Access to Care for VA Dialysis Patients During Superstorm Sandy.

Introduction: This study examines the use of dialysis services by end-stage renal disease (ESRD) patients following the Superstorm Sandy-related, months-long closure of the New York campus of the US Department of Veterans Affairs (VA) New York Harbor VA Healthcare System (NYHHS, Manhattan VAMC). Methods: Outpatient visits, dialysis care, emergency department visits, and hospitalizations at VA and non-VA facilities for 47 Manhattan VAMC ESRD patients were examined 12 months pre- and post-Sandy using VA administrative and clinical data. Results: The Brooklyn campus of NYHHS, which is within ten miles of Manhattan VAMC, experienced the largest increase in the number of dialysis encounters after the closure. Dialysis encounters for VA patients also increased at non-VA facilities, rising on average, to 106 per month. For the James J Peters Bronx VAMC, the number of total dialysis encounters for Manhattan VAMC patients fluctuated between 39 and 43 per month, dropping to less than 30 after the Manhattan VAMC dialysis unit reopened. Conclusion: Manhattan VAMC ESRD patients used nearby alternate VA sites and non-VA clinics for their care during the closure of the Manhattan VAMC dialysis unit. The VA electronic health records played an important role in ensuring continuity of care for patients who exclusively used VAMC facilities post-Sandy because patient information was immediately accessible at other VA facilities. The events related to Superstorm Sandy highlight the need for dialysis providers to have a comprehensive disaster plan, including nearby alternate care sites that can increase service capacity when a dialysis facility is closed because of a disaster

Exact Algorithms and Lower Bounds for Stable Instances of Euclidean k-Means

We investigate the complexity of solving stable or perturbation-resilient instances of k-Means and k-Median clustering in fixed dimension Euclidean metrics (or more generally doubling metrics). The notion of stable or perturbation resilient instances was introduced by Bilu and Linial [2010] and Awasthi et al. [2012]. In our context we say a k-Means instance is \alpha-stable if there is a unique OPT solution which remains unchanged if distances are (non-uniformly) stretched by a factor of at most \alpha. Stable clustering instances have been studied to explain why heuristics such as Lloyd's algorithm perform well in practice. In this work we show that for any fixed \epsilon>0, (1+\epsilon)-stable instances of k-Means in doubling metrics can be solved in polynomial time. More precisely we show a natural multiswap local search algorithm in fact finds the OPT solution for (1+\epsilon)-stable instances of k-Means and k-Median in a polynomial number of iterations. We complement this result by showing that under a plausible PCP hypothesis this is essentially tight: that when the dimension d is part of the input, there is a fixed \epsilon_0>0 s.t. there is not even a PTAS for (1+\epsilon_0)-stable k-Means in R^d unless NP=RP. To do this, we consider a robust property of CSPs; call an instance stable if there is a unique optimum solution x^* and for any other solution x', the number of unsatisfied clauses is proportional to the Hamming distance between x^* and x'. Dinur et al. have already shown stable QSAT is hard to approximate for some constant Q, our hypothesis is simply that stable QSAT with bounded variable occurrence is also hard. Given this hypothesis, we consider "stability-preserving" reductions to prove our hardness for stable k-Means. Such reductions seem to be more fragile than standard L-reductions and may be of further use to demonstrate other stable optimization problems are hard.Comment: 29 page

Numerical/Experimental Studies on Performance at Low Engine Speeds:A Case study Downsized Iranian National Engine (EF7)

Engine downsizing is a trusted method to reduce fuel consumption and pollution emitted from internal combustion engines. In this method, engine displacement volume is reduced while maintaining the same power/torque characteristics. However, there still exist several limitations to utilize this technology. In this paper, the naturally aspirated type of Iran national engine (EF7-NA) is investigated for a possible downsized version. A one-dimensional engine model equipped with a zero-dimensional two-zone combustion sub-model was developed and validated via experimental results for both natural aspirated and turbocharged engine types. Then experimental and numerical studies were carried out for the primary concept, deactivation of one cylinder besides using a turbocharger. To overcome the concept shortages, especially in lower ranges of engine speed, numerical studies were extended. Deployment of several turbochargers with different performance maps and different valve timing via a dual CVVT system were investigated. The results showed that there is a feasible method for EF7 engine downsizing via a 3-cylinder type equipped with a modified turbocharger and valve timing. The maximum difference between base-engine and downsized version torque is about 7% in low engine speeds

Observations of Peak Strength Behavior in CSA Cement Mortars

The purpose of this study was to assess the mechanical property performance behavior of calcium sulfoaluminate (CSA) cement mortar when cured at ambient laboratory temperature of ~23°C (73°F) and constant 50% relative humidity for an extended period of time. Four CSA cement mortars were tested. Three CSA cement mortars contained equivalent mass amounts of calcium sulfate; whereas, the fourth mortar contained double the amount of calcium sulfate. The three CSA cement mortars containing constant mass amounts of calcium sulfate differed as the specific type of calcium sulfate varied across the three formulations—one mortar containing solely anhydrite, one mortar contained half anhydrite and half gypsum while the other mortar solely contained gypsum. The fourth mortar contained double the amount of calcium sulfate when compared with the others while having a 1/1 blend of anhydrite and gypsum. Specific mortars were either tested for direct tensile strength according to ASTM C307 or for compressive strength according to ASTM C109. All tested mortars displayed statistically significant strength loss trends versus time when cured at constant 50% relative humidity. Cement paste samples were analyzed with TGA/SDT and XRD in an effort to identify microstructure changes corresponding to observed strength loss. Cement paste analysis suggests strength loss within the tested CSA cement mortars occurred as a result of ettringite decomposition

Averting the legacy of kidney disease: focus on childhood

World Kidney Day 2016 focuses on kidney disease in childhood and the antecedents of adult kidney disease that can begin in earliest childhood. Chronic kidney disease (CKD) in childhood differs from that in adults, as the largest diagnostic group among children includes congenital anomalies and inherited disorders, with glomerulopathies and kidney disease in the setting of diabetes being relatively uncommon. In addition, many children with acute kidney injury will ultimately develop sequelae that may lead to hypertension and CKD in later childhood or in adult life. Children born early or who are small-for date newborns have relatively increased risk for the development of CKD later in life. Persons with a high-risk birth and early childhood history should be watched closely in order to help detect early signs of kidney disease in time to provide effective prevention or treatment. Successful therapy is feasible for advanced CKD in childhood; there is evidence that children fare better than adults, if they receive kidney replacement therapy including dialysis and transplantation, while only a minority of children may require this ultimate intervention Because there are disparities in access to care, effort is needed so that those children with kidney disease, wherever they live, may be treated effectively, irrespective of their geographic or economic circumstances. Our hope is that World Kidney Day will inform the general public, policy makers and caregivers about the needs and possibilities surrounding kidney disease in childhood

Treatment of Iron-deficiency Anemia in Patients with Subclinical Hypothyroidism

Subclinical hypothyroidism is a health state that is associated with hypercholesterolemia, infertility, iron-deficiency anemia, and poor obstetric outcome. This article summarizes the results of a prospective clinical investigation of whether treatment of subclinical hypothyroidism and iron-deficiency anemia with a combination of levothyroxine plus iron salt would be superior to each treatment alone

Averting the Legacy of Kidney Disease—Focus on Childhood

World Kidney Day 2016 focuses on kidney disease in childhood and the antecedents of adult kidney disease that can begin in earliest childhood. Chronic kidney disease (CKD) in childhood differs from that in adults, as the largest diagnostic group among children includes congenital anomalies and inherited disorders, with glomerulopathies and kidney disease in the setting of diabetes being relatively uncommon. In addition, many children with acute kidney injury will ultimately develop sequelae that may lead to hypertension and CKD in later childhood or in adult life. Children born early or who are small-for date newborns have relatively increased risk for the development of CKD later in life. Persons with a high-risk birth and early childhood history should be watched closely in order to help detect early signs of kidney disease in time to provide effective prevention or treatment. Successful therapy is feasible for advanced CKD in childhood; there is evidence that children fare better than adults, if they receive kidney replacement therapy including dialysis and transplantation, while only a minority of children may require this ultimate intervention Because there are disparities in access to care, effort is needed so that those children with kidney disease, wherever they live, may be treated effectively, irrespective of their geographic or economic circumstances. Our hope is that World Kidney Day will inform the general public, policy makers and caregivers about the needs and possibilities surrounding kidney disease in childhood

A Comparison between Recombinant Activated Factor VII (Aryoseven) and Novoseven in Patients with Congenital Factor VII Deficiency

In order to establish the efficacy and biosimilar nature of AryoSeven to NovoSeven in the treatment of congenital factor VII (FVII) deficiency, patients received either agent at 30 1/4g/kg, intravenously per week for 4 weeks, in a randomized fashion. The primary aim was to compare FVII:coagulation activity (FVII:C), 20 minutes after recombinant activated FVII (rFVIIa) injection, in the 2 groups. A secondary measure was self-reported bleeding. The median interquartile baseline range of the plasma level of activated FVII (FVIIa) activity in the 2 groups was 1.6 (1.1-14.0) IU/dL and 5.0 (1.1-25.5) IU/dL. All patients achieved levels of FVIIa (FVII:C) >30 IU/dL, 20 minutes after the injection of rFVIIa. Bleeding was similar between the 2 groups, with a comparable decrease in severity and frequency compared to the last month prior to treatment. AryoSeven is similar to NovoSeven in increasing postinjection FVIIa activity as well as in clinical safety and efficacy. © The Author(s) 2014

The College News, 1965-11-19, Vol. 52, No. 08

Bryn Mawr College student newspaper. Merged with The Haverford News in 1968 to form the Bi-college News (with various titles from 1968 on). Published weekly (except holidays) during the academic year

Erratum to: Averting the legacy of kidney disease: focus on childhood

World Kidney Day 2016 focuses on kidney disease in childhood and the antecedents of adult kidney disease that can begin in earliest childhood. Chronic kidney disease (CKD) in childhood differs from that in adults, as the largest diagnostic group among children includes congenital anomalies and inherited disorders, with glomerulopathies and kidney disease in the setting of diabetes being relatively uncommon. In addition, many children with acute kidney injury will ultimately develop sequelae that may lead to hypertension and CKD in later childhood or in adult life. Children born early or who are small-for date newborns have relatively increased risk for the development of CKD later in life. Persons with a high-risk birth and early childhood history should be watched closely in order to help detect early signs of kidney disease in time to provide effective prevention or treatment. Successful therapy is feasible for advanced CKD in childhood; there is evidence that children fare better than adults, if they receive kidney replacement therapy including dialysis and transplantation, while only a minority of children may require this ultimate intervention Because there are disparities in access to care, effort is needed so that those children with kidney disease, wherever they live, may be treated effectively, irrespective of their geographic or economic circumstances. Our hope is that World Kidney Day will inform the general public, policy makers and caregivers about the needs and possibilities surrounding kidney disease in childhood