Base-induced generation of aryl(1,2,3-triazol-1-yl)carbenes from 1-[(N-phenylsulfonyl)benzohydrazonoyl]-1,2,3-triazoles and their ring enlargement to 3-aryl-1,2,4-triazines

The Bamford-Stevens reactions of 1-[N-(phenylsulfonyl)benzohydrazonoyl]-1,2,3-triazole derivatives, readily available from the 1,3-dipolar cycloadditions of N-(phenylsulfonyl)benzohydrazonoyl azides with enamines, were examined and the transformation from aryl(1,2,3-triazol-1 -yl)carbene intermediates to the corresponding 3-aryl-1,2,4-triazine derivatives was first observed.ArticleHETEROCYCLES. 65(2): 279-286 (2005).journal articl

First ring contraction-desulfurization of 1-(arylcarbonyl)pyrido[2,1-c]-1,4-thiazines to 1-(arylcarbonyl)indolizines and its application to 3-arylthieno[3,2-a]indolizine synthesis

The ring contraction-desulfurization route from transient 1-(arylcarbonyl)pyridol2,1-c]-1,4-thiazine intermediates, generated in situ from the treatment of the corresponding pyridinium salts with a base and then a dehydrogenation agent, to 1-(arylcarbonyl)indolizines was first observed. By using this route three 1-arylcarbonyl-6,8-dimethylindolizines having the protected 2-thiol group were prepared and their transformation to 2-acyl-3-arylthieno[3,2-a]indolizine derivatives were performed in good yields.ArticleHETEROCYCLES. 74: 521-532 (2007)journal articl

Different photochemical behavior of bis(biphenyl)ethylenes and ethenes in solution and in the solid-state: Structurally controlled Z/E-photoisomerization in the solid-state

ArticleJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY. 184(1-2): 44-49 (2006)journal articl

Expert consensus document: Semantics in active surveillance for men with localized prostate cancer — results of a modified Delphi consensus procedure

Active surveillance (AS) is broadly described as a management option for men with low-risk prostate cancer, but semantic heterogeneity exists in both the literature and in guidelines. To address this issue, a panel of leading prostate cancer specialists in the field of AS participated in a consensus-forming project using a modified Delphi method to reach international consensus on definitions of terms related to this management option. An iterative three-round sequence of online questionnaires designed to address 61 individual items was completed by each panel member. Consensus was considered to be reached if ≥70% of the experts agreed on a definition. To facilitate a common understanding among all experts involved and resolve potential ambiguities, a face-to-face consensus meeting was held between Delphi survey rounds two and three. Convenience sampling was used to construct the panel of experts. In total, 12 experts from Australia, France, Finland, Italy, the Netherlands, Japan, the UK, Canada and the USA participated. By the end of the Delphi process, formal consensus was achieved for 100% (n = 61) of the terms and a glossary was then developed. Agreement between international experts has been reached on relevant terms and subsequent definitions regarding AS for patients with localized prostate cancer. This standard terminology could support multidisciplinary communication, reduce the extent of variations in clinical practice and optimize clinical decision making