Diverse Presentation of Neurotoxicity After CAR-T Therapy in Multiple Myeloma Patients

https://openworks.mdanderson.org/aprn-week-23/1020/thumbnail.jp

Clinical Characteristics And Response Outcomes in Older Multiple Myeloma Patients Who Received Idecabtagene Vicleucel : A Single Center Study​

Nilesh Kalariya pictured.https://openworks.mdanderson.org/aprn-week-22/1014/thumbnail.jp

Human lens epithelial layer in cortical cataract

Normal and cataractous human eye lenses were studied by morphology and protein analysis. A marked decrease in protein sulfhydryl (PSH) and nonprotein sulfhydryl (NSPH) was observed in nuclear and cortical cataractous epithelia. Moreover, decrease in PSH contents and an increase in insoluble proteins were found to be correlated only in cortical cataractous epithelium which is also accompanied by various morphological abnormalities. In nuclear cataractous epithelium, however, there was very little insolubilisation of proteins. The epithelial morphology in nuclear cataracts was almost similar to normal lens epithelium. Hence, it is assumed that the protein insolubilisation and various morphological abnormalities are characteristics of cortical cataractous epithelium. This leads us to believe that opacification in cortical cataract might initiate in the epithelial layer

Secondary monoclonal gammopathy of unknown significance with isotype switching after CAR T-cell therapy for multiple myeloma: A case report

The incidence of secondary monoclonal gammopathy of undetermined significance is limited in patients with multiple myeloma post chimeric antigen receptor T-cell therapy. This is a case of secondary monoclonal gammopathy of undetermined significance with the appearance of distinct paraprotein peaks demonstrating isotype switching from IgA lambda to IgG lambda within 6 months post autologous chimeric antigen receptor T-cell therapy in a 66 year old multiple myeloma patient. Secondary monoclonal gammopathy of undetermined significance with or without isotype switching and/or new paraprotein bands may be a rare but important example of a benign and transient phenomenon representing pseudo-disease progression and potentially associated with longer progression-free survival and better overall outcomes. Although such association remains speculative given paucity of literature and an absence of high-quality data

Preventive Effects of Ethyl Pyruvate on Endotoxin-Induced Uveitis in Rats

Our studies indicate that ethyl pyruvate prevents lipopolysaccharide-induced nuclear factor kappa B–dependent ocular inflammatory signals in cultured cells and in rat eyes. Therefore, supplementation of ethyl pyruvate could be a novel approach to control ocular inflammation, especially uveitis

Prevention of Endotoxin-Induced Uveitis in Rats by Plant Sterol Guggulsterone

The authors suggest that the plant sterol guggulsterone suppresses bacterial endotoxin-induced inflammatory signaling through the PI3K/AKT/NF-κB pathway, leading to uveitis, and that it could therefore be used as a novel therapeutic agent for the treatment of ocular inflammation, especially uveitis