14 research outputs found
Discovery of highly spin-polarized conducting surface states in the strong spin-orbit coupling semiconductor SbSe
Majority of the AB type chalcogenide systems with strong spin-orbit
coupling, like BiSe, BiTe and SbTe etc., are
topological insulators. One important exception is SbSe, where a
topological non-trivial phase was argued to be possible under ambient
conditions, but such a phase could be detected to exist only under pressure. In
this Letter, we show that like BiSe, SbSe, displays generation
of highly spin-polarized current under mesoscopic superconducting point
contacts as measured by point contact Andreev reflection spectroscopy. In
addition, we observe a large negative and anisotropic magnetoresistance in
SbSe, when the field is rotated in the basal plane. However, unlike in
BiSe, in case of SbSe a prominent quasiparticle interference
(QPI) pattern around the defects could be obtained in STM conductance imaging.
Thus, our experiments indicate that SbSe is a regular band insulator
under ambient conditions, but due to it's high spin-orbit coupling, non-trivial
spin-texture exists on the surface and the system could be on the verge of a
topological insulator phase.Comment: 5 pages, 4 figures, supplemental material not include
Generation of strain-induced pseudo-magnetic field in a doped type-II Weyl semimetal
In Weyl semimetals, there is an intriguing possibility of realizing a
pseudo-magnetic field in presence of small strain due to certain special cases
of static deformations. This pseudo-magnetic field can be large enough to form
quantized Landau levels and thus become observable in Weyl semimetals. In this
paper, we experimentally show the emergence of a pseudo-magnetic field (~ 3
Tesla) by Scanning Tunneling Spectroscopy (STS) on the doped Weyl semimetal
Re-MoTe2, where distinct Landau level oscillations in the tunneling conductance
are clearly resolved. The crystal lattice is intrinsically strained where large
area STM imaging of the surface reveals differently strained domains where
atomic scale deformations exist forming topographic ripples with varying
periodicity in the real space. The effect of pseudo-magnetic field is clearly
resolved in areas under maximum strain.Comment: 6 pages, 4 figure
Design, Synthesis, Characterization, and Computational Studies on Benzamide Substituted Mannich Bases as Novel, Potential Antibacterial Agents
A series of benzamide substituted Mannich bases (1–7) were synthesized. The synthesized derivatives were authenticated by TLC, UV-Visible, FTIR, NMR, and mass spectroscopic techniques and further screened for in vitro antibacterial activity by test tube dilution method using amoxicillin and cefixime as standard drugs. The compounds 5, 6, and 7 were found to be the most active antibacterial agents among all the synthesized compounds. The physicochemical similarity of the compounds with standard drugs was assessed by calculating various physicochemical properties using software programs. The percent similarity of synthesized compounds was found to be good and compound 1 was found to have higher percentage of similarity. The compounds were subjected to QSAR by multilinear regression using Analyze it version 3.0 software, and four statistically sound models were developed with R2 (0.963–0.997), Radj2 (0.529–0.982), and Q2 (0.998–0.999) with good F (2.35–65.56) values
Mannich Bases: An Important Pharmacophore in Present Scenario
Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of aminoalkyl chain bearing Mannich bases like fluoxetine, atropine, ethacrynic acid, trihexyphenidyl, and so forth with high curative value. The literature studies enlighten the fact that Mannich bases are very reactive and recognized to possess potent diverse activities like anti-inflammatory, anticancer, antifilarial, antibacterial, antifungal, anticonvulsant, anthelmintic, antitubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. The biological activity of Mannich bases is mainly attributed to , -unsaturated ketone which can be generated by deamination of hydrogen atom of the amine group
Pharmacology and Phytochemistry of Oleo-Gum Resin of Commiphora wightii (Guggulu)
Guggulu is an oleo-gum resin which exudes out as a result of injury from the bark of Commiphora wightii (Arnott) Bhandari [syn. Commiphora mukul (Hook. Ex Stocks) Engl; Balsamodendron mukul (Hook. Ex Stocks); Family, Burseraceae]. It has been used in the Ayurveda since time immemorial for the treatment of variety of disorders such as inflammation, gout, rheumatism, obesity, and disorders of lipids metabolism. It is a mixture of phytoconstituents like volatile oil which contains terpenoidal constituents such as monoterpenoids, sesquiterpenoids, diterpenoids, and triterpenoids; steroids; flavonoids; guggultetrols; lignans; sugars; and amino acids. This review is an effort to compile all the information available on all of its chemical constituents which are responsible for its therapeutic potential. The wild occurrence of this species is restricted mainly to the dry regions of Rajasthan and Gujarat States of India, and the bordering regions of Pakistan. Oleo-gum resin, guggulu, tapped from the stems of this species, is consumed in high volumes by the Indian herbal industries. There has been a decline in its wild population over the last several decades, as a result of habitat loss and degradation, coupled with unregulated harvesting and tapping of oleo-gum resin. This species is consequently assessed as Critically Endangered and enlisted in the IUCN red list of threatened species