1 research outputs found
Reference intervals for hematology test parameters from apparently healthy individuals in southwest Ethiopia
Background: Clinical laboratory reference intervals are an important tool to identify abnormal laboratory test results. The generating of hematological parameters reference intervals for local population is very crucial to improve quality of health care, which otherwise may lead to unnecessary expenditure or denying care for the needy. There are no well-established reference intervals for hematological parameters in southwest Ethiopia. Objective: To generate hematological parameters reference intervals for apparently healthy individuals in southwest Ethiopia. Methods: A community-based cross-sectional study was conducted involving 883 individuals from March to May 2017. Four milliliter of blood sample was collected and transported to Jimma University Medical Center Laboratory for hematological analysis and screening tests. A hematological parameters were measured by Sysmex XS-500i hematology analyzer (Sysmex Corporation Kobe, Japan). The data were analyzed by SPSS version 20 statistical software. The non-parametric independent KruskalβWallis test and Wilcoxon rank-sum test (MannβWhitney U test) were used to compare the parameters between age groups and genders. The 97.5 percentile and 2.5 percentile were the upper and lower reference limit for the population. Results: The reference interval of red blood cell, white blood cell, and platelet count in children were 4.99βΓβ10 12 /L (4.26β5.99βΓβ10 12 /L), 7.04βΓβ10 9 /L (4.00β11.67βΓβ10 9 /L), and 324.00βΓβ10 9 /L (188.00β463.50βΓβ10 9 /L), respectively. The reference interval of red blood cell, white blood cell, and platelet count in adults was 5.19βΓβ10 12 /L (4.08β6.33βΓβ10 12 /L), 6.35βΓβ10 9 /L (3.28β11.22βΓβ10 9 /L), and 282.00βΓβ10 9 /L (172.50β415.25βΓβ10 9 /L), respectively. The reference interval of red blood cell, white blood cell, and platelet count in geriatrics were 5.02βΓβ10 12 /L (4.21β5.87βΓβ10 12 /L), 6.21βΓβ10 9 /L (3.33β10.03βΓβ10 9 /L), and 265.50βΓβ10 9 /L (165.53β418.80βΓβ10 9 /L), respectively. Most of the hematological parameters showed significant differences across all age groups. Conclusion: Most of the hematological parameters in this study showed differences from similar studies done in the country. This study provided population-specific hematological reference interval for southwest Ethiopians. Reference intervals should also be established in the other regions of the country