ml vs 819 +/- 50; p < 0,01) and correlated with dose of inhaled glucocorticosteroids taken by the patients to achieve asthma control (R = 0,28; p < 0,01). The mean sc-kit serum level did not differ between asthmatic patients and healthy controls, however the level of sc-kit in non-severe asthmatics was significantly higher as compared to patients with severe asthma and healthy controls. In asthmatic patients (n = 63) the level of sc-kit correlated positively with FEV1% predicted value (R = 0,45; p < 0,001) and MEF25% predicted value (R = 0,33; p < 0,01). The level of sc-kit inversely correlated with the dose of inhaled glucocorticosteroids taken by the patients (R = -0,26; p < 0,01).</p> <p>Conclusion</p> <p>Serum levels of SCF and its soluble receptor c-kit seem to be reflect asthma severity suggesting a role for these molecules in asthmatic inflammation.</p

The HALNA project: Diode-pumped solid-state laser for inertial fusion energy

High-enery, rep.-rated, diode-pumped solid-state laser (DPSSL) is one of leading candidates for inertial fusion energy driver (IFE) and related laser-driven high-field applications. The project for the development of IFE laser driver in Japan, HALNA (High Average-power Laser for Nuclear Fusion Application) at ILE, Osaka University, aims to demonstrate 100-J pulse energy at 10 Hz rep. rate with 5 times diffraction limited beam quality. In this article, the advanced solid-state laser technologies for one half scale of HALNA (50 J, 10 Hz) are presented including thermally managed slab amplifier of Nd:phosphate glass and zig-zag optical geometry, and uniform, large-area diode-pumping

High-density compression experiments at ILE, Osaka

Direct-drive implosion experiments on the GEKKO XII laser (9 kJ, 0.5 μm, 2 ns) with deuterium and tritium (DT) exchanged plastic hollow shell targets demonstrated fuel areal densities (ρR) of approximately 0.1 g/cm2 and fuel densities of approximately 600 times liquid density at fuel temperatures of approximately 0.3 keV. (The density and ρR values refer only to DT and do not include carbons in the plastic targets.) These values are to be compared with thermonuclear ignition conditions, i.e., fuel densities of 500-1000 times liquid density, fuel areal densities greater than 0.3 g/cm2, and fuel temperatures greater than 5 keV. The irradiation nonuniformity in these experiments was significantly reduced to a level of &lt;5% in root mean square by introducing random-phase plates. The target irregularity was controlled to a 1% level. The fuel ρR was directly measured with the neutron activation of Si, which was originally compounded in the plastic targets. The fuel densities were estimated from the ρR values using the mass conservation relation, where the ablated mass was separately measured using the time-dependent X-ray emission from multilayer targets. Although the observed densities were in agreement with one-dimensional calculation results with convergence ratios of 25-30, the observed neutron yields were significantly lower than those of the calculations. This suggests the implosion uniformity is not sufficient to create a hot spark in which most neutrons should be generated