Antioxidant potential of different extracts and fractions of Catharanthus roseus shoots

Antioxidant effectiveness of indigenous medicinal plant C. roseus shoots extracts and fractions with solvents of different polarity (n–hexane, ethylacetate, methanol, chloroform) was assessed for total phenolics content (TPC), total flavonoid contents (TFC), DPPH radical scavenging activity and % inhibition of peroxidation in linoleic acid system. The C. roseus extracts and fractions contained appreciable levels of total phenolic contents 3.2 to 8.5 GAE (g/100g per dry matter) and total flavonoid contents 1.8 to 5.4 CE (g/100 of per dry matter). The C. roseus shoots extracts and fractions also exhibited good DPPH radical IC50, 28.2 to 119 µg/ml and Inhibition of Peroxidation in Linoleic Acid (38.4 to75.1%) respectively. Of the C. roseus shoots extracts and fractions tested, 100% methanolic extract exhibited the maximum antioxidant activity, the results of the present investigation demonstrated significant (p<0.05) variations in the antioxidant activity. The results of the present comprehensive analysis demonstrated that C. roseus extracts and fractions are a viable source of natural antioxidants and might be exploited for functional foods and nutraceutical applications

Acceptance rate, hesitancy and comorbidities in pregnant women: A COVID-19 vaccination status

We analyzed the electronic data (e-data) of n=5231 vaccinated candidates including n=3671 males and n=1560 females. We studied the COVID-19 vaccine brands such as Sino pharm, CanSino, SinoVac, Moderna and Pfizer. We noted adverse effects in post-vaccinated candidates were Instability in blood pressure 29.5%, Swelling 3.5%, Redness 14.2%, Itching 7.13%, and Rashes 2.4%. Comorbidities in the vaccinated candidates such as Hypertension 33%, Diabetes mellitus 17%, Kidney disease 42%, and Chronic respiratory disease 9%. COVID-19 vaccine hesitancy 1153, 22% and Non-Hesitant 4078, 77%. We analyzed the e-data of COVID-19 vaccinated candidates, the acknowledgement of COVID-19 immunization in pregnant women. Worrying about vaccine safety was the significant justification for hesitancy. Recognizing mentalities among study groups will be valuable for coming up with vaccine strategies that increment the ongoing pandemic