Configuration of compounds screened against heparanase and their relationship to heparan sulfate polysaccharide backbone.

<p>Configuration of compounds screened against heparanase and their relationship to heparan sulfate polysaccharide backbone.</p

A proposed diversity oriented route to pseudodisaccharides.

<p>A proposed diversity oriented route to pseudodisaccharides.</p

A selection of biologically active pseudodisaccharides.

<p>A selection of biologically active pseudodisaccharides.</p

Molecules in the pseudosaccahride libraray, 8a-8d, 9a-9d and 10a-10d, and compound 11.

<p>Molecules in the pseudosaccahride libraray, 8a-8d, 9a-9d and 10a-10d, and compound 11.</p

Compound 19.

<p>Compound 19.</p

Rationale for the selectivity in the hydrogenation step for 18a-18d.

<p>Hydrogen is transferred from the surface of the catalyst to the least hindered face of the alkene shown by an arrow.</p

Preparation of compounds 8a-8d, 9a-9d and 10a-10d.

<p>Preparation of compounds 8a-8d, 9a-9d and 10a-10d.</p

A previously prepared focused library to probe the glycosyl hydrolase enzyme binding pocket.

<p>A previously prepared focused library to probe the glycosyl hydrolase enzyme binding pocket.</p

Mechanism of the hydrolysis by heparanase.

<p>(a) Role of Glu252 and Glu343 residues at the catalytic site (b) The interaction between the of amino substituent at the pseudoanomeric position and carboxyl residues.</p

Preparation of vinylsugars 12a, 12b and 12c.

<p>Preparation of vinylsugars 12a, 12b and 12c.</p