18 research outputs found
Interleukin-6 (IL-6) is secreted from the brain after intracerebroventricular injection of IL-1 beta in rats
No full textEffect of Fasting on the Content of Thyrotropin-releasing Hormone and its mRNA in the Central Nervous System and Pyroglutamyl Peptidase II Activity in the Anterior Pituitary of Post-Weaned and Adult Rats
No full textDecreased thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus of patients with major depression
No full textCaloric Intake Stimulates Growth Hormone Secretion in Food-Deprived Rats with Anterolateral Deafferentation of the Medial Basal Hypothalamus or Administered Antiserum to Somatostatin
No full textDeletion of the ventral noradrenergic bundle obliterates the early ACTH response after systemic LPS, independently from the plasma IL-1β surge
No full textImmunocytochemical and autoradiographic studies of the endocrine cells interacting with GABA in the rat stomach
No full textThere are now increasing evidences suggesting that GABA is able of direct interaction with certain endocrine cells. In the present study, highly specific anti-GABA-glutaraldehyde antibodies and 3H-GABA uptake were used at the light and electron microscope levels to investigate the occurrence of cells containing endogenous GABA or taking up exogenous GABA in the mucosal antrum and corpus of the rat stomach. Only certain endocrine cell types of both regions were immunostained or grain-labelled. However, the morphology of their secretory granules did not allow to identify the nature of their hormone with certainty but suggested that somatostatin-like cells could interact with GABA. The combination of gastrin and somatostatin immunodetection with 3H-GABA uptake autoradiography at the light microscope level, revealed that a subpopulation of somatostatin-like cells and other still unidentified endocrine cells are able to take up GABA, while the gastrin-like cells are not. These results reinforce the hypothesis that certain endocrine cell types of the diffuse endocrine system of the digestive tract are able to directly interact with GABA
Effect of Fetal Ethanol Exposure on the In Vitro Release of Growth Hormone, Somatostatin and Growth Hormone-Releasing Factor Induced by Clonidine and Growth Hormone Feedback in Male and Female Rats
No full textThe neuroimmune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamics
No full textAssessment of hair cortisol in euthyroid, hypothyroid, and subclinical hypothyroid subjects
No full textClass A GPCR: Di/Oligomerization of Glycoprotein Hormone Receptors
No full textG protein-coupled receptor (GPCR) dimerization and oligomerization was first described over 2 decades ago, contributing to the recent paradigm shift in GPCR signaling of a simplistic, archetypal view involving single receptors activating specific heterotrimeric G proteins at the cell surface, to one of an increasing complex receptor signaling system. However, our understanding of how dimerization and oligomerization, particularly homomerization, generates functional diversity in GPCR signaling is poorly understood. For the Class A/rhodopsin subfamily of glycoprotein hormone receptors (GpHRs), di/oligomerization has been demonstrated to play a significant role in regulating its signal activity at a cellular and physiological level and even pathophysiologically. Here we will describe and discuss the developments in our understanding of GPCR oligomerization, primarily the role of homomeric receptor complexes, in both health and disease, from the study of this unique and complex subfamily of GPCRs
