Intramedullary spinal cord metastasis from mammary carcinoma

Metastases to the substance of the spinal cord are almost certainly more frequent than generally supposed. The majority of previously reported cases have been bronchogenic primaries and only three have been from mammary carcinomas. The case of a 47-year-old woman who became paraplegic eight years after radical mastectomy for carcinoma of the breast is reported. An episode of herpes zoster in the fourth thoracic dermatome preceded the onset of paraplegia. At necropsy there were widespread metastases in many organs. A solitary metastasis was found in the thoracic cord extending from T3 to T6 and extending into a dorsal nerve root at T4

Type and incidence of lesions found in a human necropsy survey of skeletal muscle

No abstract availabl

Rheumatoid arthritis, polyarteritis, polymyositis, gastritis and Hashimoto's thyroiditis

No abstract availabl

Regeneration in duchenne muscular dystrophy: A histological and histochemical study

It is now well known that regeneration occurs in skeletal muscle and the sequence of events has been studied extensively in the experimental animal both with the light..

The natural history of human muscle diseases studied by means of serial biopsy

No abstract availabl

A histological and histochemical study of skeletal muscle regeneration in polymyositis

The histological features of regenerating muscle fibres in biopsies from cases of polymyositis have been examined, and the activities of certain enzymes in these fibres have been assessed histochemically. Regenerative changes were most prominent in segments of muscle fibres which had undergone necrosis. Mononucleated myoblasts appeared at the periphery of necrotic fibres before completion of phagocytosis and divided by mitosis. Multinucleated syncitia were found in a similar position and extended along empty sarcolemmal tubes. No evidence of nuclear division was found in these structures, suggesting that they were formed by myoblast fusion. Budding from the remaining ends of necrotic fibres was a less frequent finding. However, changes suggestive of increased ribonucleoprotein formation in the terminal ends of these fibres were commonly found and were considered to be indicative either of regenerative activity or of lysosomal enzyme synthesis. Degenerative changes such as vacuolation and nuclear pyknosis were found in some regenerating fibres. A second biopsy from the same muscle after clinical recovery in one case showed completely normal muscle architecture indicating that complete regeneration had occurred. Regenerating fibres were found to have a high content of RNA and high LDH, SDH and NADH-dehydrogenase activities. However, only small amounts of neutral fat were present and phosphorylase activity was completely absent in regenerating fibres. The present findings demonstrate the ability of the damaged muscle fibre to regenerate completely in polymyositis and contrast with the ineffective regenerative changes found in the Duchenne form of muscular dystrophy. These differences account for the contrasting natural histories of these two myopathies

Restricted forms of muscular dystrophy: A study of 11 cases

No abstract availabl

Globoid aneurysms of the cerebral vessels

No abstract availabl