DOES HYPERCHOLESTOLEMIA PREDISPOSE TO ROTATOR CUFF PATHOLOGIES?

Background:  Rotator cuff tear are one of most common orthopedic musculoskeletal problem gaining importance due to large health scale expenditure. Causes of rotator cuff tears are multifactorial and unclear.  Previous studies have suggested relation between elevated serum lipid profile and rotator cuff tear in western population. We therefore undertook study in our Indian population to correlate association of hypercholesterolemia with rotator cuff tear.Objective: To find association of rotator cuff pathology with hypercholesterolemia in Indian patients.Materials and methods: After obtaining clearance from institutional ethics committee. We prospectively collected fasting lipid samples of population who came to our hospitals with complaints of shoulder pain during our study period. 50 patients had rupture of rotator cuff which was confirmed by ultrasound of involved shoulder. 50 were seen for non-cuff related complaints.  We followed strict inclusion and exclusion criteria.Results: Total cholesterol, Triglycerides and low density lipoprotein concentration of patients with rotator cuff tendon tear were on higher side than control group. High density lipoprotein trend showed being lower than control group.  21 of 50 (42%) had high cholesterol (total cholesterol greater than 240mg/dl) than compared to 18 of 50 (36%) in control group. however P value=0.539 and showed no statistical significance between groups.Conclusion: In Indian population there was no correlation between hypercholesterolemia and rotator cuff tear which is statistically significant.Key words Rotator cuff tear, Hypercholesterolemia, Indian population.  Â

Near-Infrared and Optical Studies of the fast nova V4643 Sgr (Nova Sagittarii 2001)

V4643 Sagittarii or Nova Sagittarii 2001 was discovered in outburst at 7.7 mag. on 2001 February 24. Here, we present near-infrared results of this fast classical nova obtained in the early decline phase in 2001 March followed by optical observations about one month later. Subsequently we also present near-infrared spectra taken later in the nova's evolution, about four months after the outburst, when V4643 Sgr had entered the coronal phase. The spectra in the early decline phase are dominated by emission lines of the HI Brackett series and also the Paschen beta and gamma lines. We study the cause of the excitation of the the OI line at 1.128 micron and discuss the variation in its strength with time after outburst. We discuss the role of optical depth effects on the observed strengths of the hydrogen Brackett and Paschen lines and discuss possible reasons for the puzzling behavior of the Br gamma line strength and whether it is correlated with the OI 1.128 micron line behavior. An optical spectrum is presented which shows that HeII lines are the most prominent features - after HI - to be seen in early 2001 April. We present and also discuss spectra taken in 2001 June and August which prominently show coronal lines of [Si VI] and [Si VII] at 1.9641 micron and 2.4807 micron respectively.Comment: Accepted in MNRA

Optical studies of novae

We review the observational characteristics of classical and recurrent novae in the optical region, in the context of observational programmes carried out using telescopes at the Vainu Bappu Observatory (VBO) and the Indian Astronomical Observatory (IAO) of the Indian Institute of Astrophysics. The article discusses the different classes of novae, based on either their outburst light curve properties, or their spectral development. Also provided is a brief discussion on the quiescence properties of novae

TCP J18224935-2408280: a symbiotic star identified during outburst

TCP J18224935-2408280 was reported to be in outburst on 2021 May 19. Follow-up spectroscopic observations confirmed that the system was a symbiotic star. We present optical spectra obtained from the Himalayan Chandra Telescope during 2021-22. The early spectra were dominated by Balmer lines, He I lines and high ionization lines such as He II. In the later observations, Raman scattered O VI was also identified. Outburst in the system started as a disc instability, and later the signature of enhanced shell burning and expansion of photospheric radius of the white dwarf was identified. Hence we suggest this outburst is of combination nova type. The post-outburst temperature of the hot component remains above 1.5 x 10$^5$ K indicating a stable shell burning in the system for a prolonged time after the outburst. Based on our analysis of archival multiband photometric data, we find that the system contains a cool giant of M1-2 III spectral type with a temperature of $\sim$ 3600K and a radius of $\sim$ 69 R$_\odot$. The pre- and post-outburst light curve shows a periodicity of 631.25 $\pm$ 2.93 d; we consider this as the orbital period.Comment: 10 pages, 12 figures, 3 table; published in MNRA

AN IN VITRO STUDY OF CINNAMOMUM ZEYLANICUM AS NATURAL INHIBITOR OF ANGIOTENSIN-CONVERTING ENZYME (ACE) ON SHEEP (OVIS ARIES) TISSUES

Objective: The present study was aimed to find the angiotensin-converting enzyme (ACE) inhibitory activity using the methanolic extract ofCinnamomum zeylanicum (as a natural inhibitor) on sheep tissues as the enzyme source.Methods: Hippuryl-histidyl-leucine (HHL) as a substrate, tissue ACE activity was measured spectrophotometrically at 228 nm. For an incubationperiod of 30 minutes at 37°C, the linearity of ACE activity of kidney, lung, and testis enzyme was established. A known medicinal plant C. zeylanicumwas used as natural inhibitor of ACE. In this enzyme assay, inhibitory effect of methanolic extract of C. zeylanicum on kidney, lung and testicular ACEwas determined. ACE activity was confirmed by captopril, a standard inhibitor of ACE.Results: In the presence of a methanolic extract of C. zeylanicum (10:1), ACE activity was determined and this has inhibited ACE activity verysignificantly. C. zeylanicum leaves extract has reduced sheep kidney, lung, and testis ACE activity by 70.06%, 12.63%, and 20.23%, respectively.Conclusion: Significant inhibition was observed in the kidney ACE than in lung and testis ACE activity. This can propose that there may be a possiblerole in controlling blood pressure or reduction in cardiovascular diseases. Some plants with the great medicinal property may be considered aspromising sources of natural inhibitors of ACE for medicine and commercial uses. This comprehensive study may show numerous beneficial effects asa potential therapeutic agent for lowering blood pressure.Keywords: Angiotensin-converting enzyme, Natural angiotensin-converting enzyme inhibitor, Kinetic assay, Hippuryl-histidyl-leucine, Cinnamomumzeylanicum, Cardiovascular diseases

Nova V4444 Sagittarii 1999 in the early decline and quiescent phases

We present near-infrared and optical spectra of the fast nova V4444 Sagittarii at two single epochs in the early decline phase and unfiltered images obtained in quiescence. Based on this and other available data, we discuss about the nature of this nova, including the possibility of it being a recurrent nova

Immune Checkpoint Inhibitors for the Treatment of Central Nervous System (CNS) Metastatic Disease

While the CNS has long been viewed as an immune-privileged environment, a paradigm shift in neuro-immunology has elevated the role of systemic immunotherapy for the treatment of metastatic disease. Increasing knowledge regarding the presence of a CNS lymphatic system and the physical and biochemical alteration of the blood brain barrier (BBB) by the tumor microenvironment suggests immune cell trafficking in and out of the CNS is possible. Emerging clinical data suggest immune checkpoint inhibitors (ICIs) can stimulate T cells peripherally to in turn have anti-tumor effects in the CNS. For example, anti-programmed cell death-1 (PD-1) monotherapy with pembrolizumab has shown intracranial response rates of 20–30% in patients with melanoma or non-small cell lung cancer (NSCLC) brain metastases. The combination of nivolumab and ipilimumab [anti-PD-1 and anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)] showed an intracranial response rate of 55% in patients with melanoma brain metastases. More data are needed to confirm these response rates and to determine mechanisms of efficacy and resistance. While local therapies such as stereotactic radiosurgery (SRS), whole-brain radiation therapy (WBRT), and surgery remain current mainstays, ICIS offer potential decreased neurotoxicity. This review summarizes the biological rationale for systemic immunotherapy to treat CNS metastatic disease, existing clinical data on ICIs in this setting and ongoing clinical trials exploring areas of unmet need