Sinusitis and the related remedies in Persian medicine

Sinusitis is a very common inflammatory disorder that is associated with high healthcare spending and impairs life quality. Thus, in this review study, we aimed at discussing the standpoints on its diagnosis, pathophysiology, medication, and perspective management according to Persian Medicine (PM). To this goal, the studies on sinusitis were collected from the selected medical and pharmaceutical textbooks of PM to be then analyzed. A search on databases as Google Scholar, Science Direct, PubMed, Web of Science and Scopus was also performed to reconfirm the Anti-inflammatory and Antimicrobial activity of reported herbs. In PM, the term Nazleh and Zokam (NaZ) was used to describe what is now named as sinusitis. It was reported that NaZ contained the substances secreted from paranasal sinuses (Botoun-e-Demaghy). Etiologically, NaZ is classified into warm and cold types. Comparing the symptoms, warm NaZ resembles Allergic rhinitis or acute episode of common cold and cold NaZ is similar to acute/chronic episode of rhinosinusitis. Based on the PM management of this disorder, modification of life style was recommended besides observing the basic treatment rules by using pharmacotherapy and following some simple manipulations. In this review, we tried to explain the medieval scientists’ intervention methods for sinusitis based on their knowledge. © 2018, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved

Effect of oregano oil (Origanum vulgare l.) on chronic rhinosinusitis: A randomized, double-blind, clinical trial

According to new investigations, oregano oil nasal spray can be used to treat patients with chronic rhinosinusitis (CRS) effectively. The current study examines the incremental effect of oregano oil and the use of Persian medicine lifestyle modification (PML). 75 adult patients with CRS participated in this study; the clinical trial was done in Otolaryngology Clinic of the Fifth Azar Hospital from January 30 to June 25, 2018. A kit including saline bottle, identical PML instruction, and identical nasal sprays containing either oregano oil (intervention group), fluticasone (control group) or sesame oil (placebo group) was given to all participants for 4 weeks. The reduction of mean change in SNOT-22 scores were 51.52 (95 CI,-55.79 to-47.24), 21.60 (95 CI,-25.48 to-17.71) and 11.84 (95 CI,-13.18 to-10.51) points for those in the oregano, fluticasone and placebo group, respectively. The mean difference of oregano to fluticasone and oregano to placebo group were 29.92 (-35.78 to-24.05) to 39.68 (-45.54 to-33.81) point, respectively, in favor of the oregano group. This study shows that oregano oil results in clinically meaningful benefits beyond those of fluticasone and sesame oil for patients with CRS without nasal polyps. Nonetheless, its generalization should be explored further. © 2020, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved