A Smooth Lattice construction of the Oppenheimer-Snyder spacetime

We present test results for the smooth lattice method using an Oppenheimer-Snyder spacetime. The results are in excellent agreement with theory and numerical results from other authors.Comment: 60 pages, 28 figure

MLPA is a powerful tool for detecting lymphoblastic transformation in chronic myeloid leukemia and revealing the clonal origin of relapse in pediatric acute lymphoblastic leukemia

Microscopic imaging and technolog

Sequential and Hierarchical Chromosomal Changes and Chromosome Instability are Distinct Features of High Hyperdiploid Pediatric Acute Lymphoblastic Leukemia

Microscopic imaging and technolog

Solid and papillary epithelial neoplasm arising in heterotopic pancreatic tissue of the mesocolon

Aim—Solid and papillary epithelial neoplasm (SPEN) is an uncommon pancreatic tumour. Very rarely it has also been described outside the pancreas, usually arising from heterotopic pancreatic tissue. This report summarises all the published extrapancreatic SPENs and documents the sixth such case arising from heterotopic pancreatic tissue of the transverse mesocolon in a 15 year old girl. Methods/Results—Histological and immunohistochemical examination revealed typical papillary and solid areas composed of columnar, cuboidal, and round cells, which were focally positive for vimentin, cytokeratin, neurone specific enolase, carcinoembryonic antigen, α1-antitrypsin, α1-antichymotrypsin, and negative for neuroendocrine markers (neurofilament, PGP 9.5, chromogranin A, synaptophysin, and S100), p53, and oestrogen and progesterone receptors. Electron microscopy showed scant zymogen but no neurosecretory granules. In agreement with the flow cytometric result of diploidy, comparative genomic hybridisation (CGH) did not reveal loss or gain of genetic material, and the in situ hybridisation analysis of the RB1 and p53 genes revealed no abnormality in the 13q and 17p arms. Conclusions—Immunohistochemical and electron microscopic data support exocrine differentiation. The CGH and the flow cytometric results suggest a subtle, yet unknown genetic change, rather than a large genetic alteration. RB1 and p53 in situ hybridisation ruled out the role of deletion at these sites in the pathogenesis of SPEN. Interestingly, review of the published and the present heterotopic pancreatic SPENs identified the mesocolon as the most common anatomical site (four of six), despite the very rare occurrence of ectopic pancreatic tissue at this site. Key Words: solid papillary epithelial neoplasm • heterotopic/ectopic pancreas • mesocolo

Multiplex ligation-dependent probe amplification and fluorescence in situ hybridization are complementary techniques to detect cytogenetic abnormalities in multiple myeloma

Cancer Signaling networks and Molecular Therapeutic