Theory of the Three-Group Evolutionary Minority Game

Based on the adiabatic theory for the evolutionary minority game (EMG) that we proposed earlier[1], we perform a detail analysis of the EMG limited to three groups of agents. We derive a formula for the critical point of the transition from segregation (into opposing groups) to clustering (towards cautious behaviors). Particular to the three-group EMG, the strategy switching in the "extreme" group does not occur at every losing step and is strongly intermittent. This leads to an correction to the critical value of the number of agents at the transition, $N_c$. Our expression for $N_c$ is in agreement with the results obtained from our numerical simulations.Comment: 4 pages and 2 figure

A comprehensive review of artificial intelligence for pharmacology research

With the innovation and advancement of artificial intelligence, more and moreartificial intelligence techniques are employed in drug research, biomedicalfrontier research, and clinical medicine practice, especially, in the field ofpharmacology research. Thus, this review focuses on the applications ofartificial intelligence in drug discovery, compound pharmacokinetic prediction,and clinical pharmacology. We briefly introduced the basic knowledge anddevelopment of artificial intelligence, presented a comprehensive review, and then summarized the latest studies and discussed the strengths and limitations of artificial intelligence models. Additionally, we highlighted several important studies and pointed out possible research directions

Supramolecular drug inclusion complex constructed from cucurbit[7]uril and the hepatitis B drug Adefovir

The interaction between cucuribit[7]uril (Q[7]) and Adefovir (ADV) has been studied in aqueous solution by 1H NMR spectroscopy, electronic absorption spectroscopy, Isothermal Titration Calorimetry and mass spectrometry. The results revealed that an inclusion complex was formed via encapsulation of the purine rings of the guest ADV, while the phosphonomethoxyethyl group was prevented from entering the cavity. ITC data revealed that the formation of this 1:1 inclusion complex is mainly driven by favourable enthalpy changes. Studies investigating the release of ADV from the inclusion complex revealed enhanced rates under acidic conditions, although the rates were slower than observed for the free guest under the same conditions. Thermal stability studies indicated that the included form of ADV was more stable that the free form

A hemicyanine and cucurbit[n]uril inclusion complex: competitive guest binding of cucurbit[7]uril and cucurbit[8]uril

The interaction between the hemicyanine indole derivative H and the cucubit[n]urils Q[7] and Q[8] has been studied using 1H NMR and UV spectroscopy as well as by fluorescence experiments. Competitive studies on the inclusion of H by Q[7] and Q[8] have also been conducted, and reveal that on changing the size of the Q[n] cavity, the binding behaviour can be very different